Co-administration of caffeine and hydromethanolic fraction of Citrullus lanatus seeds improved testicular functions in alloxan-induced diabetic male Wistar rats

Onyeso, Godspower I.; Nkpaa, Kpobari W.; Omenihu, S.

doi:10.1016/j.apjr.2016.01.004

Cited by 8 publications

(5 citation statements)

References 11 publications

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“…These results were supported by the histopathological findings of the liver as it showed a better improvement of the hepatic tissue (Plate 2). The dose-dependent reduction in AST, ALT, ALP activities observed in groups treated with aqueous seeds extract of C. vulgaris in this study is in line with the report of [31] who reported similar decrease following the administration of 200 mg/kg bwt C. lanatus seeds.…”

Section: Discussionsupporting

confidence: 92%

Assessment of Ameliorative Role of Citrullus vulgaris (Schrad) Seeds on Caffeine-induced Hepatic and Renal Dysfunction in Male Wistar Rats

Feyisayo,

Toyin,

Blessing

et al. 2024

EJMP

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Caffeine is the most widely consumed psychoactive drug in the world. It is often marketed for its physical and cognitive performance benefits. Unlike many other psychoactive substances, it is legal and unregulated in nearly all parts of the world. The ingestion of potentially toxic amounts of caffeine in the forms of energy drinks, over-the-counter supplements, addiction or use of anhydrous caffeine products places individuals at risk for accidental overdose. An overdose of this drug is not without its attendant consequences on the liver and the Kidney. This study therefore aimed at evaluating the possible hepatoprotective and nephroprotective effects of Citrullus vulgaris seed extracts on caffeine induced toxicity. Thirty (30) male Wistar rats were divided into five groups. They were induced with caffeine (100 mg/kg) and treated with graded doses (100, 300 and 500 mg/ kg bwt.) of aqueous seeds extract of C. vulgaris for 21 days. The plasma activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) were determined and the concentrations of total protein, albumin, total bilirubin, creatinine and urea were estimated. Electrolytes (sodium, calcium, potassium and magnesium ion) were also estimated. Plasma lipid profiling (total cholesterol, triacylglyceride, high density lipoprotein (HDL), Low density lipoprotein (LDL) was carried out and the liver and kidney of the rats were examined for histopathological changes. The results showed that administration of aqueous seeds extract of Citrullus vulgaris restored the levels of the plasma enzymes, blood proteins, urea and creatinine as well as the levels of electrolytes close to normal control levels which were significantly altered by caffeine intoxication, Photomicrographs sections of the liver and kidney showed that the aqueous seeds extract of Citrullus vulgaris was able to repair damage to organs caused by caffeine-intoxication. The study concluded that the aqueous seeds extract of C. vulgaris possesses ameliorative potential against hepatic and renal damage that arises from caffeine-intoxication.

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Section: Discussionsupporting

confidence: 92%

Assessment of Ameliorative Role of Citrullus vulgaris (Schrad) Seeds on Caffeine-induced Hepatic and Renal Dysfunction in Male Wistar Rats

Feyisayo,

Toyin,

Blessing

et al. 2024

EJMP

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“…in a saline solution. [17] 10% dextrose was there after administered orally to combat the immediate hypoglycemia that could occur. [18] Then on 4 th day fasting blood sugar level was checked in each animal by using glucose kit and animals with fasting blood sugar above 200 mg/dl were included in study.…”

Section: Induction Of Experimental Diabetesmentioning

confidence: 99%

Antidiabetic Activity of Extracts of Pithecellobium Dulce Benth Leaves in Alloxan Induced Diabetic Rats

Mul¹,

Naikwade²,

Magdum³

et al. 2016

Int. J. Pharm. Sci. Drug Res.

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The objective of the present study was to study effect of Pithecellobium dulce Benth (P. dulce) leaves in alloxan induced diabetic rats. The P. dulce leaves were extracted by maceration and soxhelation method by using water and ethanol as solvent. Acute toxicity study was performed according to OECD 425 guidelines for both aqueous and ethanolic extracts of P. dulce leaves. The dose of 200 mg/kg and 400 mg/kg was selected for further studies. Animals were rendered diabetic by administration of alloxan (130 mg/kg, i.p.). The albino rats were divided in to seven groups with five animals in each group. Diabetic animals were treated with aqueous and ethanolic extract for 20 days. Then blood glucose, triglyceride, total cholesterol, urea, uric acid, creatinine, aspartate aminotransferase (AST), alanine transaminase (ALT) and glycogen level in liver, muscle and kidney were estimated according to standard procedures. The result shows significant decrease in blood glucose, triglyceride, total cholesterol, urea, uric acid, creatinine, AST and ALT level when compared to diabetic group. The liver and muscle glycogen level was increased significantly in extract treated groups when compared to diabetic control group. Both extract of P. dulce posses antidiabetic and hypolipidemic potential.

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“…To investigate the anti‐hypercholesterolemic potential of sweet melon ( Cucumis melo ) seed oils (SEO and CPO), the blood lipid profile of animals was analyzed for total cholesterol (TC), HDL, LDL and TG levels by using commercially available diagnostic kits as followed by Onyeso et al 14 …”

Section: Methodsmentioning

confidence: 99%

Cucumis melo seed oil: agro‐food by‐product with natural anti‐hyperlipidemic potential

et al. 2022

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BACKGROUND Sweet melon (Cucumis melo) seed is generally considered as agro‐waste, however, the current study aimed to use this waste as a valuable oil source. The seed oil extracted by two different extraction techniques (cold press and solvent extraction) was investigated for its anti‐hyperlipidemic potential. Hyperlipidemic rabbits were fed on the diet supplemented with sweet melon seed oil for 6 weeks (42 days) and thoroughly examined for the change in their lipid profile. RESULTS The blood lipid profile indicated a significant decrease in total cholesterol triglyceride and low‐density lipoprotein (LDL) contents of blood in hyperlipidemic rabbits fed on the diet supplemented with sweet melon seed oils while high‐density lipoprotein (HDL) contents showed a noteworthy increase during the study period. CONCLUSION Cucumis melo seed oil can be used to control hyperlipidemia without restricting the intake of lipids in diet. Solvent extraction provided better results regarding extraction yield and product functionality than cold press method. © 2022 Society of Chemical Industry.

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Co-administration of caffeine and hydromethanolic fraction of Citrullus lanatus seeds improved testicular functions in alloxan-induced diabetic male Wistar rats

Cited by 8 publications

References 11 publications

Assessment of Ameliorative Role of Citrullus vulgaris (Schrad) Seeds on Caffeine-induced Hepatic and Renal Dysfunction in Male Wistar Rats

Assessment of Ameliorative Role of Citrullus vulgaris (Schrad) Seeds on Caffeine-induced Hepatic and Renal Dysfunction in Male Wistar Rats

Antidiabetic Activity of Extracts of Pithecellobium Dulce Benth Leaves in Alloxan Induced Diabetic Rats

Cucumis melo seed oil: agro‐food by‐product with natural anti‐hyperlipidemic potential

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