Co-administration of metformin and/or glibenclamide with losartan reverse N-nitro-l-arginine-methyl ester-streptozotocin-induced hypertensive diabetes and haemodynamic sequelae in rats

Moke, Emuesiri Goodies; Omogbai, Eric K. I.; Osagie-Eweka, Sammy D.E.; Uchendu, Adaeze P; Omogbiya, A.I.; Ben-Azu, Benneth; Eduviere, Anthony T.; Edje, K.E.; Umukoro, Emuesiri Kohworho; Anachuna, Kenneth Kelechi; Asiwe, Jerome Ndudi; Ahante, Ejiroghene; Oghoghovwe, Ighohwo J.

doi:10.1016/j.mvr.2023.104497

Cited by 4 publications

(8 citation statements)

References 51 publications

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“…As regards the estimation of biomarkers cardiac injury, serum levels of LDH and CK were used as previous described [50]. Accordingly, we also found that DOCA/ STZ-induced comorbid hypertensive diabetic states were accompanied by significantly elevated serum levels of LDH and CK, which possibly suggest evidence of cardiac tissue damage [45,50]. However, LOS + MET, LOS + GLB and LOS + MET + GLB produced a significant reduction in LDH level.…”

Section: Discussionmentioning

confidence: 86%

“…Notably, Alotaibi and colleagues reported the therapeutic effectiveness of combining GLB with LOS in diabetic states [44]. The efficacy of the combination of antidiabetic agents have also been reported [45][46][47][48]. A separate study revealed the hypoglycemic activity of a combination of glimepiride (a sulfonyurea) and MET was enhanced when LOS was co-administered as a single dosage schedule as well as a multiple dose schedule [49].…”

Section: Discussionmentioning

confidence: 99%

“…In this study, we observed that weekly administration of these drugs led to a dramatic reduction in SBP and HR, although there were no significance changes in DBP and MAP. Of note, it is an indication that the drug combinations can be used for effective management of blood pressure in hypertensive diabetic states, particularly by reducing systolic pressure [45].…”

Section: Discussionmentioning

confidence: 99%

“…The BP monitoring sensor was placed round the tail root of rats. Following animal movement stability, the data of SBP, DBP, MAP and HR were recorded [45].…”

Section: Measurement Of Blood Pressurementioning

confidence: 99%

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Antihypertensive and antihyperglycemic effects of combinations of losartan with metformin and/or glibenclamide in desoxycorticosterone acetate and streptozotocin-induced hypertensive diabetic rats

et al. 2023

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Background Hypertension is a medical condition that often comorbidly exist in patients with type II diabetes. Therefore, it is very important to manage both conditions simultaneously to mitigate the complications and mortality connected with this comorbidity. Hence, this study investigated the antihypertensive and antihyperglycemic effects of combinations of losartan (LOS) with metformin (MET) and/or glibenclamide (GLB) in hypertensive diabetic rats. Hypertensive diabetic state was induced with desoxycorticosterone acetate (DOCA) and streptozotocin (STZ) in adult Wistar rats. The rats were divided into 5 groups (n = 5): control group (group 1), hypertensive diabetic (HD) control (group 2), treatment groups receiving LOS + MET (group 3), LOS + GLB (group 4), and LOS + MET + GLB (group 5). Group 1 comprised healthy rats while groups 2–5 were HD rats. The rats were treated orally once daily for 8 weeks. Fasted blood glucose (FBS) level, haemodynamic parameters, and some biochemical indices were thereafter assessed. Results FBS level and blood pressure measurements were significantly (P < 0.05) increased following induction by DOCA/STZ. The drug treatment combinations, particularly combination of LOS + MET + GLB, significantly (P < 0.05) reduced the induced hyperglycemia and remarkably decreased systolic blood pressure and heart rate. There was significant (P < 0.05) reduction in raised lactate dehydrogenase and creatinine kinase levels by all drug treatment combinations except LOS + GLB. Conclusions Our findings suggest that LOS combinations with MET and/or GLB exhibited significant antidiabetic and antihypertensive effects against DOCA/STZ-induced hypertensive diabetic state in rats.

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…The BP monitoring sensor was placed round the tail root of rats. Following animal movement stability, the data of SBP, DBP, MAP and HR were recorded [45].…”

Section: Measurement Of Blood Pressurementioning

confidence: 99%

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Antihypertensive and antihyperglycemic effects of combinations of losartan with metformin and/or glibenclamide in desoxycorticosterone acetate and streptozotocin-induced hypertensive diabetic rats

et al. 2023

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“…24 Hypoglycaemic activity Induction of diabetes in experimental animals is commonly by chemical method with streptozotocin and alloxan. [56][57][58][59][60][61][62][63][64] It usually involve the destruction of the beta-cells of the Islets of Langerhans in the pancreas with a consequent reduction in synthesis and release of insulin. 56,63 Numerous studies have reported the hypoglycemic activities of S. mombin.…”

Section: Antioxidant Activitymentioning

confidence: 99%

Phytopharmacological Activities of Spondias mombinLinn: A Review

2024

TJPPS

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This review describes the phytopharmacological activities of Spondias mombin. Spondias mombin (S. mombin) is a fructiferous tree native to tropical areas like America, Brazil, Nigeria and West India. It belongs to the cashew family of Anacardiaceae. Spondias mombin has been used as an herbal medicine from ancient times. Spondias mombin plant parts (leaves, bark, seeds, and fruits) are used for therapeutic purposes. Traditionally, the plant is being used in inducing labour, preventing miscarriages, reducing inflammation, reducing blood glucose level, amongst others. Various plant parts are also used for non-medicinal purposes like the production of cider-like drinks, wine, soap and ornamental purposes. The main bioactive compounds reported in S. mombin include tannins, phenols, saponins, anthraquinones, berberine, naphthoquinones, sesquiterpenes, indole and quinoline alkaloids, proanthocyanins, and flavonoids. Spondias mombin possesses beneficial pharmacological properties that are well-utilized in medicinal herbal therapy of several disease conditions.

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Possible homeostatic, glucose uptake mechanisms and hepato-pancreatic histological effects of intermittent fasting, exercise, starvation, and honey in streptozotocin-induced diabetes in rats

Chijiokwu

Nwangwa

Oyovwi

et al. 2023

Nutrire

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Co-administration of metformin and/or glibenclamide with losartan reverse N-nitro-l-arginine-methyl ester-streptozotocin-induced hypertensive diabetes and haemodynamic sequelae in rats

Cited by 4 publications

References 51 publications

Antihypertensive and antihyperglycemic effects of combinations of losartan with metformin and/or glibenclamide in desoxycorticosterone acetate and streptozotocin-induced hypertensive diabetic rats

Antihypertensive and antihyperglycemic effects of combinations of losartan with metformin and/or glibenclamide in desoxycorticosterone acetate and streptozotocin-induced hypertensive diabetic rats

Phytopharmacological Activities of Spondias mombinLinn: A Review

Possible homeostatic, glucose uptake mechanisms and hepato-pancreatic histological effects of intermittent fasting, exercise, starvation, and honey in streptozotocin-induced diabetes in rats

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