Co-circulations of two genotypes of dengue virus in 2006 out-break of dengue hemorrhagic fever in Karachi, Pakistan

Khan, Erum; Hasan, Rumina; Mehraj, Vikram; Nasir, Amna; Siddiqui, Jaweriah; Hewson, Roger

doi:10.1016/j.jcv.2008.06.003

Cited by 53 publications

(34 citation statements)

References 22 publications

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“…The distinctive characters of Dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) based on internal bleeding which can lead to comorbid conditions [13][14][15][16][17].…”

Section: Etiologymentioning

confidence: 99%

Dengue Fever in Pakistan, Episodes of Epidemic to Endemic: Treatment Challenges, Prevention and Current Facts

Ali¹,

Alvi²,

Fatima³

et al. 2017

J Bioequiv Availab

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“…The distinctive characters of Dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) based on internal bleeding which can lead to comorbid conditions [13][14][15][16][17].…”

Section: Etiologymentioning

confidence: 99%

Dengue Fever in Pakistan, Episodes of Epidemic to Endemic: Treatment Challenges, Prevention and Current Facts

Ali¹,

Alvi²,

Fatima³

et al. 2017

J Bioequiv Availab

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“…Dengue NS1 antigen and Dengue specific IgA antibody based assays have been shown to be useful during early febrile days. [5][6][7][8][9][10][11][12][13][14][15][16][17] ELISA and ICT based NS1 assay have been used as a diagnostic tool during febrile phase till defervescence (1 -9 days of fever onset) however, due to presence of virus -IgG immunocomplexs this assay has shown to be less sensitive in secondary infection as compared to primary infections 18,19 and may give false negative results in dengue endemic and hyperendemic areas. Studies comparing sensitives and specificities of IgA and NS1 reported dengue IgA to be more sensitive during early febrile phase of both primary and secondary dengue infection.…”

Section: -416mentioning

confidence: 99%

“…Karachi, and Lahore witnessed major out breaks. [6][7] During seasonal outbreaks large proportion of suspected dengue cases are referred to tertiary care hospitals in both public and private sectors. It has been found difficult to accommodate uncomplicated suspected dengue fever (DF) cases especially in public sector.…”

mentioning

confidence: 99%

Dengue Rapid Diagnostic Tests; Evaluation of Utility in a Tertiary Care Hospital

Kidwai

Ara

Ghaznawi

et al. 2017

TPMJ

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ABSTRACT… Objectives:To determine the point of care role of dengue IgA and Dengue IgM / IgG rapid diagnostic tests (RDTs) in a tertiary care setting in terms of day of onset of illness at presentation and frequency of positive RDTs in dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Study Design: Cross-sectional study. Setting: Abbasi Shaheed Hospital, Karachi. Period: August-2014 to January-2016. Method: Patients aged 13years and above with acute febrile illness, fulfilling the WHO case definition criteria of probable DF and DHF were included. Two immunochromatograpic (ICT) based RDTs, Assure dengue IgA and Panbio Dengue Duo Cassette (IgM / IgG) were used. Dengue IgA was employed in all patients from day 2 of illness whereas IgM / IgG was employed after day 4 of onset of fever. Result: Among 174 probable cases, 108 (62%) presented between 2 -5 days of onset of fever, among whom 87 (80.5%) were found to be dengue IgA positive. Sixty-nine (39.65%) patients had DHF, among whom 97.1% were seropositive for IgA. Of 118 patients presented after 4 days of onset of illness, 59.3% were positive by IgM / IgG rapid assay. Conclusion: Considering the higher frequency of secondary dengue and DHF in dengue endemic-hyperendemic regions, IgA based ICT might be a helpful diagnostic assay for early diagnosis of dengue infection.

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“…23 After a gap of almost 10 years, dengue outbreaks ensued again in 2005/2006 claiming many deaths, 24 with circulating serotypes of DENV-2 and the new DENV-3 (New Delhi genotype). 25,26 Since 2006, the disease extended its range from southern to northern Pakistan, resulting in outbreaks that have affected thousands of people, causing hundreds of mortalities over the course of past 7 years or so. A noteworthy observation was the presence of multiple DENV serotypes in the population during the course of these outbreaks.…”

Section: Introductionmentioning

confidence: 99%

Association of FcγRIIa Polymorphism with Clinical Outcome of Dengue Infection: First Insight from Pakistan

Mohsin

Mahmood

Amar

et al. 2015

The American Society of Tropical Medicine and Hygiene

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Abstract. Dengue illness has been a major health concern in Pakistan during the last decade. Dengue infection can result in a spectrum of clinically distinct outcomes, ranging from asymptomatic infection to potentially life-threatening forms of dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). A single-nucleotide polymorphism in FcγRIIa (rs1801274) results in altered affinity of the receptor for different subclasses of immunoglobulin G, and is a key player in determining the susceptibility to or protection from severe clinical infection of dengue. In this study, we analyzed the allelic and genotypic distribution of rs1801274 in subjects of Pakistani origin with subclinical dengue infection (n = 40), dengue fever (DF) (n = 40), and DHF/DSS (n = 30). We found that HH homozygotes and heterozygotes were significantly more likely to develop clinical dengue (odds ratio [OR] = 3.21, 95% confidence interval [CI] = 1.29-7.97, P = 0.009), either DF (OR = 2.82, 95% CI = 1.00-7.97, P = 0.045) or DHF/DSS (OR = 3.90, 95% CI = 1.13-13.07, P = 0.024) than the asymptomatic dengue infection. Results of allelic distribution comparisons and logistic regression analysis also supported the same relationship. The results suggest complex nature of interacting factors in determining the course for severe dengue illness.

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Co-circulations of two genotypes of dengue virus in 2006 out-break of dengue hemorrhagic fever in Karachi, Pakistan

Cited by 53 publications

References 22 publications

Dengue Fever in Pakistan, Episodes of Epidemic to Endemic: Treatment Challenges, Prevention and Current Facts

Dengue Fever in Pakistan, Episodes of Epidemic to Endemic: Treatment Challenges, Prevention and Current Facts

Dengue Rapid Diagnostic Tests; Evaluation of Utility in a Tertiary Care Hospital

Association of FcγRIIa Polymorphism with Clinical Outcome of Dengue Infection: First Insight from Pakistan

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