Co-delivery of Andrographolide and Notch1-targeted siRNA to Macrophages with Polymer-based Nanocarrier for Enhanced Anti-inflammation

Wang, Teng; Tong, Min; Gong, Heng-Ye; Wang, Yong; Shuai, Xintao

doi:10.1007/s10118-018-2158-z

Cited by 12 publications

(8 citation statements)

References 25 publications

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“…Inflammatory cytokines secreted by activated monocytes are critical for regulating immune responses; in order to further illustrate the therapeutic effect of SO−LGG on Pb-induced liver and kidney tissue inflammation, expression levels of inflammatory factors in liver and kidney were detected by ELISA. 25,26 Figure 5G−I shows that the concentrations of pro-inflammatory factors IL-6 and TNF-α in the livers of mice after SO−LGG treatment were decreased, while anti-inflammatory factor IL-10 was increased.…”

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confidence: 99%

“…As shown in Figure B,E, the percentage of CD11b + CD86 + cells in SO–LGG iv and SO–LGG oral groups was much lower than that in the PBS group, while this significant difference did not exist between DMSA or SO group versus PBS group. Inflammatory cytokines secreted by activated monocytes are critical for regulating immune responses; in order to further illustrate the therapeutic effect of SO–LGG on Pb-induced liver and kidney tissue inflammation, expression levels of inflammatory factors in liver and kidney were detected by ELISA. , Figure G–I shows that the concentrations of pro-inflammatory factors IL-6 and TNF-α in the livers of mice after SO–LGG treatment were decreased, while anti-inflammatory factor IL-10 was increased. In contrast, the levels of each factor in PBS, DMSA, and SO groups were similar.…”

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confidence: 99%

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Double Bacteria Synergistic Catalytic Reduction System for Heavy Metal Detoxification Treatment

Pan

Zheng

et al. 2022

Nano Lett.

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Synthetic biology has promoted the development of microbial therapy, but the scope of applicable microbial species is limited and transgenic microorganisms also display safety risks for in vivo applications. Interestingly, symbiotic microorganisms in nature can achieve functional updates by metabolic cooperation. Here, we report on a nongenetic method for engineering microorganisms to construct a heavy metal ion reduction system, which was prepared by linking Shewanella oneidensis MR-1 (SO) and Lactobacillus rhamnosus GG (LGG). SO could reduce metal ions but is limited by finite substrates in vivo. LGG could metabolize glucose to lactate as a substrate for SO, promoting extracellular electron transfer by SO and heavy metal ion reduction. Meanwhile, SO could generate electron donor cytochrome C to promote metabolism of LGG, forming metabolic synergy and circulation between these two bacteria. The SO–LGG system shows splendid ability to remove heavy metal ions and inflammatory modulation in acute or chronic heavy metal poisoning.

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confidence: 99%

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confidence: 99%

Double Bacteria Synergistic Catalytic Reduction System for Heavy Metal Detoxification Treatment

Pan

Zheng

et al. 2022

Nano Lett.

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“…Wu et al constructed a PEG-PAsp (DETA) – Lys-CA 2 polymer for co-delivery of andrographolide and targeted-Notch1 siRNA to macrophages, which can effectively alleviate atherosclerosis by reducing the inflammatory response of macrophages. 90 Andrographolide can block the NF-κB signal pathway, and targeted-Notch1 siRNA upregulates the expression level of anti-inflammatory cytokines such as interleukin (IL-10) and arginase-1, both of which act together. However, the researchers did not conduct in vivo experiments, but conducted experimental evaluation on RAW264.7 cells.…”

Section: Gene Therapy For Atherosclerosismentioning

confidence: 99%

Nanocarriers for gene delivery to the cardiovascular system

Shi,

Liu,

Zhou

et al. 2023

Biomater. Sci.

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“…The results clearly indicated that CA-based block copolymers had significant potential of delivering siRNA in the form of mixed micelles. Essentially, from all the previous literature reports, it can be speculated that CA-based ensembles act as suitable gene delivery vehicles . Keeping this in mind, one can design suitable CA-based polymeric architectures for targeted gene delivery.…”

Section: Cholic Acid-based Polymers For Therapeutic Applicationsmentioning

confidence: 99%

“…Essentially, from all the previous literature reports, it can be speculated that CA-based ensembles act as suitable gene delivery vehicles. 93 Keeping this in mind, one can design suitable CAbased polymeric architectures for targeted gene delivery.…”

Section: Cholic Acid-based Polymers For Therapeutic Applicationsmentioning

confidence: 99%

Recent Advances in Biomedical Applications of Cholic Acid-Based Macromolecules

Sahoo

Ghosh

Banerjee

et al. 2021

ACS Appl. Polym. Mater.

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In recent decades, polymeric materials have been extensively investigated for their widespread therapeutic applications in various biomedical fields. In particular, biomolecule conjugated polymers continue to draw attention due to their distinctive physicochemical and biological properties. By appending biomolecules on polymeric constructs, these synthetic macromolecules can be strategized as multimotive theranostic agents. In this Review, we intend to spotlight the biomedical applications of polymeric materials containing cholic acid (CA) as the biomolecular counterpart. CA is the most abundantly produced bile acid during cholesterol metabolism in the human body and is also the least expensive one. The fascinating properties such as inimitable facial amphiphilicity, convenient bioavailability, trivial cytotoxicity, and excellent biocompatibility make CA unique to design numerous cholic acid-based polymers (CAPs) in the diverse areas of biomedical research. The primary focus of this Review is to highlight the recent achievements (2011−present) on the obligatory role of the CA moiety in CAPs in these biomedical applications. Especially the therapeutic applications which include drug delivery, gene transfection, antimicrobial activity, bioimaging and diagnosis, wound healing, and other miscellaneous bioapplications are highlighted in this Review.

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Co-delivery of Andrographolide and Notch1-targeted siRNA to Macrophages with Polymer-based Nanocarrier for Enhanced Anti-inflammation

Cited by 12 publications

References 25 publications

Double Bacteria Synergistic Catalytic Reduction System for Heavy Metal Detoxification Treatment

Double Bacteria Synergistic Catalytic Reduction System for Heavy Metal Detoxification Treatment

Nanocarriers for gene delivery to the cardiovascular system

Recent Advances in Biomedical Applications of Cholic Acid-Based Macromolecules

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