Co-delivery of paclitaxel and gemcitabine via a self-assembling nanoparticle for targeted treatment of breast cancer

Abstract

Preparation of MF-FA nanoparticles and the release behavior of drugs in tumor cells.

Synthesis of novel, DNA binding heterocyclic dehydroabietylamine derivatives as potential antiproliferative and apoptosis-inducing agents

“…Currently, various chemotherapy drugs have been developed for the treatment of different cancers; however, undesirable side effects may greatly impede their use in clinical progression. Among a variety of cancer cures, the antiproliferative approach plays a crucial role in controlling this deadly disease (Xin et al, 2018;Lei et al, 2019b). Up to now, numerous molecules containing heterocyclic rings have showed great antiproliferative potential, particularly those with thiophene and pyrazine rings.…”

Cancer cell membrane-derived nanoparticles improve the activity of gemcitabine and paclitaxel on pancreatic cancer cells and coordinate immunoregulatory properties on professional antigen-presenting cells

“…This finding is similar to previous studies with nanoparticles conjugated with GEM plus the administration of pure PTX, exhibiting greater toxicity than the simple treatment with GEM on lung, 35 mammary, and ovary cancer cells. 36,37 The most interesting result was observed in the MNP-GEM-PTX group, indicating that paclitaxel favors MNP-GEM activity in tumor cells ( Fig. 7A and Fig.…”

A multifunctional biodegradable brush polymer-drug conjugate for paclitaxel/gemcitabine co-delivery and tumor imaging

“…This drug ratio was chosen because it is within the range of PTX/GEM mass ratios (from 1 : 1 to 1 : 25) studied in the literature on co-delivery of these two anticancer drugs. 23,31,32,[52][53][54][55][56][57] The research design of this work is different from the original PTX-GEM combination polymer conjugate produced by Kopěcek and co-workers in both the base polymer and the conjugation linkages. In their work, PHPEA was used as the base polymer of the PDC, and enzyme-sensitive Gly-Phe-Leu-Gly (GFLG) conjugation linkers were employed.…”