Co-delivery of superfine nano-silver and solubilized sulfadiazine for enhanced antibacterial functions

Luo, Ting; Shakya, Shailendra; Mittal, Priyanka; Ren, Xiuyan; Guo, Tao; Bello, Mubarak G.; Wu, Li; Li, Haiyan; Zhu, Weifeng; Regmi, Bimal Raj; Zhang, Jiwen

doi:10.1016/j.ijpharm.2020.119407

Cited by 38 publications

(29 citation statements)

References 36 publications

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“…The hydrophobic amide structure of sulfadiazine would have great affinity with the hydrophobic groups on the surface of biochar through hydrophobic partition (Ovung and Bhattacharyya 2021). In addition, as the micropores represented almost 85% of the pore volume, the hydrophobic cavities of these micropores exhibited a confinement effects for the adsorption of SDZ (Luo et al 2020) to illustrate an accelerated initial adsorption rate. The I D /I G of PABC-700 further dropped to 1.290 after use (as shown in Fig.…”

Section: Comparisons Of the Sulfadiazine Adsorption Performancementioning

confidence: 99%

Impacts of temperatures and phosphoric-acid modification to the physicochemical properties of biochar for excellent sulfadiazine adsorption

Zeng

Wang²,

et al. 2022

Biochar

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The textural properties and surface chemistry of phosphoric acid-modified biochars (PABCs) prepared at different pyrolysis temperatures (500–700 °C) were studied based on the results obtained from XRD, SEM, BET, FT-IR, Raman, XPS and elements analyses. PABCs prepared at higher temperatures tended to possess a bigger proportion of microporous structure. The adsorption capacity and initial rate of PABCs for sulfadiazine (SDZ) were notably improved to 139.2 mg/g and 9.66 mg/(g min) as calculated from the Langmuir model. The adsorption equilibrium time was only one quarter of that without modification. The H3PO4 modification was advantageous to produce phosphate and break functional groups to form disordered carbon structure abundant of micropores. The enhancement in the adsorption of SDZ was due to the confinement effect of hydrophobic cavities from the mircoporous structure and the π–π electron–donor–acceptor interaction. Specially, PABCs exhibited stable adsorption capacities at a wide pH range (3.0–9.0) or relatively high concentrations of coexisting ions.

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Section: Comparisons Of the Sulfadiazine Adsorption Performancementioning

confidence: 99%

Impacts of temperatures and phosphoric-acid modification to the physicochemical properties of biochar for excellent sulfadiazine adsorption

Zeng

Wang²,

et al. 2022

Biochar

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“…The sulfadiazine is bacteriostatic that interferes with bacteria's metabolic processes, including folic acid pathways and respiratory electron transport system. 51,77 In this context, Ag + ions lead to the primary antibacterial activity against E. coli, S. aureus, and P. aeruginosa bacterial, whereas sulfadiazine provides bacteriostatic performance. 78…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial dressing of silver sulfadiazine-loaded halloysite/cassava starch-based (bio)nanocomposites

et al. 2021

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(Bio)nanocomposites have been studied for biomedical applications, including the treatment of wounds. However, wound infection is one of the main problems of wound care management, and the use of wound dressings with antibacterial agents is essential. This work focused on developing and characterizing silver sulfadiazine-loaded halloysite/cassava starch-based (bio)nanocomposites potentially suitable as antimicrobial dressing. Silver sulfadiazine was complexed inside the halloysite nanotubes lumen, and the drug-loaded nanotubes were incorporated in thermoplastic starch dispersion, forming the (bio)nanocomposites. The silver sulfadiazine-loaded halloysite and the (bio)nanocomposite were characterized by zeta potential, scanning electron microscopy, X-ray diffraction, and infrared spectroscopy. The dressing properties of (bio)nanocomposites (water vapor permeability and mechanical stability) and their antimicrobial efficacy by Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus were also evaluated. Physicochemical studies suggested the silver sulfadiazine-loaded halloysite complexation (zeta potential of −38.9 mV) and its interactions with the starch forming the nanocomposites. The silver sulfadiazine-loaded halloysite/starch-based (bio)nanocomposites possessed a homogeneous and organized structure. Also, they had mechanical properties to be used as a dressing (13.73 ± 3.09 MPa and 3.17 ± 1.28% of elongation at break), and its permeability (6.18 ± 0.43 (10−13) g.Pa−1.s−1.m−1) could be able to maintain the environmental moisture at the wound surface. Besides that, the (bio)nanocomposites acted against the studied bacteria, being a potential contact antimicrobial and biodegradable wound dressing. Finally, the developed (bio)nanocomposites are semi-occlusive and good candidates for dry wounds to be widely in vitro and in vivo tested as controlled silver sulfadiazine delivery dressing.

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“…This allows for more effective therapy Beyond the traditional DDS carriers (liposomes, polymers…), an increasing number of possible nanocarriers have been established in recent years (mesoporous silica, zeolites, dendrimers, cages…). This includes MOFs, which have been used in preclinical studies for enhanced treatment for numerous diseases that are still challenges in modern society, such as tumor therapy, 32 antibacterial, 33,34 diabetes.…”

Section: Drug Delivery Systems (Dds)mentioning

confidence: 99%

Metal–organic frameworks towards bio-medical applications

Lepoitevin

Serre

2021

Mater. Chem. Front.

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Co-delivery of superfine nano-silver and solubilized sulfadiazine for enhanced antibacterial functions

Cited by 38 publications

References 36 publications

Impacts of temperatures and phosphoric-acid modification to the physicochemical properties of biochar for excellent sulfadiazine adsorption

Impacts of temperatures and phosphoric-acid modification to the physicochemical properties of biochar for excellent sulfadiazine adsorption

Antimicrobial dressing of silver sulfadiazine-loaded halloysite/cassava starch-based (bio)nanocomposites

Metal–organic frameworks towards bio-medical applications

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