Co-delivery of therapeutic protein and catalase-mimic nanoparticle using a biocompatible nanocarrier for enhanced therapeutic effect

Kim, Seoungkyun; Kim, Manse; Jung, Secheon; Kwon, Kiyoon; Park, Junyong; Kim, Sukhwan; Kwon, Inchan; Tae, Giyoong

doi:10.1016/j.jconrel.2019.07.038

Cited by 36 publications

(27 citation statements)

References 46 publications

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“…Some strategies have attempted to co‐deliver CAT‐like nanozymes and UOD into the blood of hyperuricemia animals in which CAT activity was used to reduce the toxic side effects of excess H 2 O 2 produced during UA oxidation. [ 49,50 ] However, the harsh preparation conditions in these strategies may cause the activity of the loaded enzyme to be lost, and adjusting the amount of protein/nanomaterial in the combination is challenging. In comparison, PEG‐ pero ‐nanozysome has both UOD‐like and CAT‐like activities, which may eliminate UA and H 2 O 2 through a cascade reaction by itself, thereby treating hyperuricemia more safely and efficiently.…”

Section: Resultsmentioning

confidence: 99%

“…Notably, the blood half‐life of pero ‐nanozysome was determined to be 4.7 h (Figure S19a, Supporting Information), which was significantly higher than the reported blood half‐life of UOD (1.3 h). [ 50 ] making pero ‐nanozysome to retain a longer lasting catalytic effect than UOD in vivo. These results indicated that the artificial PEG‐ pero ‐nanozysome was effective in alleviating hyperuricemia.…”

Section: Resultsmentioning

confidence: 99%

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A Nanozyme‐Based Artificial Peroxisome Ameliorates Hyperuricemia and Ischemic Stroke

Zhang

Wang

et al. 2020

Adv Funct Materials

165

104

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Artificial peroxisome has drawn a lot of attentions for its usefulness in fabricating protocell system and great potential in treating diseases. However, it is still a significant challenge to prepare a practicable artificial peroxisome to complement multiple and stable functions under physiological condition. Herein, a novel strategy is reported to design an artificial peroxisome using a nanozyme to accommodate multiple enzyme‐like activities that mimics those enzymes in natural peroxisome. The enzymatic active sites are introduced into graphitized moieties on the shell of a hollow carbon nanozyme by doping iron and nitrogen to form Fe–N4 coordination and atomic Fe cluster. With Fe clusters as reversible cofactors and Fe–N4 as prosthetic group, the resulted carbon nanozyme exhibits stable and multiple peroxisomal‐like activities, including catalase, uricase, superoxide dismutase, peroxidase, and oxidase, which is referred as nanozyme‐based artificial peroxisome (pero‐nanozysome). This pero‐nanozysome shows therapeutic effect for treating hyperuricemia and protecting neurons from free radicals generated during ischemic stroke by employing the tandem activities of uricase‐catalase and superoxide‐dismutase‐catalase, respectively. This study indicates that the pero‐nanozysome is a promising candidate to design artificial peroxisome performing in vivo functions.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

A Nanozyme‐Based Artificial Peroxisome Ameliorates Hyperuricemia and Ischemic Stroke

Zhang

Wang

et al. 2020

Adv Funct Materials

165

104

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“…E.g., the resident mesenchymal stromal cells (MSCs) could be incorporated into the polymer gels. Kim et al [28] used endometrial mesenchymal stromal cells (dEMSCs) encapsulated in a HA hydrogel in a mouse model of uterine infertility. Two weeks after the injury, the fibrous tissue decreased and the endometrial thickness increased.…”

Section: Endometrium Regeneration On the Basis Of Of Gel-cell Scaffolmentioning

confidence: 99%

Biomimetics for treatment of endometrial pathologies: an overview

Konovalova¹,

Tsaregorodtseva²,

Полтавцева³

et al. 2020

CTT

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Secondary infertility among women in their childbearing age is one of sufficient problems in Russia. It is often caused by damage to the basal layer of endometrium when performing gynecological procedures, e.g., dilatation of uterine cavity, diagnostic curettage, cesarean section, uterine surgey, as well as consequences of complicated pregnancies. As a result, hypo-or hypermetriosis may develop, along with intrauterine adhesions (synechiae), leading to the development of Asherman's syndrome. Despite large amounts of medical data, there are no quite effective ways to treat secondary infertility. Currently, various biological polymers and composite materials based on biopolymers with incorporated active molecules, genetic substances, platelet-rich plasma, stem cells or microvesicles/exosomes of stem cells are used with some success for treatment of hypometriosis and Asherman's syndrome. Gel substances based on sodium hyaluronate, carboxymethylcellulose, polyethylene oxide, collagen and others are certified for clinical use. Biopolymer gels serve, on the one hand, as the materials separating the uterine walls (barrier function), and, on the other hand, they work as carriers of biologically active molecules and cells. Biomimetics can stimulate the regeneration and normalization of endometrium at different efficiency rates, thus promoting restoration of reproductive capacity. Biomimetic-based therapies are under investigation. The present review provides data on treatment efficiency of endometrial disorders by means of biotherapeutic approaches.

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“…As a local therapy, there are difficulties using surgical treatment to eliminate infiltrating and metastatic tumors, while chemotherapy often results in serious side effects, including organ damage, nausea, vomiting, leukopenia, and anemia, as well as limited drug accumulation in deep tumors that can lead to drug resistance after repeated treatment [7][8][9]. Recently, methods to minimize the side effects of chemotherapy on normal tissues have attracted widespread attention [10][11][12][13]. Multifunctional drug delivery systems (DDSs) act as drug carriers that are designed to deliver a sufficient dose of a drug to the tumor area at the required rate, and are widely used today [9,14,15].…”

Section: Introductionmentioning

confidence: 99%

Polymeric Drug Delivery System Based on Pluronics for Cancer Treatment

Qiu

Yin

et al. 2021

Molecules

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Pluronic polymers (pluronics) are a unique class of synthetic triblock copolymers containing hydrophobic polypropylene oxide (PPO) and hydrophilic polyethylene oxide (PEO) arranged in the PEO-PPO-PEO manner. Due to their excellent biocompatibility and amphiphilic properties, pluronics are an ideal and promising biological material, which is widely used in drug delivery, disease diagnosis, and treatment, among other applications. Through self-assembly or in combination with other materials, pluronics can form nano carriers with different morphologies, representing a kind of multifunctional pharmaceutical excipients. In recent years, the utilization of pluronic-based multi-functional drug carriers in tumor treatment has become widespread, and various responsive drug carriers are designed according to the characteristics of the tumor microenvironment, resulting in major progress in tumor therapy. This review introduces the specific role of pluronic-based polymer drug delivery systems in tumor therapy, focusing on their physical and chemical properties as well as the design aspects of pluronic polymers. Finally, using newer literature reports, this review provides insights into the future potential and challenges posed by different pluronic-based polymer drug delivery systems in tumor therapy.

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Co-delivery of therapeutic protein and catalase-mimic nanoparticle using a biocompatible nanocarrier for enhanced therapeutic effect

Cited by 36 publications

References 46 publications

A Nanozyme‐Based Artificial Peroxisome Ameliorates Hyperuricemia and Ischemic Stroke

A Nanozyme‐Based Artificial Peroxisome Ameliorates Hyperuricemia and Ischemic Stroke

Biomimetics for treatment of endometrial pathologies: an overview

Polymeric Drug Delivery System Based on Pluronics for Cancer Treatment

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