Co-delivery of Wnt7a and muscle stem cells using synthetic bioadhesive hydrogel enhances murine muscle regeneration and cell migration during engraftment

Han, Woojin M.; Mohiuddin, Mahir; Anderson, Shannon E.; Garcı́a, Andrés J.; Jang, Young C.

doi:10.1016/j.actbio.2019.06.025

Cited by 47 publications

(49 citation statements)

References 34 publications

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“…The major limitations are typically weaker cell adhesion compared to hydrogels based on natural polymers and the risk of the stimulation of a foreign body reaction by the polymer or its degradation products [ 2 , 124 ]. Synthetic polymers such as poly-L-lactic acid (PLLA) [ 155 , 156 ], poly(lactic-co-glycolic acid) (PLGA) [ 156 ], PCL [ 157 , 158 , 159 , 160 ], poly(ethylene glycol) (PEG) [ 161 , 162 , 163 ] and their copolymers [ 164 ], and various polyurethanes (PU) [ 165 , 166 , 167 , 168 ] are preferred for musculoskeletal tissue engineering. Among the synthetic polymers, elastomers, such as polydimethylsiloxane (PDMS), have been extensively used for the 2D fabrication of tissue-engineered muscle thin films due to their excellent biostability and tunable elasticity [ 169 , 170 ].…”

Section: Biomaterials For the Transplantation Of Striated Muscle Cellsmentioning

confidence: 99%

Current Strategies for the Regeneration of Skeletal Muscle Tissue

Alarçin

Bal‐Öztürk

Avcı

et al. 2021

IJMS

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Traumatic injuries, tumor resections, and degenerative diseases can damage skeletal muscle and lead to functional impairment and severe disability. Skeletal muscle regeneration is a complex process that depends on various cell types, signaling molecules, architectural cues, and physicochemical properties to be successful. To promote muscle repair and regeneration, various strategies for skeletal muscle tissue engineering have been developed in the last decades. However, there is still a high demand for the development of new methods and materials that promote skeletal muscle repair and functional regeneration to bring approaches closer to therapies in the clinic that structurally and functionally repair muscle. The combination of stem cells, biomaterials, and biomolecules is used to induce skeletal muscle regeneration. In this review, we provide an overview of different cell types used to treat skeletal muscle injury, highlight current strategies in biomaterial-based approaches, the importance of topography for the successful creation of functional striated muscle fibers, and discuss novel methods for muscle regeneration and challenges for their future clinical implementation.

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Section: Biomaterials For the Transplantation Of Striated Muscle Cellsmentioning

confidence: 99%

Current Strategies for the Regeneration of Skeletal Muscle Tissue

Alarçin

Bal‐Öztürk

Avcı

et al. 2021

IJMS

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“…Interestingly, when Wnt7a was injected into the skeletal muscles of mdx (X chromosome‐linked muscular dystrophy) mice, which have dystrophin mutation, an increased number of SCs, accompanied by induced hypertrophy of myofibers and enhanced muscle strength, were observed 74,75 . Recently, it has been reported that the codelivery of Wnt7a and SCs by using polyethylene glycol hydrogel enhances expansion and migration of SCs during skeletal muscle regeneration 76 . Therefore, it can be envisaged that noncanonical Wnt signaling activated by Wnt7a might be effective for the treatment of DMD.…”

Section: Ror‐mediated Signaling In the Skeletal Musclesmentioning

confidence: 99%

“…74,75 Recently, it has been reported that the codelivery of Wnt7a and SCs by using polyethylene glycol hydrogel enhances expansion and migration of SCs during skeletal muscle regeneration. 76 Therefore, it can be envisaged that noncanonical Wnt signaling activated by Wnt7a might be effective for the treatment of DMD.…”

Section: Skeletal Muscle Diseasesmentioning

confidence: 99%

Role of noncanonical Wnt ligands and Ror‐family receptor tyrosine kinases in the development, regeneration, and diseases of the musculoskeletal system

Kamizaki

Endo

Minami

et al. 2020

Developmental Dynamics

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The Ror-family receptor tyrosine kinases (RTKs), consisting of Ror1 and Ror2, play crucial roles in morphogenesis and formation of various tissues/organs, including the bones and skeletal muscles, the so-called musculoskeletal system, during embryonic development, by acting as receptors or coreceptors for a noncanonical Wnt protein Wnt5a. Furthermore, several lines of evidence have indicated that Ror1 and/or Ror2 play critical roles in the regeneration and maintenance of the musculoskeletal system in adults. Considering the

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“…Satellite cells are known to reside in specific niches [ 151 ] and aid in muscle regeneration [ 152 ], yet lack extended migratory capabilities. Further underlining this cell–cell interactive niche is the necessity for an intact immune system.…”

Section: Multicellular Environment For Muscle Tissue Engineeringmentioning

confidence: 99%

Next Stage Approach to Tissue Engineering Skeletal Muscle

et al. 2020

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Large-scale muscle injury in humans initiates a complex regeneration process, as not only the muscular, but also the vascular and neuro-muscular compartments have to be repaired. Conventional therapeutic strategies often fall short of reaching the desired functional outcome, due to the inherent complexity of natural skeletal muscle. Tissue engineering offers a promising alternative treatment strategy, aiming to achieve an engineered tissue close to natural tissue composition and function, able to induce long-term, functional regeneration after in vivo implantation. This review aims to summarize the latest approaches of tissue engineering skeletal muscle, with specific attention toward fabrication, neuro-angiogenesis, multicellularity and the biochemical cues that adjuvate the regeneration process.

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Co-delivery of Wnt7a and muscle stem cells using synthetic bioadhesive hydrogel enhances murine muscle regeneration and cell migration during engraftment

Cited by 47 publications

References 34 publications

Current Strategies for the Regeneration of Skeletal Muscle Tissue

Current Strategies for the Regeneration of Skeletal Muscle Tissue

Role of noncanonical Wnt ligands and Ror‐family receptor tyrosine kinases in the development, regeneration, and diseases of the musculoskeletal system

Next Stage Approach to Tissue Engineering Skeletal Muscle

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