Co‐existent cutaneous cryptococcosis of the forearm and cutaneous alternariosis of the leg in patient with metastatic thymoma

Courville, P.; Favennec, Loïc; Viacroze, C.; Barrel, A.; Young, Philip; Abboud, Philippe; Thomine, E; Metayer, J; Nouvet, G

doi:10.1046/j.0303-6987.2001.00035.x

Cited by 12 publications

(4 citation statements)

References 20 publications

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“…The PubMed search resulted in 545 manuscripts, 137 of which contained unique and relevant patient data and fulfilled the inclusion and exclusion criteria . These publications included a total of 581 cases of cryptococcal disease in cancer patients.…”

Section: Methodsmentioning

confidence: 99%

Cryptococcus neoformans infection in malignancy

Schmalzle

Buchwald

Gilliam

et al. 2016

Mycoses

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Cryptococcosis is an opportunistic invasive fungal infection that is well described and easily recognised when it occurs as meningitis in HIV-infected persons. Malignancy and its treatment may also confer a higher risk of infection with Cryptococcus neoformans, but this association has not been as well described. A case of cryptococcosis in a cancer patient is presented, and all cases of coincident C. neoformans infection and malignancy in adults published in the literature in English between 1970 and 2014 are reviewed. Data from these cases were aggregated in order to describe the demographics, type of malignancy, site of infection, clinical manifestations, treatment and outcomes of cryptococcosis in patients with cancer. Haematologic malignancies accounted for 82% of cases, with lymphomas over-represented compared to US population data (66% vs. 53% respectively). Cryptococcosis was reported rarely in patients with solid tumours. Haematologic malignancy patients were more likely to have central nervous system (P < 0.001) or disseminated disease (P < 0.001), receive Amphotericin B as part of initial therapy (P = 0.023), and had higher reported mortality rates than those with solid tumours (P = 0.222). Providers should have heightened awareness of the possibility of cryptococcosis in patients with haematologic malignancy presenting with infection.

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Section: Methodsmentioning

confidence: 99%

Cryptococcus neoformans infection in malignancy

Schmalzle

Buchwald

Gilliam

et al. 2016

Mycoses

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“…The skin is involved in 10-20 % of cases [20]. Diagnosis is achieved after identifying C. neoformans on biopsy, culture, or histological examination showing the spherical budding yeast within edema and a polymorphous inflammatory infiltrate [21]. Treatment consists of a course lipid-based amphotericin therapy or oral fluconazole, but in severe cases, life-long maintenance therapy is required.…”

Section: Cutaneous Cryptococcal Infectionmentioning

confidence: 99%

“…Treatment consists of a course lipid-based amphotericin therapy or oral fluconazole, but in severe cases, life-long maintenance therapy is required. Risk factors are multiple and include the following: coexisting HIV infection, corticosteroid therapy, malignancy, autoimmune disease, and immune system disorder with CD4+ lymphopenia [21].…”

Section: Cutaneous Cryptococcal Infectionmentioning

confidence: 99%

Dermatologic Infections in Cancer Patients

Gandhi

Brieva²,

Lacouture

2014

Infectious Complications in Cancer Patients

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Dermatologic infections are among the most commonly experienced complications of cancer and anti-cancer therapy. Alterations in host immune function secondary to the underlying malignant process and/or its treatment have been linked to an increase in the risk of infections. The skin and its appendages (i.e., hair and nails) represent the first line of defense against infectious microorganism; its dysfunction as a physical barrier and an immunologic organ in cancer patients leads to an increased susceptibility to infectious organisms. Moreover, a cancer patient's vulnerable state facilitates dissemination of infections to other sites, secondarily involving the skin. This chapter delineates dermatologic infections that are unique to cancer patients as a result of their underlying malignancies and associated comorbidities as well as those resulting from antineoplastic therapies.

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“…Weil die abgerundeten Elemente häufig unpigmentiert sind, kann die Alternariose zunächst als Kryptokokkose [28,30] oder als Infektion durch andere Hefen fehldiagnostiziert werden. Die Gomorri-Grocott-Färbung kann auch kleinere Hyphen besser sichtbar machen und daher auch zu der prognostisch wichtigen Abgrenzung beitragen [3], jedoch kön-nen beide Erkrankungen auch parallel auftreten [5]. Die Zellwände können bräunlich gefärbt sein, hyaline Zellwände -wie in unseren beiden Fallbeschreibungen -schließen eine Phäohyphomykose jedoch nicht aus.…”

Section: Diagnostikunclassified

Kutane Alternariose

et al. 2004

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Localized skin infections caused by the pigmented fungi of the genus Alternaria are being increasingly observed. In the past, primarily patients receiving long-term glucocorticoid therapy were likely to have this mycosis, which is commonly traumatic, but now it is frequently encountered in organ transplantation patients. Possible therapeutic options and differential diagnosis are discussed by means of two case reports--a female renal transplant patient infected by A. alternata and a patient with iatrogenic Cushing syndrome infected by A. infectoria. Histopathological differentiation from other fungal infections may be difficult but is of therapeutic and prognostic significance. Finding short hyphae in tissue sections is an important clue. Since A. infectoria shows little conidial growth in culture, rDNA ITS sequencing offers another diagnostic possibility. Therapy has not yet been standardized. Along with surgical intervention, systemic itraconazole is the usual choice.

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Co‐existent cutaneous cryptococcosis of the forearm and cutaneous alternariosis of the leg in patient with metastatic thymoma

Abstract: This observation underlines the fact that the possible co-existence of several rare infections in immunocompromised patients should take into consideration pathogen identification in order to adapt the therapy to individual patient requirements.

Cited by 12 publications

References 20 publications

Cryptococcus neoformans infection in malignancy

Cryptococcus neoformans infection in malignancy

Dermatologic Infections in Cancer Patients

Kutane Alternariose

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