Co-existent erythromelanosis follicularis faciei et colli and erythroses pigmentosa mediofacialis in a patient of generalized keratosis pilaris - A rare report in a young female

Keratosis Pilaris-like Eruption during Treatment of Chronic Myeloid Leukemia with Tyrosine Kinase Inhibitors: Literature Review and Report of a Case Related to Imatinib

“…The onset of the reaction varied from a few days to 6 months. Some patients had asymptomatic lesions without relevant inflammatory signs or hair thinning [35,36,41,42], as in our case, with similar histopathological findings that were available for two patients [35,41]. In fact, in both reports [35,41], histopathological features were suggestive of KP, being characterized by keratotic plugs within the follicle and mild lymphocytic infiltration without fibrosis.…”

“…The absence of cross-intolerance between imatinib and other TKIs was confirmed by other reports [36,37,[39][40][41]. In such cases, imatinib had been stopped because of resistance or intolerance [36,37,[39][40][41] (Table 1). Among the patients examined by Patel et al [24], two patients had KP-like lesions with both dasatinib and nilotinib, whereas in another patient the rash resolved after switching from nilotinib to dasatinib.…”

“…Interestingly, among the nine patients with KP-like lesions examined by Patel et al, six of them had previously been treated with imatinib without experiencing similar reactions [24]. The absence of cross-intolerance between imatinib and other TKIs was confirmed by other reports [36,37,[39][40][41]. In such cases, imatinib had been stopped because of resistance or intolerance [36,37,[39][40][41] (Table 1).…”

“…Table 1 summarizes the most important information contained in such reports [22][23][24][35][36][37][38][39][40][41][42]. Many reactions were observed in patients treated with nilotinib, a few reactions during treatment with dasatinib, whereas fewer cases were reported with ponatinib.…”

“…In the publications cited in Table 1, information about medical history was not constantly outlined. However, the reported data indicated no significant personal and/or familial history of KP and/or other skin disorders [24,[35][36][37][38]40,41]. The onset of the reaction varied from a few days to 6 months.…”