Co-Infection of Malaria and Hepatitis B Virus in Port Harcourt, Rivers State, Nigeria

Abah, A. E.; Udoidang, Idara N

doi:10.5812/iji.97033

Cited by 8 publications

(21 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The 6.3% prevalence for hepatitis B observed in this study is lower than the 19.0% prevalence reported by Kolawole and Kana (15) among febrile patients attending general and specialty hospitals in Ilorin, Kwara State. Although lower prevalence rates have been reported for hepatitis B in some parts of Nigeria (15), the hepatitis B prevalence recorded in this study is consistent with the 6.5% and 6.0% rates earlier reported from the Northern and Southern parts of Nigeria, respectively (16)(17)(18). This consistency may be due to the similarity in the socio-demographic characteristics and laboratory methods used for the analyses.…”

Section: Discussionsupporting

confidence: 90%

See 1 more Smart Citation

Co-Infection of Hepatitis B and Human Papilloma Viruses in Two Nigerian States

Abubakar

Ajuwon

2020

Int J Infect

View full text Add to dashboard Cite

Background: Hepatitis B virus (HBV) and human papillomavirus (HPV) infections remain a major public health problem in sub-Saharan countries including Nigeria. Methods: The study investigated the prevalence of HBV, HPV, and their co-infection in 510 outpatients of two major hospitals in both Kwara and Ondo States, Nigeria, employing the use of rapid serology assay diagnostic kit for HBV and HPV Enzyme-Linked Immunosorbent assay (ELISA) kit. Results: The overall preponderance rate of both infections was observed to be 11.4%, including 6.3% hepatitis B and 5.1% HPV. The coinfection prevalence was observed to be 0.58%. Females were more infected with HBV (6.8%) and HPV (5.7%) than male counterparts with 5.3% and 4.3%, respectively. Furthermore, married-single subjects had a higher rate of co-infection (1.4%) than their married counterparts (0.56%). The rate of infection between male and female genders was not significantly different (P > 0.05). However, the prevalence of HPV was statistically higher among married-single subjects (7.2%) (P < 0.05). The HBV and co-infection prevalence rates were statistically higher among married-single subjects with 8.7% and 1.4%, respectively. Conclusions: The prevalence of HBV and co-infection with HPV observed in this study indicates the public health threats posed by these infections and further establishes the need for the Nigerian Health System to strengthen domestic initiatives that are strategically geared towards eliminating hepatitis and improving access to affordable diagnostics, enabling linkage to care and treatment of infected individuals.

show abstract

Section: Discussionsupporting

confidence: 90%

“…Of many types of HPV, about 30 types can infect the genital tract through sexual contact. Genital HPV 16,18,31, and 45 account for more than 90% of cervical carcinomas (2)(3)(4). Cervical cancer and premalignant lesions make major problems in women's health.…”

Section: Introductionmentioning

confidence: 99%

Co-Infection of Hepatitis B and Human Papilloma Viruses in Two Nigerian States

Abubakar

Ajuwon

2020

Int J Infect

View full text Add to dashboard Cite

show abstract

“…When assessing the individual studies, Plasmodium spp. and HBV co-infection was prevalent in most tropical and sub-Saharan African countries, particularly Nigeria [10,15,16,26,[28][29][30][31][33][34][35][36], Ghana [8,23,25], Central African Republic [24], and The Gambia [11]. The pooled prevalence estimate of Plasmodium spp.…”

Section: Discussionmentioning

confidence: 99%

“…Finally, 9 studies [8][9][10][23][24][25][26][27][28] were included in the quantitative synthesis. Thirteen additional studies [11,[14][15][16][17][29][30][31][32][33][34][35][36] were identified and included after reviewing the references of the nine included studies and additional searches of other databases. The main characteristics of the 22 included studies [8-11, 14-17, 23-36] are presented in Table 1.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…One study was conducted during 2013-2015, while five studies [8,15,27,33,36] did not specify the year of study conducted. Among the 22 included studies, approximately half of the studies (12/22; 54.5%) were carried out in Nigeria [10,15,16,26,[28][29][30][31][33][34][35][36], while the remaining 10 studies were carried out in Brazil [9,14,17,32], Ghana [8,23,25], Central African Republic [24], Italy [27], and The Gambia [11]. Twenty of the 22 included studies used cross-sectional designs, while two studies used retrospective designs.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence of and risk factors for Plasmodium spp. co-infection with hepatitis B virus: a systematic review and meta-analysis

Kotepui

2020

Malar J

View full text Add to dashboard Cite

Background Plasmodium spp. and hepatitis B virus (HBV) are among the most common infectious diseases in underdeveloped countries. This study aimed to determine the prevalence of Plasmodium spp. and HBV co-infection in people living in endemic areas of both diseases and to assess the risk factors related to this co-infection. Methods The PubMed, Web of Science, and Scopus databases were searched. Observational cross-sectional studies and retrospective studies assessing the prevalence of Plasmodium species and HBV co-infection were examined. The methodological quality of the included studies was assessed with the Newcastle-Ottawa Scale (NOS), a tool for assessing the quality of nonrandomized studies in meta-analyses, and heterogeneity among the included studies was assessed with Cochran's Q test and the I2 (inconsistency) statistic. The pooled prevalence of the co-infection and its 95% confidence interval (CI) were estimated using the random-effects model, depending on the amount of heterogeneity there was among the included studies. The pooled odds ratio (OR) represented the difference in qualitative variables, whereas the pooled mean difference (MD) represented the difference in quantitative variables. Meta-analyses of the potential risk factors for Plasmodium spp. and HBV co-infection, including patient age and gender, were identified and represented as pooled odds ratios (OR) and 95% CIs. Publication bias among the included studies was assessed by visual inspection of a funnel plot to search for asymmetry. Results Twenty-two studies were included in the present systematic review and meta-analysis. Overall, the pooled prevalence estimate of Plasmodium spp. and HBV co-infection was 6% (95% CI 4–7%, Cochran's Q statistic < 0.001, I2: 95.8%), with prevalences of 10% in Gambia (95% CI: 8–12%, weight: 4.95%), 8% in Italy (95% CI 5–12%, weight: 3.8%), 7% in Nigeria (95% CI 4–10%, weight: 53.5%), and 4% in Brazil (95% CI 2–5%, weight: 19.9%). The pooled prevalence estimate of Plasmodium spp. and HBV co-infection was higher in studies published before 2015 (7%, 95% CI 4–9%, Cochran's Q statistic < 0.001, I2: 96%) than in those published since 2015 (3%, 95% CI 1–5%, Cochran's Q statistic < 0.001, I2: 81.3%). No difference in age and risk of Plasmodium spp. and HBV co-infection group was found between the Plasmodium spp. and HBV co-infection and the Plasmodium monoinfection group (p: 0.48, OR: 1.33, 95% CI 0.60–2.96). No difference in gender and risk of Plasmodium spp. and HBV co-infection group was found between the Plasmodium spp. and HBV co-infection and HBV co-infection group and the Plasmodium monoinfection group (p: 0.09, OR: 2.79, 95% CI 0.86–9.10). No differences in mean aspartate aminotransferase (AST), mean alanine aminotransferase (ALT), or mean total bilirubin levels were found (p > 0.05) between the Plasmodium spp. and HBV co-infection group and the Plasmodium monoinfection group. Conclusions The present study revealed the prevalence of Plasmodium spp. and HBV co-infection, which will help in understanding co-infection and designing treatment strategies. Future studies assessing the interaction between Plasmodium spp. and HBV are recommended.

show abstract

Hepatitis B and Asymptomatic Malaria Infection among Pregnant Women in a Semiurban Community of North-Central Nigeria

Omatola

Okolo

2021

Journal of Environmental and Public Health

View full text Add to dashboard Cite

Background. The overlap of malaria and Hepatitis B Virus (HBV) infections present a major threat to public health throughout endemic countries of tropical and sub-Saharan Africa. There is a paucity of data on the prevalence and associated factors of malaria and HBV infections among pregnant women in Ejule, a semiurban area of Nigeria. Therefore, the current study was designed to assess the seroprevalence of malaria and HBV among pregnant women attending antenatal clinics in Ejule Metropolis. Materials and Methods. In a hospital-based cross-sectional study, blood samples collected from 200 apparently healthy pregnant women at the Ilemona Clinic were screened for Plasmodium falciparum (P. falciparum) and HBsAg using histidine-rich protein 2 (HRP2) and hepatitis B surface antigen (HBsAg) rapid diagnostic tests (RDTs), respectively. Relevant sociodemographic and putative risk factor information was obtained with structured questionnaires. Results. The prevalence of the infections was 44 (22%), 5 (2.5%), and 1 (0.5%) for P. falciparum monoinfection and HBV monoinfection and coinfection, respectively. Single and concurrent infections peaked at ages 31–40 years but decreased with older ages. High P. falciparum, 31 (59.62%), and HBV 2 (3.85%) infection were observed among those without formal education. Contrary to ages, occupation, and knowledge of infection, malaria parasitemia differed significantly with lower educational qualification ( p ≤ 0.001 ), being single ( p = 0.001 ), and inconsistent use of insecticide-treated bed nets (ITNs) ( p = 0.04 , OR = 5, CI: 0.10–0.47). History of blood donation (OR = 5, p = 0.04 , CI: 1.10–32.80) and multiple sex partners (OR = 11.9, p = 0.01 , CI: 0.01–0.93) were found to be significantly associated with hepatitis B surface antigenemia rate during pregnancy. No evidence of HBV infection was observed in women with a history of HBV vaccination. Conclusions. Malaria is still highly prevalent among pregnant women due to high illiteracy and noncompliance to using ITNs. Therefore, routine screening and educating pregnant mothers are crucial in eliminating malaria in endemic settings. The low rate of hepatitis B and coinfection with malaria shows that further improvement in HBV vaccination could considerably reduce the disease burden among pregnant women.

show abstract

Co-Infection of Malaria and Hepatitis B Virus in Port Harcourt, Rivers State, Nigeria

Cited by 8 publications

References 12 publications

Co-Infection of Hepatitis B and Human Papilloma Viruses in Two Nigerian States

Co-Infection of Hepatitis B and Human Papilloma Viruses in Two Nigerian States

Prevalence of and risk factors for Plasmodium spp. co-infection with hepatitis B virus: a systematic review and meta-analysis

Hepatitis B and Asymptomatic Malaria Infection among Pregnant Women in a Semiurban Community of North-Central Nigeria

Contact Info

Product

Resources

About