Co-infection of SARS-CoV-2 and Bordetella bronchiseptica in a young man with idiopathic non-cystic bronchiectasis and vitamin D3 deficiency

Abstract

This is the first reported case, to our knowledge, of co-infection of Bordetella bronchiseptica and SARS-CoV-2 in a young patient with underlying idiopathic bronchiectasis and vitamin D 3 deficiency that was treated successfully with a combination therapeutic regime integrating doxycycline, empiric therapies for COVID-19, vitamin D supplementation, and supportive ICU care. Large prospective studies are required to investigate further the role of co-infections in COVID-19 patients with bronchiectasis. Randomized control trials should examine the putative beneficial role of vitamin D supplementation in patients with COVID-19.

Microbiome Analysis for Wastewater Surveillance during COVID-19

“…marseillensis and P. pectinovora ), supporting the hypothesis that the resident microbial communities of the gastrointestinal and respiratory tracts can act as modulators of local and systemic inflammatory activity, e.g., the gut-lung axis ( 65 ). Remarkably, several opportunistic species shown to have significant correlation with SARS-CoV-2 RNA in wastewater, including Bordetella bronchiseptica ( 66 ), Enterobacter cloacae ( 67 ), Leclercia adecarboxylata ( 68 ), and Pseudomonas monteilii ( 69 ). These have been identified clinically as coinfecting microorganisms during COVID-19.…”

Exacerbation of bronchiectasis by Pseudomonas putida complicating COVID‑19 disease: A case report

“…Lopinto et al (16) reported the first case of acute exacerbation of bronchiectasis, precipitated by COVID-19 disease and complicated by severe hemoptysis. In addition, Faqihi et al (17) describe a case of co-infection of Bordetella bronchiseptica and novel coronavirus in a young patient with idiopathic bronchiectasis leading to critical illness and requirement of mechanical ventilation. One may hypothesize that the novel virus triggers acute bronchial inflammation and exacerbation of the chronic disease of airways.…”

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Bordetella bronchiseptica Co-Infection in a Stem Cell Transplant Patient

“…For example, our patient’s chronic cough began approximately a month before she developed shortness of breath, an important consideration given that chronic cough has been previously associated with human B. bronchiseptica infections [ 11 , 12 ]. Additionally, our case represents at least the second patient diagnosed with B. bronchiseptica pneumonia while receiving nivolumab [ 13 ] and the fourth documented patient co-infected with COVID-19 and B. bronchiseptica [ 14 , 15 , 16 ]. Clinical characteristics of patients co-infected with COVID-19 and B. bronchiseptica are summarized in Table 2 .…”