Co-infection with HTLV-1 is associated with a shorter survival time for HIV-1-infected patients in Bahia, Brazil

Brites, Carlos; Alencar, Roberta Carvalho de; Gusmão, R. H. P.; Pedroso, Célia; Netto, Eduardo Martins; Pedral-Sampaio, Diana; Badaró, Roberto

doi:10.1097/00002030-200110190-00023

Cited by 63 publications

(58 citation statements)

References 6 publications

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“…HTLV-I shares a similar tropism with HIV and has indeed been suggested to accelerate progression of HIV. 16 However, syphilis did not follow this pattern because it only affected the activated T cell pool. KSHV on the other hand decreased naive CD4 T cells without affecting T cell activation.…”

Section: Discussionmentioning

confidence: 99%

Alterations in T Cell Subsets in Human Immunodeficiency Virus–Infected Adults with Co-infections in Southern Mozambique

Naniche

Letang²,

Nhampossa³

et al. 2011

The American Society of Tropical Medicine and Hygiene

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Abstract. T cell activation and depletion of naive T cells are hallmarks of human immunodeficiency virus (HIV) pathogenesis. This study explored the relationships between certain co-infections (including syphilis, hepatitis B and C, human T cell lymphotrophic viruses I and II [HTLV-I/II], Kaposi sarcoma-associated herpesvirus [KSHV], Plasmodium falciparum malaria, and tuberculosis), and levels of activated CD8 and CD4 T cell subsets as well as naive and memory CD4 T cells in HIV-infected adults in a rural area of southern Mozambique. We found that syphilis infection and to a lesser extent HTLV-I/II seropositivity were independently associated with higher CD8 T cell activation (CD8+ CD38+ HLA-DR+) whereas only syphilis was associated with higher CD4 T cell activation. Furthermore, KSHV and HTLV-I/II seropositivities were independently associated with a lower percentage of naive CD4 T cells (CD4+ CD45RA+ CD62L+). These results highlight the importance of screening and prompt treatment of syphilis, and raise questions as to whether HIV-positive persons with certain chronic viral co-infections should initiate combined antiretroviral therapy at higher CD4 cell counts.

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Section: Discussionmentioning

confidence: 99%

Alterations in T Cell Subsets in Human Immunodeficiency Virus–Infected Adults with Co-infections in Southern Mozambique

Naniche

Letang²,

Nhampossa³

et al. 2011

The American Society of Tropical Medicine and Hygiene

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“…Several retrospective studies have evaluated the effect of HTLV-I infection on survival of HIV patients 4,6,12,16,18,22 . Most of them suggested that HIV/HTLV-I co-infection shortens the survival of these patients 6,12,16,18,22 .…”

Section: Discussionmentioning

confidence: 99%

“…Most of them suggested that HIV/HTLV-I co-infection shortens the survival of these patients 6,12,16,18,22 . In contrast, a recent longitudinal retrospective study showed that the HTLV-I infection in persons with HIV was not associated with a shorter survival 4 .…”

Section: Discussionmentioning

confidence: 99%

“…As it has been discussed 2,4,7 , incomplete demographic, laboratory and treatment data, lack of differentiation between HTLV-I and HTLV-II 12,16,18 , and the lack of adjustment for confounding variables 6,16 are key elements that make difficult the interpretation of the effect of HTLV-I on the survival of HIV patients. Moreover, special populations (e.g.…”

Section: Discussionmentioning

confidence: 99%

“…All matched controls were chosen within one month of the presentation of the cases. Assuming a proportion of 50% of exposed patients and 80% of unexposed patients alive at 48 months 6 , a 20% of lost to follow-up, an alpha level of 0.05 and a power of 90%, we needed at least to have 43 exposed patients and 86 unexposed patients.…”

Section: Methodsmentioning

confidence: 99%

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HTLV- I infection is not associated with a higher risk of death in peruvian HIV-infected patients

Collins

Hernández

Hidalgo

et al. 2009

Rev. Inst. Med. trop. S. Paulo

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Limited and contradictory information exists regarding the prognosis of HIV/HTLV-I co-infection. Our goal was to estimate the effect of HTLV-I infection on mortality in HIV-infected patients at a HIV reference center in Peru. We studied a retrospective cohort of HIV-infected patients, who were exposed or unexposed to HTLV-I. Exposed patients were Western Blot (WB) positive for both retroviruses. Unexposed patients were WB positive for HIV, and had least one negative EIA for HTLV-I. These were selected among patients who entered our Program immediately before and after each exposed patient, between January 1990 and June 2004. Survival time was considered between the diagnosis of exposure to HTLV-I and death or censoring. Confounding variables were age, gender, baseline HIV clinical stage, baseline CD4+ T cell count, and antiretroviral therapy. We studied 50 exposed, and 100 unexposed patients. Exposed patients had a shorter survival compared to unexposed patients [median survival: 47 months (95% CI: 17-77) vs. 85 months (95% CI: 70-100), unadjusted p = 0.06]. Exposed patients had a higher rate of mortality compared to unexposed patients (HIV/HTLV-I (24/50 [48%]) vs. HIV only (37/100 [37%]), univariable p = 0.2]. HTLV-I exposure was not associated to a higher risk of death in the adjusted analysis: HR: 1.2 (0.4-3.5). AIDS clinical stage and lack of antiretroviral therapy were associated to a higher risk of dying. In conclusions, HTLV-I infection was not associated with a higher risk of death in Peruvian HIV-infected patients. Advanced HIV infection and lack of antiretroviral therapy may explain the excess of mortality in this population.

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Human T‐cell lymphotropic virus antibody prevalence in HIV‐1‐infected individuals attending a sexual health clinic in South‐East London

Cooke

Geretti

Zuckerman

2005

Journal of Medical Virology

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Human immunodeficiency virus (HIV) and human T-cell lymphotropic virus (HTLV) are both retroviruses with similar routes of transmission. A number of reports suggest variable clinical outcomes in HIV and HTLV co-infected individuals. There is no published information regarding the prevalence of HIV and HTLV co-infection in the UK. We therefore carried out an unlinked anonymised retrospective study to investigate the prevalence of HTLV co-infection in HIV infected patients attending a sexual health clinic in South-East London. We identified sera from 777 HIV-1 positive adults (504 male, 273 female) who had attended our sexual health clinic between January 2000 and March 2001. Serum samples stored at -20 degrees C were initially tested by HTLV-1 and HTLV-2 antibody enzyme-linked immunoassay (EIA). An immunoblot assay was carried out on reactive samples to discriminate between viral subtypes. Samples with indeterminate results were also analyzed by Western blot. The prevalence of HTLV antibody was 0.8% (five patients with HTLV-1 and one with HTLV-2). Four of the HTLV-1 co-infected patients were females born abroad, of Black African or Caribbean origin. The other HTLV-1-infected patient was a male in the Black Other ethnic group born in the UK, demonstrating that transmission may occur outside recognized areas of high endemicity. The HTLV-2 co-infected individual was a White male born in Italy, and was likely to have been infected through intravenous drug use. The results suggest HTLV antibody screening should be considered in the local HIV infected population of south London.

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Co-infection with HTLV-1 is associated with a shorter survival time for HIV-1-infected patients in Bahia, Brazil

Cited by 63 publications

References 6 publications

Alterations in T Cell Subsets in Human Immunodeficiency Virus–Infected Adults with Co-infections in Southern Mozambique

Alterations in T Cell Subsets in Human Immunodeficiency Virus–Infected Adults with Co-infections in Southern Mozambique

HTLV- I infection is not associated with a higher risk of death in peruvian HIV-infected patients

Human T‐cell lymphotropic virus antibody prevalence in HIV‐1‐infected individuals attending a sexual health clinic in South‐East London

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