Co-morbidities among epilepsy patients: experience in Bangladesh

Chowdhury, Rajib Nayan; Hasan, Atm Hasibul; Rahman, Kazi Mohibur; Deb, Sudip Ranjan

doi:10.3329/bjmed.v24i2.20219

Cited by 1 publication

(2 citation statements)

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“…Huttenlocher & Hapke 23 found that the majority of children with uncontrollable seizures (61%) were mentally retarded and remission of seizures was much less frequent (1.5%/ year) in this group with mental retardation. One Bangladeshi study Chowdhury RN et al 15 showed that Mental retardation was more common and significantly associated (p=0.0001) with generalized epilepsy patients.…”

Section: Acknowledgementmentioning

confidence: 99%

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Neurodevelopmental Co morbidities of Poorly-Controlled Childhood Epilepsy: A Case-Control Study

Asaduzzaman¹,

Rahman

Hasan³

2021

Med. Today

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Introduction: The epilepsy associated co morbidities are often underestimated, consequently, undertreated. The aim of the present study was to determine neurodevelopmental co morbidities associated with poorly controlled childhood epilepsy. Materials and Methods: This retrospective study was performed from January 2007 to December 2008 at Paediatric Neurology outpatient department in Bangabandhu Sheikh Mujib Medical University, Dhaka, among the children with epilepsy of 7 months to 15 years age who had history of at least 6 months treatment with rational antiepileptic drugs daily with adequate compliance. There were two groups of patients; group 1, consisted of 50 poorly controlled epilepsy patients and group 2, comprised 50 well-controlled epilepsy patients. We retrospectively reviewed EEGs and medical records from these children. Features of neurolodevelopmental co morbidities were compared between the two groups. Results: In this study, initial EEG was abnormal significantly in poorly controlled group (OR= 5.27; p=0.025). Co morbidities- cerebral palsy, language and speech delay, motor delay, microcephaly and cognitive disability were significantly higher in poorly-controlled epilepsy group compared to well-controlled epilepsy group (60.0% vs. 24.0%, p <0.001; 74.0% vs. 38%, p <0.001; 72% vs. 40%, p <0.01; 60% vs. 30.0%, p <0.01; 70% vs 32%, p <0.001 respectively). Conclusion: The study showed several neurodevelopment co morbidities that can be identified early in the course of childhood epilepsy which can predict development of poor seizure control. Knowledge of these co morbidities will help us to discriminate our patient and can inform therapeutic choices. Medicine Today 2021 Vol.33(1): 65-70

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Section: Acknowledgementmentioning

confidence: 99%

“…This factor contributes to higher rates of uncontrollable seizures and neuropsychiatric complications. One Bangladeshi study showed that the neuropsychiatric, developmental and pain disorders are quite common co morbid conditions among epilepsy patients 15 .…”

Section: Introductionmentioning

confidence: 99%