Co-occurrence of mcr-1 and blaKPC-2 in a clinical isolate of Escherichia coli in Brazil

Dalmolin, Tanise Vendruscolo; Castro, Luiza Peres de; Mayer, Fabiana Quoos; Zavascki, Alexandre Prehn; Martins, Andreza Francisco; Lima-Morales, Daiana de; Barth, Afonso Luís

doi:10.1093/jac/dkx142

Cited by 29 publications

(15 citation statements)

References 8 publications

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“…Giani et al 13 , had observed an outbreak of colistin-resistant KPC-3-producing K. pneumoniae due to the deletion of mgrB gene. The presence of mcr-1 gene in carbapenemase-producing isolates had also been reported by some authors 14,15 .…”

supporting

confidence: 69%

Increased antimicrobial resistance in Klebsiella pneumoniae from a University Hospital in Rio Grande do Sul, Brazil

Lorenzoni

Rubert

Rampelotto

et al. 2018

Rev. Soc. Bras. Med. Trop.

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Introduction: The spread of multidrug-resistant Gram-negative bacilli is a health threat, limiting therapeutic options and increasing morbimortality rates. Methods: This study aimed to evaluate the antimicrobial susceptibility profile of 1805 Klebsiella pneumoniae isolates collected from Hospital Universitário de Santa Maria between January 2015 and December 2016. Results: Resistance to colistin (239.3%), meropenem (74.2%), ciprofloxacin (68%), gentamicin (35.1%), tigecycline (33.9%), imipenem (29.7%), ertapenem (26.8%), and amikacin (21.4%) was found increased. Conclusions: Infection control measures in the hospitals are necessary for reducing the spread of multidrug-resistant microorganisms and preventing efficacy loss of these drugs.

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supporting

confidence: 69%

Increased antimicrobial resistance in Klebsiella pneumoniae from a University Hospital in Rio Grande do Sul, Brazil

Lorenzoni

Rubert

Rampelotto

et al. 2018

Rev. Soc. Bras. Med. Trop.

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“…These mcr genes have been disseminated worldwide and were reported to coexist with many different resistance genes, especially carbapenem resistance genes (bla NDM , bla KPC , etc. ), resulting in the emergence of veritable "superbugs" which pose severe threats to human health [37][38][39][40][41]. To our knowledge, this study was the first nationwide surveillance report comparing the carriage of mcr-1 among CRE before and after use of polymyxin in clinical settings.…”

Section: Discussionmentioning

confidence: 91%

Colistin-resistance gene mcr in clinical carbapenem-resistant Enterobacteriaceae strains in China, 2014–2019

Huang

Dong

Shu

et al. 2020

Emerging Microbes & Infections

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To investigate whether introduction of colistin into the clinical settings selected colistin-resistant CRE, we performed molecular epidemiological study of 1868 CRE strains collected from different geographical locales in China during the period 2014-2019. 1755 (96.18%) isolates carried the carbapenemase genes bla KPC and bla NDM ; 14 Escherichia coli isolates (0.75%) carrying mcr-1 and bla NDM (MCR-CREC) were also identified. Importantly, the number and relative prevalence of MCR-CREC isolates increased from 5 (0.41%) to 9 (1.38%) after introduction of polymyxin into clinical practice. Consistently, results of genetic analysis indicated that MCR-CREC strains collected before December 2017 were genetically diverse, yet those collected after that date exhibited more closely related genetic profiles, indicating that specific MCR-CREC strains were rapidly selected as a result of increased usage of colistin in clinical settings. The resistance level of MCR-CREC isolates to colistin increased after the introduction of polymyxin into clinical use with the MIC to colistin from <2 mg/L in 80% strains to 2 mg/L in 100% strains. Further dissemination of MCR-CREC strains, which exhibit resistance to the last-line drugs of carbapenems and colistin, is expected to pose a severe threat to human health.

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“…In Brazil, mcr-1 has been consistently associated with IncX4 plasmids, both in E. coli and Salmonella sp. strains, isolated from animal, animal-derived food, and clinical and environmental sources [169][170][171][172][173][174]. Moreno et al published the complete sequence of a 32kb mcr1_IncX4 plasmid harbored by Salmonella sp.…”

Section: Colistin Resistance-mcrmentioning

confidence: 99%

Antimicrobial Resistance in Farm Animals in Brazil: An Update Overview

Rabello

Bonelli

Penna

et al. 2020

Animals

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In animal husbandry, antimicrobial agents have been administered as supplements to increase production over the last 60 years. Large-scale animal production has increased the importance of antibiotic management because it may favor the evolution of antimicrobial resistance and select resistant strains. Brazil is a significant producer and exporter of animal-derived food. Although Brazil is still preparing a national surveillance plan, several changes in legislation and timely programs have been implemented. Thus, Brazilian data on antimicrobial resistance in bacteria associated with animals come from official programs and the scientific community. This review aims to update and discuss the available Brazilian data on this topic, emphasizing legal aspects, incidence, and genetics of the resistance reported by studies published since 2009, focusing on farm animals and derived foods with the most global public health impact. Studies are related to poultry, cattle, and pigs, and mainly concentrate on non-typhoid Salmonella, Escherichia coli, and Staphylococcus aureus. We also describe legal aspects of antimicrobial use in this context; and the current occurrence of genetic elements associated with resistance to beta-lactams, colistin, and fluoroquinolones, among other antimicrobial agents. Data here presented may be useful to provide a better understanding of the Brazilian status on antimicrobial resistance related to farm animals and animal-derived food products.

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Co-occurrence of mcr-1 and blaKPC-2 in a clinical isolate of Escherichia coli in Brazil

Cited by 29 publications

References 8 publications

Increased antimicrobial resistance in Klebsiella pneumoniae from a University Hospital in Rio Grande do Sul, Brazil

Increased antimicrobial resistance in Klebsiella pneumoniae from a University Hospital in Rio Grande do Sul, Brazil

Colistin-resistance gene mcr in clinical carbapenem-resistant Enterobacteriaceae strains in China, 2014–2019

Antimicrobial Resistance in Farm Animals in Brazil: An Update Overview

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