Co‐overexpression of
            <scp>VEGF</scp>
            and Smad7 improved the therapeutic effects of adipose‐derived stem cells on neurogenic erectile dysfunction in the rat model

He, Lei; Yu, Tiannan; Xiao, Ying; Huang, Yeqing; Guan, Yangbo; Zhao, Fan; Ma, Limin

doi:10.1111/and.14538

Cited by 4 publications

(3 citation statements)

References 36 publications

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“…Some studies published in 2022 used modifications in stem cell preparation or co-interventions aiming to enhance their therapeutic effect. He et al evaluated the efficacy of ADSC co-modified with VEGF and Smad7 in a CNI rat model [ 42 ]. Erectile function in rats treated with co-modified ADSC was more distinctly recovered.…”

Section: Resultsmentioning

confidence: 99%

Stem Cell Therapy for Erectile Dysfunction: A Step towards a Future Treatment

Pérez-Aizpurua

Garranzo-Ibarrola

Simón-Rodríguez

et al. 2023

Life

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Background: The improvement of absent or partial response in the medical treatment of erectile dysfunction (ED) has led to the development of minimally invasive new treatment modalities in the field of regenerative medicine. Methods: A literature review on stem cell therapy for the treatment of ED was performed. We searched for the terms “erectile dysfunction” and “stem cell therapy” in PubMed and Clinicaltrials.gov. Literature searching was conducted in English and included articles from 2010 to 2022. Results: New treatment modalities for ED involving stem cell therapy are not only conceived with a curative intent but also aim to avoid unnecessary adverse effects. Several sources of stem cells have been described, each with unique characteristics and potential applications, and different delivery methods have been explored. A limited number of interventional studies over the past recent years have provided evidence of a safety profile in their use and promising results for the treatment of ED, although there are not enough studies to generate an appropriate protocol, dose or cell lineage, or to determine a mechanism of action. Conclusions: Stem cell therapy is a novel treatment for ED with potential future applications. However, most urological societies agree that further research is required to conclusively prove its potential benefit.

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Section: Resultsmentioning

confidence: 99%

Stem Cell Therapy for Erectile Dysfunction: A Step towards a Future Treatment

Pérez-Aizpurua

Garranzo-Ibarrola

Simón-Rodríguez

et al. 2023

Life

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show abstract

“…After sorting, we developed five general study categories, such as adipose-derived stem cells (ADSCs), mesenchymal stem cells (MSCs), urine-derived stem cells (USCs), placental stem cells (PSCs), muscle-derived stem cells (MDSCs). Here, only some of the most representative papers are listed as shown in Table 1 [ 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 ].…”

Section: Preclinical Research Of Ed Biotherapymentioning

confidence: 99%

“…For ADSCs-based ED treatment, He et al [ 10 ] showed that injection of extracted ADSCs from the bilateral groin area can repair damaged corpus cavernosum nerves and restore ED to a certain extent, while injections of ADSCs modified by overexpression of VEGF and Smad7 can prevent penile fibrosis, reduce collagen deposition, and improve relaxation properties of smooth muscle cells, thereby restoring erectile function in bilateral cavernous nerve injury (BCNI)-induced ED rats. In addition, Zhang et al [ 11 ] and Cheng et al [ 12 ] also isolated ADSCs from epididymal adipose tissues and human adipose tissues [ 11 13 14 ], and these isolated ADSCs can also restore erectile function in different ED models, such as type 1 diabetic, neurotic, and age-associated ED.…”

Section: Preclinical Research Of Ed Biotherapymentioning

confidence: 99%

Regenerative therapies as a potential treatment of erectile dysfunction

2023

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Erectile dysfunction (ED) is the most common sexual dysfunction disease in adult males. ED can be caused by many factors, such as vascular disease, neuropathy, metabolic disturbances, psychosocial causes, and side effects of medications. Although current oral phosphodiesterase type 5 inhibitors can achieve a certain effect, they cause temporary dilatation of blood vessels with no curative treatment effects. Emerging targeted technologies, such as stem cell therapy, protein therapy, and low-intensity extracorporeal shock wave therapy (Li-ESWT), are being used to achieve more natural and long-lasting effects in treating ED. However, the development and application of these therapeutic methods are still in their infancy, and their pharmacological pathways and specific mechanisms have not been fully discovered. This article reviews the preclinical basic research progress of stem cells, proteins, and Li-ESWT therapy, as well as the current status of clinical application of Li-ESWT therapy.

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