2017
DOI: 10.1016/j.ijantimicag.2017.09.011
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Co-resistance to colistin and tigecycline by disrupting mgrB and ramR with IS insertions in a canine Klebsiella pneumoniae ST37 isolate producing SHV-12, DHA-1 and FosA3

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Cited by 15 publications
(13 citation statements)
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“…Moreover, amikacin has been reported to show a higher rate of microbiologic clearance than polymyxin B or tigecycline (17), which can still be considered for the infections caused by amikacin-susceptible CRKP isolates. A 100% of sensitivity toward tigecycline observed in our study is in accordance with previous study indicating that tigecycline may be considered as the basis of combination treatments for infections caused by such strains although tigecycline-resistant isolates have been reported (18). Tigecycline exhibited high susceptibility towards carbapenem-resistant K. pneumoniae, however, there is still some limitations of tigecycline therapy.…”
Section: Discussionsupporting
confidence: 91%
“…Moreover, amikacin has been reported to show a higher rate of microbiologic clearance than polymyxin B or tigecycline (17), which can still be considered for the infections caused by amikacin-susceptible CRKP isolates. A 100% of sensitivity toward tigecycline observed in our study is in accordance with previous study indicating that tigecycline may be considered as the basis of combination treatments for infections caused by such strains although tigecycline-resistant isolates have been reported (18). Tigecycline exhibited high susceptibility towards carbapenem-resistant K. pneumoniae, however, there is still some limitations of tigecycline therapy.…”
Section: Discussionsupporting
confidence: 91%
“…This sequence type has been previously reported by several other studies as a common ST among CRKP with human origin [11, 25, 26] indicating the successful circulation of this hypervirulent CRKP among the human and animal sources. One CRKP isolate obtained from turkey was characterized with sequence type 37 which has been frequently reported from CRKP of animal origin and is found to be associated with resistance to the last-hope anti-XDR-GNB antibiotics, colistin and tigecycline [27, 28]. In a search to unravel the colistin resistant mechanisms, we found that resistance in the studied CRKP isolates was not related to plasmid-encoded colistin resistance genes mcr - 1 to mcr - 4 .…”
Section: Discussionmentioning
confidence: 99%
“…Our analysis revealed fosA3 in 2 E. coli isolates, and armA in a bla DHA-1 -harboring K. pneumoniae ST15 isolate for the first time in Japan. In addition, both fosA3 and armA were detected in a bla DHA-1 -and bla SHV-12 -harboring K. pneumoniae ST37 isolate, which also showed resistance to colistin and tigecycline by disrupting mgrB and ramR with IS10R insertions (Taniguchi et al, 2017). The detection frequency of those resistance genes was low, but their transmission between companion animals and humans could become a significant future public health concern.…”
Section: Phylogroupmentioning
confidence: 99%