Co-treatment with nitroglycerin and metformin exhibits physicochemically and pathohistologically detectable anticancer effects on fibrosarcoma in hamsters

Popović, K; Popović, Dušica J.; Miljković, Dejan; Popović, Jovan; Lalošević, Dušan; Čapo, Ivan

doi:10.1016/j.biopha.2020.110510

Cited by 4 publications

(2 citation statements)

References 68 publications

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“…The combination of NTG and metformin significantly inhibited fibrosarcoma cell growth without toxicity, compared to monotherapy or control. This antitumor effect is also associated with the inhibition of tumor vasculature, the increase of apoptosis, the inhibition of glucose metabolism and the inhibition of NO metabolism [ 86 ].…”

Section: Preclinical Studies For the Combination Of Antitumor Therapi...mentioning

confidence: 99%

Nitroglycerin: a comprehensive review in cancer therapy

et al. 2023

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Nitroglycerin (NTG) is a prodrug that has long been used in clinical practice for the treatment of angina pectoris. The biotransformation of NTG and subsequent release of nitric oxide (NO) is responsible for its vasodilatating property. Because of the remarkable ambivalence of NO in cancer disease, either protumorigenic or antitumorigenic (partly dependent on low or high concentrations), harnessing the therapeutic potential of NTG has gain interest to improve standard therapies in oncology. Cancer therapeutic resistance remains the greatest challenge to overcome in order to improve the management of cancer patients. As a NO releasing agent, NTG has been the subject of several preclinical and clinical studies used in combinatorial anticancer therapy. Here, we provide an overview of the use of NTG in cancer therapy in order to foresee new potential therapeutic avenues.

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Section: Preclinical Studies For the Combination Of Antitumor Therapi...mentioning

confidence: 99%

Nitroglycerin: a comprehensive review in cancer therapy

et al. 2023

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“…An interesting study by Popovic et al [81] was conceived to investigate the combination of caffeine and metformin (21). Despite not being an anticancer drug, metformin exhibits various antitumor effects, which could be potentiated by the combination with other drugs or natural compounds.…”

Section: Inhibition Of Cell Proliferation and Induction Of Ros-depend...mentioning

confidence: 99%

Synergistic Effects of Caffeine in Combination with Conventional Drugs: Perspectives of a Drug That Never Ages

et al. 2023

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Plants have been known since ancient times for their healing properties, being used as preparations against human diseases of different etiologies. More recently, natural products have been studied and characterized, isolating the phytochemicals responsible for their bioactivity. Most certainly, there are currently numerous active compounds extracted from plants and used as drugs, dietary supplements, or sources of bioactive molecules that are useful in modern drug discovery. Furthermore, phytotherapeutics can modulate the clinical effects of co-administered conventional drugs. In the last few decades, the interest has increased even more in studying the positive synergistic effects between plant-derived bioactives and conventional drugs. Indeed, synergism is a process where multiple compounds act together to exert a merged effect that is greater than that of each of them summed together. The synergistic effects between phytotherapeutics and conventional drugs have been described in different therapeutic areas, and many drugs are based on synergistic interactions with plant derivatives. Among them, caffeine has shown positive synergistic effects with different conventional drugs. Indeed, in addition to their multiple pharmacological activities, a growing body of evidence highlights the synergistic effects of caffeine with different conventional drugs in various therapeutic fields. This review aims to provide an overview of the synergistic therapeutic effects of caffeine and conventional drugs, summarizing the progress reported to date.

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Disulfiram and metformin combination anticancer effect reversible partly by antioxidant nitroglycerin and completely by NF-κB activator mebendazole in hamster fibrosarcoma

Popović

Miljković

et al. 2021

Biomedicine & Pharmacotherapy

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Co-treatment with nitroglycerin and metformin exhibits physicochemically and pathohistologically detectable anticancer effects on fibrosarcoma in hamsters

Cited by 4 publications

References 68 publications

Nitroglycerin: a comprehensive review in cancer therapy

Nitroglycerin: a comprehensive review in cancer therapy

Synergistic Effects of Caffeine in Combination with Conventional Drugs: Perspectives of a Drug That Never Ages

Disulfiram and metformin combination anticancer effect reversible partly by antioxidant nitroglycerin and completely by NF-κB activator mebendazole in hamster fibrosarcoma

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