Co-valorization of corn cobs and dairy wastewater for simultaneous saccharification and lactic acid production: Process optimization and kinetic assessment

David, Anthea Naomi; Sewsynker-Sukai, Yeshona; Kana, E.B. Gueguim

doi:10.1016/j.biortech.2022.126815

Cited by 11 publications

(7 citation statements)

References 42 publications

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“…As can be seen from the figure, the optimum conditions for lactic acid production are pH = 6.5 and temperature of 30 L. plantarum is a mesophilic bacterium, capable of growing at temperatures betwe 10 and 40 °C. In support of our findings, other researchers also cultivated L. plantarum 30 °C as an optimal temperature [31][32][33][34][35], but there are enough investigations in which t strain was cultivated at 37 °C-see for example [5,6,9].…”

Section: Influence Of Ph and Temperaturesupporting

confidence: 86%

“…It is generally accepted that lactic acid production is a growth-associated proce During the fermentation, due to the lactic acid accumulation, the pH value of the bro decreases to about 3.0-3.5 in pH uncontrolled mode [36,37]. Many authors assumed th L. plantarum is a mesophilic bacterium, capable of growing at temperatures between 10 and 40 • C. In support of our findings, other researchers also cultivated L. plantarum at 30 • C as an optimal temperature [31][32][33][34][35], but there are enough investigations in which the strain was cultivated at 37 • C-see for example [5,6,9]. L. plantarum possesses high acidity tolerance and can grow in pH values between 4 and 7.…”

Section: Influence Of Ph and Temperaturesupporting

confidence: 84%

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Lactic Acid Production by Lactiplantibacillus plantarum AC 11S—Kinetics and Modeling

Popova-Krumova,

Danova,

Atanasova

et al. 2024

Microorganisms

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Lactic acid is a versatile chemical with wide application in many industries. It can be produced by the fermentation of different sugars by various lactobacilli and investigations on lactic acid production from different substrates and by different strains are still in progress. The present study aimed to study lactic acid production from lactose by Lactiplantibacillus plantarum AC 11S and to choose a mathematical model describing in the best way the experimental data obtained. The influence of initial substrate concentration was investigated, and optimal pH and temperature were determined. An unstructured mathematical model was developed comprising equations for bacterial growth, substrate consumption, and product formation. The model was solved with different terms for specific growth rates considering substrate and/or product inhibition. The best bacterial growth and lactic acid production were achieved at pH = 6.5 and 30 °C. Production of lactic acid was mainly growth-associated, and at initial substrate concentration over 15 g/L, a considerable product inhibition was observed. The parameters of different models were determined and compared. The modified Gompertz equation gave the best fit when solving only the equation for biomass growth at different initial substrate concentrations. Solving the entire set of differential equations for bacterial growth, substrate consumption, and product formation, the best results were obtained when using a variant of the logistic equation for biomass growth. This variant included a term for product inhibition and described in the best way all experimental data. Solving the model for different biomass concentrations showed that an increase in biomass led to a shorter lag phase and the stationary phase was reached faster. The results obtained, optimum conditions and the kinetic model, are good bases for studying pH-controlled fermentation, as well as a continuous process.

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Section: Influence Of Ph and Temperaturesupporting

confidence: 86%

Section: Influence Of Ph and Temperaturesupporting

confidence: 84%

Lactic Acid Production by Lactiplantibacillus plantarum AC 11S—Kinetics and Modeling

Popova-Krumova,

Danova,

Atanasova

et al. 2024

Microorganisms

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“…As a facultative heterofermentative LAB, La. plantarum can produce 2 mol-LA/mol-glucose through EMP pathway [ 3 , 27 ], and so TSKKU P-8 was considered a potential strain for high-level LA production from glucose derived from SB. On the other hand, CHKKU N-6 grew well on both glucose and xylose.…”

Section: Resultsmentioning

confidence: 99%

Efficient production of lactic acid from cellulose and xylan in sugarcane bagasse by newly isolated Lactiplantibacillus plantarum and Levilactobacillus brevis through simultaneous saccharification and co-fermentation process

Haokok,

Lunprom,

Reungsang

et al. 2023

Heliyon

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“…In addition, it is less computationally expensive to perform the dynamic simulations on enzyme-constrained models than on fine-grained models, such as ME-models (65,66) that explicitly formulate gene expression processes (67,25). Therefore, we expect extensive applications of MORP and dMORP with the development of enzyme-constrained models (68).…”

Section: Discussionmentioning

confidence: 99%

Minimization of proteome reallocation explains metabolic transition in hierarchical utilization of carbon sources

Liu,

Chen,

et al. 2024

Preprint

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Cells choose between alternative pathways in metabolic networks under diverse environmental conditions, but the principles governing the choice are insufficiently understood, especially in response to dynamically changing conditions. Here we observed that a lactic acid bacterium Bacillus coagulans displayed homolactic fermentation on glucose or trehalose as the sole carbon source, but transitioned from homolactic to heterolactic fermentation during the hierarchical utilization of glucose and trehalose when growing on the mixture. We simulated the observation by dynamic minimization of reallocation of proteome (dMORP) using an enzyme-constrained genome-scale metabolic model of B. coagulans, which coincided with our multi-omics data. Moreover, we evolved strains to co-utilize mixed carbon sources, circumventing the hierarchical utilization and inactivating the choice of heterolactic fermentation. Altogether, the findings suggest that upon rapid environmental changes bacteria tend to minimize proteome reallocation and accordingly adjust metabolism, and dMORP would be useful in simulating and understanding cellular dynamics.

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Co-valorization of corn cobs and dairy wastewater for simultaneous saccharification and lactic acid production: Process optimization and kinetic assessment

Cited by 11 publications

References 42 publications

Lactic Acid Production by Lactiplantibacillus plantarum AC 11S—Kinetics and Modeling

Lactic Acid Production by Lactiplantibacillus plantarum AC 11S—Kinetics and Modeling

Efficient production of lactic acid from cellulose and xylan in sugarcane bagasse by newly isolated Lactiplantibacillus plantarum and Levilactobacillus brevis through simultaneous saccharification and co-fermentation process

Minimization of proteome reallocation explains metabolic transition in hierarchical utilization of carbon sources

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