CO2 laser photoacoustic spectrometer for measuring ethylene, acetone, and ammonia in the breath of patients with renal disease

Mitrayana, -; Nikita, Jeilen Gabriela; Wasono, M.A.J.; Satriawan, Mirza

doi:10.1016/j.sbsr.2020.100387

Cited by 8 publications

(4 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Reproduced with permission. [ 85 ] Copyright 2020, Elsevier. c) (v) Fabricated multipass cell for methane detection with mirror B in inset; (vi) 10 ppm methane detection under nitrogen ambient with rise and fall time of the detector.…”

Section: Applications Of Ir Breath Analysis Over Biomarkersmentioning

confidence: 99%

“…With these results, the authors argued that acetone and ethylene can also be an effective biomarkers for renal disease in addition to ammonia (Figure 4b). [ 85 ] Minimum detection limit of 0.23 ppm for detection of ammonia has been explored with InGaAs photodetector and DFB laser and demonstrated 1 s response time. [ 133 ] TDLAS detector with DFB laser at 1.51 µm has been demonstrated with effective ammonia detection limit of 0.16 ppm and response time of 184 s. [ 134 ] However, TDLAS with QCL at 10.3 µm has been demonstrated with the minimum detection limit of 8.3 and 30 ppb at 30 and 1 s response time respectively.…”

Section: Applications Of Ir Breath Analysis Over Biomarkersmentioning

confidence: 99%

“…b) (iii) Photoacoustic-based resonance curve of breath ammonia gas at line 10R14; (iv) Curves for the normalized PA signal versus ethylene, acetone, and ammonia concentration at 10P14, 10P20, and 10R14 lines, respectively. Reproduced with permission [85]. Copyright 2020, Elsevier.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Infrared Non‐Invasive Exhaled Biomarker Sensing: A Review

Ranu,

Rahman

et al. 2023

Advanced Sensor Research

View full text Add to dashboard Cite

Exhaled breath analysis is considered an effective tool for diagnosing the patient's metabolic status because of its non‐invasive nature. Gas chromatography‐mass spectrometry (GC‐MS) and other mass spectrometry techniques are widely used for exhaled breath analysis. Nevertheless, the requirement of a handheld device for real‐time analysis and rapid processing time of multiple samples leads to advancing infrared (IR) based breath gas sensing techniques. Herein, the IR gas sensing technologies are discussed with a focus on non‐dispersive infrared (NDIR), photoacoustic (PAS), and tunable diode laser absorption spectroscopy (TDLAS) gas sensing technologies because of their highly selective gas detection among compound gases (mixture of VOCs), as well as their corresponding sensing mechanisms and characteristics, for real‐time monitoring of exhaled biomarkers. Carbon dioxide, acetone, ammonia, nitric oxide, methane, and ethylene are the significant biomarkers elaborated in this work with their respective clinical applications and the significance of non‐invasive real‐time monitoring using IR detectors. Challenges in selectivity and clinical trials leads to focus on this review. Current market analysis, present status of different techniques to detect specific biomarkers and other challenges with their possible solutions discussed in this review aid in developing highly selective IR‐based handheld breath VOC analyzers for early diagnosis and screening.

show abstract

Section: Applications Of Ir Breath Analysis Over Biomarkersmentioning

confidence: 99%

Section: Applications Of Ir Breath Analysis Over Biomarkersmentioning

confidence: 99%

See 1 more Smart Citation

Infrared Non‐Invasive Exhaled Biomarker Sensing: A Review

Ranu,

Rahman

et al. 2023

Advanced Sensor Research

View full text Add to dashboard Cite

show abstract

“…Nonetheless, research is still underway to address the problem of high working temperatures and to pursue a lower detection limit. On the other hand, NH 3 sensors based on optical methods mainly include gas sensors based on laser absorption spectroscopy, − gas sensors based on photoacoustic spectroscopy, gas sensors based on quartz tuning fork laser spectroscopy, gas sensors based on Fourier transform infrared spectroscopy (FTIR), and gas sensors based on ultraviolet absorption spectroscopy. − Among them, laser absorption spectroscopy-based sensors have been used for the detection of ultratrace gases due to their advantages of damage-free sample and rapid response time. However, it is challenging to avoid the interference caused by other components in EB and to further improve the measurement accuracy in the exhaled breath environment because the components of EB are complex and the concentration of breath NH 3 reaches the ppb level.…”

mentioning

confidence: 99%

Ppb-Level Ammonia Sensor for Exhaled Breath Diagnosis Based on UV-DOAS Combined with Spectral Reconstruction Fitting Neural Network

Zhu,

Zhou,

Tian

et al. 2024

ACS Sens.

View full text Add to dashboard Cite

Ammonia (NH 3 ) in exhaled breath (EB) has been a biomarker for kidney function, and accurate measurement of NH 3 is essential for early screening of kidney disease. In this work, we report an optical sensor that combines ultraviolet differential optical absorption spectroscopy (UV-DOAS) and spectral reconstruction fitting neural network (SRFNN) for detecting NH 3 in EB. UV-DOAS is introduced to eliminate interference from slow change absorption in the EB spectrum while spectral reconstruction fitting is proposed for the first time to map the original spectra onto the sine function spectra by the principle of least absolute deviations. The sine function spectra are then fitted by the least-squares method to eliminate noise signals and the interference of exhaled nitric oxide. Finally, the neural network is built to enable the detection of NH 3 in EB at parts per billion (ppb) level. The laboratory results show that the detection range is 9.50−12425.82 ppb, the mean absolute percentage error (MAPE) is 0.83%, and the detection accuracy is 0.42%. Experimental results prove that the sensor can detect breath NH 3 and identify EB in simulated patients and healthy people. Our sensor will serve as a new and effective system for detecting breath NH 3 with high accuracy and stability in the medical field.

show abstract

Influence of the Spectral Linewidths of a СО2 Laser on the Error in Measuring Gas Concentrations on the Example of Ammonia

Voitsekhovskaya

Shefer

2021

Russ Phys J

View full text Add to dashboard Cite

CO2 laser photoacoustic spectrometer for measuring ethylene, acetone, and ammonia in the breath of patients with renal disease

Cited by 8 publications

References 28 publications

Infrared Non‐Invasive Exhaled Biomarker Sensing: A Review

Infrared Non‐Invasive Exhaled Biomarker Sensing: A Review

Ppb-Level Ammonia Sensor for Exhaled Breath Diagnosis Based on UV-DOAS Combined with Spectral Reconstruction Fitting Neural Network

Influence of the Spectral Linewidths of a СО2 Laser on the Error in Measuring Gas Concentrations on the Example of Ammonia

Contact Info

Product

Resources

About