Coacervação complexa: uma técnica para a encapsulação de probióticos

Silva, Thaiane Marques da; Rodrigues, Luiza Zancan; Codevilla, Cristiane Franco; Silva, Cristiane de Bona da; Menezes, Cristiano Ragagnin de

doi:10.5902/2179460x19714

Cited by 4 publications

References 7 publications

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Metformin hydrochloride sustained release biopolymeric system composed by PLLA‐CMC microparticles

Silva

Nogueira

2021

J of Applied Polymer Sci

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Metformin hydrochloride (MetHCl) is a drug extensively used to treat diabetes mellitus Type 2. However, its high hydrophilicity drastically reduces its metabolic absorption. Consequently, high drug concentrations should be taken by patients to achieve the desired therapeutical efficiency, causing several side effects. The present study proposes the development of a MetHCl sustained release biopolymeric system composed of poly(L-lactic acid) (PLLA) and carboxymethyl cellulose (CMC) as a strategy to minimize the problems aforementioned. The PLLA-CMC microparticles were produced by the double emulsion-solvent evaporation technique using two distinct emulsifiers in the first emulsion (Span 80 and Tween 80). The microparticles were characterized by ultraviolet-visible spectrophotometry, scanning electron microscopy with field emission gun, thermogravimetric analyses, and differential scanning calorimetry (DSC). Additionally, in vitro drug release assays were performed. The results demonstrated that the emulsion stability and encapsulation efficiency increased in a dependent fashion way with the CMC concentration. DSC findings showed that the choice of the emulsifier of the first emulsion influences the polymer particle's crystallinity and, consequently, the releasing behavior of the drug. The in vitro studies revealed that the encapsulation of MetHCl in PLLA-CMC microparticles is a promising sustained release system compatible with a zero-order kinetic mechanism.

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Metformin hydrochloride sustained release biopolymeric system composed by PLLA‐CMC microparticles

Silva

Nogueira

2021

J of Applied Polymer Sci

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Encapsulación de probióticos para aplicaciones alimenticias

R.¹,

G.²,

B.³

2016

biosalud

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Los alimentos funcionales contienen componentes activos que con un consumo habitual favorecen la salud de consumidor. Dentro del concepto de funcional se encuentran los alimentos con microorganismos probióticos, los cuales al ser ingeridos en dosis adecuadas confieren diversos beneficios, estos microorganismos son sensibles a factores tecnológicos y ambientales que pueden reducir su viabilidad, estabilidad y su capacidad funcional. Existen tecnologías como la encapsulación, las cuales permiten mejorar la estabilidad de los probióticos al protegerlos mediante un material de recubrimiento. En este trabajo se realizó una búsqueda sistemática en diversas bases de datos sobre los probióticos más empleados en la industria de alimentos, su capacidad catalítica en matrices alimenticias, métodos de encapsulación, tipos de matrices en la encapsulación, estabilidad bajo condiciones gastrointestinales y los mecanismos de liberación. Se encontró que la encapsulación, además de favorecer la estabilidad de los microorganismos probióticos frente a factores adversos, condiciona según sus características, su aplicación e incorporación en matrices alimenticias de diversas cualidades.

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Lactobacillus fermentum (MTCC-5898) based fermented whey renders prophylactic action against colitis by strengthening the gut barrier function and maintaining immune homeostasis

Kaur

Gupta

Kapila

et al. 2022

Preprint

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Nutritional intervention using probiotic fermented dairy product has emerged as a promising therapeutic strategy to curb inflammatory bowel diseases. The present study was aimed to investigate the prophylactic capability of probiotic Lactobacillus fermentum (LF:MTCC-5898) fermented whey on impaired barrier function in DSS induced mice. Probiotic fermented whey (PFW) consumption improved the symptoms of colitis-associated with intestinal inflammation by significantly (p < 0.01) diminishing the percent loss in body weight, disease activity index and spleen index with improvement in colon length and weight besides hematological and histopathological score. Likewise, pre-treatment with PFW improved the barrier integrity (p < 0.01) in contrast to leaky condition induced by DSS administration characterized with increased permeability of FITC-dextran (451 ± 225.1) across epithelium. PFW consumption also provided the gut immune protection that occurred via significant increase (p < 0.05) in TLR-2 expression and stimulated T-regulatory response by producing TGF-β (p < 0.01), to potently suppress (p < 0.01) induced inflammatory response markers (TNF-α, IL-4 and C-reactive protein). Consistently, in preventive way, PFW intake significantly enhanced (p < 0.05) immunoglobulin (sIgA) secretion and concomitantly restored the Occludin, ZO-1 (p < 0.01), Claudin-1(p < 0.05) transcriptional expression as compared to colitis mice. Additionally, immune-fluorescence further established the presence of intact actin cytoskeleton and tight junction proteins (claudin-1, occludin and ZO-1) after PFW consumption. Thus, PFW rectified the impaired and leaky barrier junctions not only through modulation of transcriptional expression of tight junction genes but also with reduced secretion of inflammatory mediators and helped in ameliorating the colitis. Hence, probiotic fermented whey could be used as potential prophylactic functional food in the prevention of gut ailments.

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Coacervação complexa: uma técnica para a encapsulação de probióticos

Cited by 4 publications

References 7 publications

Metformin hydrochloride sustained release biopolymeric system composed by PLLA‐CMC microparticles

Metformin hydrochloride sustained release biopolymeric system composed by PLLA‐CMC microparticles

Encapsulación de probióticos para aplicaciones alimenticias

Lactobacillus fermentum (MTCC-5898) based fermented whey renders prophylactic action against colitis by strengthening the gut barrier function and maintaining immune homeostasis

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