Coadministration of an Adhesive Conductive Hydrogel Patch and an Injectable Hydrogel to Treat Myocardial Infarction

Wu, Tengling; Cui, Chunyan; Huang, Yuting; Liu, Yang; Fan, Chuanchuan; Han, Xing; Yang, Yang; Xu, Ziyang; Liu, Bo; Fan, Guanwei; Liu, Wenguang

doi:10.1021/acsami.9b17907

Cited by 164 publications

(143 citation statements)

References 54 publications

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“…After 20 repeated adhering and peeling cycles on metals, the PAM-r-MVIC-2 kept a good adhesion with the adhesive strength only decreasing from 40 to 30 kPa ( Figure 5(e) ). Excessive adhesion leads to substrate damage, or the lack of adhesive force leads to easily falling off, which are major obstacles to the applications of self-adhesive hydrogels in ionic skins [ 35 , 36 ]. For the sake of this, the PAM-r-MVIC-2 was examined by adherence to pigskin.…”

Section: Resultsmentioning

confidence: 99%

Dense Hydrogen-Bonding Network Boosts Ionic Conductive Hydrogels with Extremely High Toughness, Rapid Self-Recovery, and Autonomous Adhesion for Human-Motion Detection

Zhang

Wan

et al. 2021

Research

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The construction of ionic conductive hydrogels with high transparency, excellent mechanical robustness, high toughness, and rapid self-recovery is highly desired yet challenging. Herein, a hydrogen-bonding network densification strategy is presented for preparing a highly stretchable and transparent poly(ionic liquid) hydrogel (PAM-r-MVIC) from the perspective of random copolymerization of 1-methyl-3-(4-vinylbenzyl) imidazolium chloride and acrylamide in water. Ascribing to the formation of a dense hydrogen-bonding network, the resultant PAM-r-MVIC exhibited an intrinsically high stretchability (>1000%) and compressibility (90%), fast self-recovery with high toughness (2950 kJ m-3), and excellent fatigue resistance with no deviation for 100 cycles. Dissipative particle dynamics simulations revealed that the orientation of hydrogen bonds along the stretching direction boosted mechanical strength and toughness, which were further proved by the restriction of molecular chain movements ascribing to the formation of a dense hydrogen-bonding network from mean square displacement calculations. Combining with high ionic conductivity over a wide temperature range and autonomous adhesion on various surfaces with tailored adhesive strength, the PAM-r-MVIC can readily work as a highly stretchable and healable ionic conductor for a capacitive/resistive bimodal sensor with self-adhesion, high sensitivity, excellent linearity, and great durability. This study might provide a new path of designing and fabricating ionic conductive hydrogels with high mechanical elasticity, high toughness, and excellent fatigue resilience for skin-inspired ionic sensors in detecting complex human motions.

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Section: Resultsmentioning

confidence: 99%

Dense Hydrogen-Bonding Network Boosts Ionic Conductive Hydrogels with Extremely High Toughness, Rapid Self-Recovery, and Autonomous Adhesion for Human-Motion Detection

Zhang

Wan

et al. 2021

Research

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“…It was confirmed to be able to adhere to porcine myocardium and decreased infarct sizes. 60 Corresponding results of reducing ventricle infarction size were also reported by using the PPy/PGA spring. 94 In summary, PPy-containing composites have been utilized in regenerating different electroactive tissues.…”

Section: Cardiac Tissue Engineeringmentioning

confidence: 64%

“…Both conductivity and modulus of the hydrogels increased till the py concentration in the polymerizing solution reached 50 mM. 59 HA and gelatin were also fabricated into conductive adhesive hydrogel with dopamine-modified PPy by Wu et al 60 Polysaccharide such as XG hydrogel was incorporated with PPy through electropolymerization. 61 Enhanced electrical conductivity compared with pure XG hydrogel was confirmed by cyclic voltammetry evaluation, where PPy/XG hydrogel exhibited similar redox peaks as PPy.…”

Section: Conjugation With Natural Materialsmentioning

confidence: 99%

Polypyrrole-Incorporated Conducting Constructs for Tissue Engineering Applications: A Review

Liang

Goh

2020

Bioelectricity

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Conductive polymers have recently attracted interest in biomedical applications because of their excellent intrinsic electrical conductivity and satisfactory biocompatibility. Polypyrrole (PPy) is one of the most popular among these conductive polymers due to its high conductivity under physiological conditions, and it can be chemically modified to allow biomolecules conjugation. PPy has been used in fabricating biocompatible stimulus-responsive scaffolds for tissue engineering applications, especially for repair and regeneration of electroactive tissues, such as the bone, neuron, and heart. This review provides a comprehensive overview of the basic properties and synthesis methods of PPy, as well as a summary of the materials that have been integrated with PPy. These composite scaffolds are comparatively evaluated with regard to their mechanical properties, biocompatibility, and usage in tissue engineering.

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“…This method could help minimize the risks of extensive myocardial injury, thrombotic occlusion, and arrhythmia. Injectable hydrogels have been also increasingly tested as a minimally (or non) invasive delivery approach for cardiac patch systems (187,188). In a clinical study, acellular alginate-based hydrogels were injected in MI patients, demonstrating the preservation of the LV indices and ejection fraction (189).…”

Section: Transplantation Of Hcmp Constructs Hcmp Delivery Methodsmentioning

confidence: 99%

Engineering Human Cardiac Muscle Patch Constructs for Prevention of Post-infarction LV Remodeling

Wang

Serpooshan

Zhang

2021

Front. Cardiovasc. Med.

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Tissue engineering combines principles of engineering and biology to generate living tissue equivalents for drug testing, disease modeling, and regenerative medicine. As techniques for reprogramming human somatic cells into induced pluripotent stem cells (iPSCs) and subsequently differentiating them into cardiomyocytes and other cardiac cells have become increasingly efficient, progress toward the development of engineered human cardiac muscle patch (hCMP) and heart tissue analogs has accelerated. A few pilot clinical studies in patients with post-infarction LV remodeling have been already approved. Conventional methods for hCMP fabrication include suspending cells within scaffolds, consisting of biocompatible materials, or growing two-dimensional sheets that can be stacked to form multilayered constructs. More recently, advanced technologies, such as micropatterning and three-dimensional bioprinting, have enabled fabrication of hCMP architectures at unprecedented spatiotemporal resolution. However, the studies working on various hCMP-based strategies for in vivo tissue repair face several major obstacles, including the inadequate scalability for clinical applications, poor integration and engraftment rate, and the lack of functional vasculature. Here, we review many of the recent advancements and key concerns in cardiac tissue engineering, focusing primarily on the production of hCMPs at clinical/industrial scales that are suitable for administration to patients with myocardial disease. The wide variety of cardiac cell types and sources that are applicable to hCMP biomanufacturing are elaborated. Finally, some of the key challenges remaining in the field and potential future directions to address these obstacles are discussed.

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Coadministration of an Adhesive Conductive Hydrogel Patch and an Injectable Hydrogel to Treat Myocardial Infarction

Cited by 164 publications

References 54 publications

Dense Hydrogen-Bonding Network Boosts Ionic Conductive Hydrogels with Extremely High Toughness, Rapid Self-Recovery, and Autonomous Adhesion for Human-Motion Detection

Dense Hydrogen-Bonding Network Boosts Ionic Conductive Hydrogels with Extremely High Toughness, Rapid Self-Recovery, and Autonomous Adhesion for Human-Motion Detection

Polypyrrole-Incorporated Conducting Constructs for Tissue Engineering Applications: A Review

Engineering Human Cardiac Muscle Patch Constructs for Prevention of Post-infarction LV Remodeling

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