Coagulase-Negative Staphylococcal Meningitis in Adults: Clinical Characteristics and Therapeutic Outcomes

Huang, Chi-Ren; Lu, Cheng-Hsien; Wu, Jiunn-Jong; Chang, Hsueh‐Wen; Chien, Chun-Chih; Lei, Chien-Bang; Chang, Wen-Neng

doi:10.1007/s15010-005-4083-7

Cited by 61 publications

(53 citation statements)

References 20 publications

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“…In this study, S. epidermidis was the most common identified subtype of the implicated CoNS strains of recent years. As shown in this study, these clinical characteristics of meningitis caused by staphylococcal infection are consistent with the findings of other reports representing overall ABM [9,14,24], showing an increasing incidence of staphylococcal meningitis among adult patients with a postneurosurgical state.…”

Section: Discussionsupporting

confidence: 93%

“…Because viridans streptococci and coagulase-negative staphylococci (CoNS) are common contaminants of cultures, the diagnosis of meningitis caused by these two groups of pathogens was defined with more strict criteria [2,8,9]: only if repeated CSF cultures demonstrated positive results or if they were cultured from the tip of an indwelling neurosurgical device. Patients with evidence of concomitant chronic meningitis or encephalitis, not due to bacterial pathogens were excluded from this study.…”

Section: Methodsmentioning

confidence: 99%

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Bacterial Meningitis in Young Adults in Southern Taiwan: Clinical Characteristics and Therapeutic Outcomes

Tsai

Huang

et al. 2006

Infection

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A post-neurosurgical state is an important preceding event for young adults to develop bacterial meningitis. Of the implicated gram-negative pathogens, K. pneumoniae and P. aeruginosa are common; however, there has been an increase in staphylococcal infection in recent years. Therapeutic results of this specific group of patients showed that 20% (13/62) of the patients died, and 50% (31/61) of the patients in this study had neurologic deficits. However, the small case number and possible bias of case selection has limited the analytical conclusions of this study. Further large-scale studies are needed to delineate the clinical characteristics and therapeutic outcomes of bacterial meningitis in this specific group of patients.

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Section: Discussionsupporting

confidence: 93%

Section: Methodsmentioning

confidence: 99%

Bacterial Meningitis in Young Adults in Southern Taiwan: Clinical Characteristics and Therapeutic Outcomes

Tsai

Huang

et al. 2006

Infection

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“…Coagulase-negative staphylococci (CoNS) are involved in infections that require bactericidal treatment, such as indwelling foreign body-related infections, endocarditis, and meningitis (4,10). As CoNS become more resistant to beta-lactams (2), glycopeptides are often considered to be antibiotics of last resort (12).…”

mentioning

confidence: 99%

Tolerance to the Glycopeptides Vancomycin and Teicoplanin in Coagulase-Negative Staphylococci

Bourgeois

Pestel-Caron

Lemeland

et al. 2007

Antimicrob Agents Chemother

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Tolerance to vancomycin and teicoplanin in 90 clinical isolates of coagulase-negative staphylococci (CoNS) was investigated by time-kill curve methodology. Only six strains, belonging to the Staphylococcus lugdunensis species, exhibited tolerance. The seven other S. lugdunensis strains tested displayed weak susceptibility to the bactericidal activity of glycopeptides compared to the other CoNS. These phenomena are of concern, since S. lugdunensis is recognized as one of the most pathogenic CoNS.Coagulase-negative staphylococci (CoNS) are involved in infections that require bactericidal treatment, such as indwelling foreign body-related infections, endocarditis, and meningitis (4, 10). As CoNS become more resistant to beta-lactams (2), glycopeptides are often considered to be antibiotics of last resort (12). Some investigators, however, have reported glycopeptide tolerance for sporadic CoNS (16,23). Antibiotic tolerance describes a particular "type of resistance" in bacteria capable of surviving, but not growing, in the presence of a normally lethal dose of a given bactericidal antibiotic (20, 21). As early screenings for glycopeptide tolerance in CoNS have been performed by the controversial minimal bactericidal concentration (MBC)/MIC determinations (1,14,19,21), the present study was designed to examine vancomycin and teicoplanin tolerance in a collection of clinically significant CoNS by using the killing curve method, which is considered to be the most reliable method according to the Clinical and Laboratory Standards Institute (CLSI) (formerly NCCLS) (14).An initial set of 79 clinically significant isolates of CoNS from 79 individual patients attending the Rouen University Hospital between January 1999 and April 2001 was studied. Strains were identified to the species level with the ID32Staph system (bioMérieux, Marcy l'Etoile, France) and by a gap gene PCR-restriction fragment length polymorphism assay (24). This set reflected the current epidemiology of CoNS (11), with Staphylococcus epidermidis as a very dominant species (n ϭ 66; 84% of the isolates) and with some less frequently encountered species, i.e., S. hominis (n ϭ 4), S. capitis (n ϭ 3), S. lugdunensis

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“…The detection of methicillin-resistant coagulase-negative (MRCoN) organisms, such as S. haemolyticus, S. epidermidis, Staphylococcus hominis, or Staphylococcus sciuri, might also account for false positives. Although generally regarded as apathogenic, such organisms have been increasingly recognized in central nervous system shunt infections, native or prosthetic valve endocarditis, urinary tract infections, and endophthalmitis (30), as well as in bloodstream infections (31,32,33). In our studies of remnant samples, it was not possible to confirm the presence of MRSA by culture, since all viable organisms in the sample were consumed in the extraction process.…”

Section: Discussionmentioning

confidence: 84%

Detection of Methicillin-Resistant Staphylococcus aureus by a Duplex Droplet Digital PCR Assay

et al. 2013

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bHealth care-associated infections with methicillin-resistant Staphylococcus aureus (MRSA) contribute to significant hospitalization costs. We report here a droplet digital PCR (ddPCR) assay, which is a next-generation emulsion-based endpoint PCR assay for high-precision MRSA analysis. Reference cultures of MRSA, methicillin-susceptible S. aureus (MSSA), and confounders were included as controls. Copan swabs were used to sample cultures and collect specimens for analysis from patients at a large teaching hospital. Swab extraction and cell lysis were accomplished using magnetic-driven agitation of silica beads. Quantitative PCR (qPCR) (Roche Light Cycler 480) and ddPCR (Bio-Rad QX100 droplet digital PCR system) assays were used to detect genes for the staphylococcal protein SA0140 (SA) and the methicillin resistance (mecA) gene employing standard TaqMan

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Coagulase-Negative Staphylococcal Meningitis in Adults: Clinical Characteristics and Therapeutic Outcomes

Cited by 61 publications

References 20 publications

Bacterial Meningitis in Young Adults in Southern Taiwan: Clinical Characteristics and Therapeutic Outcomes

Bacterial Meningitis in Young Adults in Southern Taiwan: Clinical Characteristics and Therapeutic Outcomes

Tolerance to the Glycopeptides Vancomycin and Teicoplanin in Coagulase-Negative Staphylococci

Detection of Methicillin-Resistant Staphylococcus aureus by a Duplex Droplet Digital PCR Assay

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