Coagulation Activation and Hyperviscosity in Infection

Richardson, S. G. N.; Matthews, Kerryn; Cruickshank, J.K.; Geddes, A. M.; Stuart, J.

doi:10.1111/j.1365-2141.1979.tb01155.x

Cited by 22 publications

(12 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…44, 45 Fortunately, vaccines against Haemophilus influenzae , type B, Neisseria meningitidis , and Streptococcus pneumonia are now widely available, and we observed only four AIS cases with preceding bacterial meningitis. Minor infections, however, remain common among children, and have been linked to AIS in adults.…”

Section: Discussionmentioning

confidence: 83%

Recent trauma and acute infection as risk factors for childhood arterial ischemic stroke

Hills¹,

Johnston²,

Sidney³

et al. 2012

Annals of Neurology

View full text Add to dashboard Cite

Objective Trauma and acute infection have been associated with stroke in adults, and are prevalent exposures in children. We hypothesized that these environmental factors are independently associated with childhood arterial ischemic stroke (AIS). Methods In a case-control study nested within a cohort of 2.5 million children (≤ 19 years old) enrolled in an integrated health care plan (1993–2007), childhood AIS cases (n=126) were identified from electronic records and confirmed through chart review. Age- and facility-matched controls (n=378) were randomly selected from the cohort. Exposures were determined from review of medical records prior to the stroke diagnosis, or the same date for the paired controls; time windows were defined a priori. Results A medical encounter for head or neck trauma within the prior 12 weeks was an independent risk factor for childhood AIS (odds ratio [OR] 7.5, 95% confidence interval [CI] 2.9, 19.3), present in 12% of cases (1.6% of controls). Median time from trauma to stroke was 0.5 days (interquartile range 0, 2 days); post-hoc redefinition of trauma exposure (prior 1 week) was more strongly associated with AIS: OR 39 (95% CI 5.1, 298). A medical encounter for a minor acute infection (prior 4 weeks) was also an independent risk factor (OR 4.6, 95% CI 2.6, 8.2), present in 33% of cases (13% of controls). No single infection type predominated. Only two cases had exposure to trauma and infection. Interpretation Trauma and acute infection are common independent risk factors for childhood AIS, and may be targets for stroke prevention strategies.

show abstract

Section: Discussionmentioning

confidence: 83%

Recent trauma and acute infection as risk factors for childhood arterial ischemic stroke

Hills¹,

Johnston²,

Sidney³

et al. 2012

Annals of Neurology

View full text Add to dashboard Cite

show abstract

“…Fibrinogen is produced in the liver and belongs to the 'acute phase proteins ' : thus its levels are increased after infections and trauma [103]. Elevation of fibrinogen could therefore merely represent an acute phase response.…”

Section: Discussionmentioning

confidence: 99%

Plasma fibrinogen — an independent cardiovascular risk factor

Ernst

1990

Journal of Internal Medicine

187

View full text Add to dashboard Cite

. Apart from being an acute phase reactant, fibrinogen appears to play an important although not widely recognized role in athero‐/thrombogenesis. Arteriosclerotic diseases are associated with elevated levels of plasma fibrinogen. Strategies that lower the cardiovascular risk also lower fibrinogen levels. Virtually all accepted risk factors are associated with hyperfibrinogenaemia, while low risk populations usually have low fibrinogen levels. Epidemiological studies show that fibrinogen is a predictor of arteriosclerotic diseases. Its predictive power seems to be as high as or higher than accepted risk factors. These findings and other circumstantial, as well as experimental, evidence suggest that fibrinogen is a powerful, independent cardiovascular risk factor.

show abstract

“…Cigarette smoking is one suggested linkage, although not supported in the present data. Other pathways may include changes in blood coagulation 34 or the presence of specific infection. 35 Currently married women had a 46% lower risk of stroke, while marital status was not predictive for men.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Ischemic Stroke

Simons

McCallum

Friedlander

et al. 1998

Stroke

199

122

View full text Add to dashboard Cite

Background and Purpose-One in 10 deaths in Australia is due to stroke. The predictors of ischemic stroke have not been well defined, although hypertension, atrial fibrillation, and previous stroke have been consistently reported. We report on 98 months' follow-up in a prospective study of cardiovascular disease in the Australian elderly, the Dubbo Study. Methods-The cohort, first examined in 1988, was composed of 2805 men and women 60 years and older. The prediction of ischemic stroke by potential risk factors was examined in a Cox proportional hazards model, after linkage to hospital and death records. Results-Three hundred six men and women manifested an ischemic stroke event (ICD-9-CM 433 to 437), and 95 subjects suffered a fatal stroke event. In the multivariate model, the significant independent predictors of stroke were advancing age, female sex (48% lower risk), being married (30% lower risk), prior history of stroke (227% higher risk), use of antihypertensive drugs (37% higher risk), belonging to the highest category of blood pressure reading (67% higher risk), presence of atrial fibrillation (58% higher risk), HDL cholesterol (36% lower risk for each 1-mmol/L increment), impaired peak expiratory flow (77% higher risk for tertile I than for tertile III), physical disability (59% higher risk), and depression score (41% higher risk for tertile III than for tertile I). Conclusions-These findings suggest that morbidity and mortality associated with ischemic stroke can be predicted by various clinical indicators, some of which may be amenable to intervention. The matters of impaired peak expiratory flow, depression score, and ischemic stroke require further study. (Stroke. 1998;29:1341-1346.)

show abstract

Coagulation Activation and Hyperviscosity in Infection

Cited by 22 publications

References 33 publications

Recent trauma and acute infection as risk factors for childhood arterial ischemic stroke

Recent trauma and acute infection as risk factors for childhood arterial ischemic stroke

Plasma fibrinogen — an independent cardiovascular risk factor

Risk Factors for Ischemic Stroke

Contact Info

Product

Resources

About