Coagulation and Fibrinogenolysis During Whole-Body Hyperthermia

Klaubert, W.; Eisler, K.; Länge, Jean Dominique; Wilmanns, W.

doi:10.1007/978-3-642-83260-4_30

Cited by 6 publications

(2 citation statements)

References 6 publications

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“…At this temperature, HT may also cause coagulation, especially with perfusion or whole-body HT techniques. This will, in turn, induce hypoxia, thus contributing to tumor radioresistance [ 22 , 51 , 52 , 53 , 54 , 55 , 56 ].…”

Section: Hyperthermiamentioning

confidence: 99%

Magnetic Hyperthermia and Radiation Therapy: Radiobiological Principles and Current Practice †

et al. 2018

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Hyperthermia, though by itself generally non-curative for cancer, can significantly increase the efficacy of radiation therapy, as demonstrated by in vitro, in vivo, and clinical results. Its limited use in the clinic is mainly due to various practical implementation difficulties, the most important being how to adequately heat the tumor, especially deep-seated ones. In this work, we first review the effects of hyperthermia on tissue, the limitations of radiation therapy and the radiobiological rationale for combining the two treatment modalities. Subsequently, we review the theory and evidence for magnetic hyperthermia that is based on magnetic nanoparticles, its advantages compared with other methods of hyperthermia, and how it can be used to overcome the problems associated with traditional techniques of hyperthermia.

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Section: Hyperthermiamentioning

confidence: 99%

Magnetic Hyperthermia and Radiation Therapy: Radiobiological Principles and Current Practice †

et al. 2018

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“…Indeed, families with unstable antithrombin variants display thrombotic events under hyperpyretic situations [8–11]. Additionally, a procoagulant state has been identified and thrombosis reported in normal individuals with general febrile syndromes or heat stroke [12–15]. However, the pathophysiological mechanisms responsible for this procoagulant status are not fully understood.…”

Section: Introductionmentioning

confidence: 99%

In vivo effects of hyperthermia on the functional and conformational characteristics of antithrombin

Hernández-Espinosa

Mota²,

Miñano

et al. 2007

Journal of Thrombosis and Haemostasis

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Summary. Background: High temperatures produce in vitro transitions of antithrombin to its inactive latent and polymeric forms. Accordingly, high body temperatures might contribute in vivo to conformational changes in antithrombin associated with increased thrombotic risk. Methods: We assessed the in vivo effects of different hyperthermic stimuli on antithrombin. We studied two mouse models of hyperthermia. (i) Febrile syndrome induced by turpentine. (ii) Heat stroke generated by exposure to 42°C. Body temperatures were measured. Antigen, anti-factor Xa activity and conformational features of plasma antithrombin were studied. Furthermore, structural and ultrastructural features from livers were analyzed. Intracellular retention of serpins (antithrombin and a1-antitrypsin) was studied by western-blotting, immunohistochemistry, and immunogold-labeling-electron microscopy. Results: Hyperthermic stimuli caused a moderate deficiency of circulating antithrombin and a slight increase in its latent form. Moreover, hyperthermia caused intracellular retention of antithrombin into aggregates within the lumen of the endoplasmic reticulum of hepatocytes. This effect was similar for a1-antitrypsin. Conclusion: Hyperthermia causes minor conformational changes on circulating antithrombin in vivo, although it has severe consequences for intracellular antithrombin and other hepatic serpins, inducing the intracellular retention of the nascent protein. These effects may contribute to the moderate plasma deficiency of antithrombin and the increased thrombotic risk detected in hyperthermic conditions.

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Clinical Practice of Whole-Body Hyperthermia: New Directions

Bull

1996

Thermoradiotherapy and Thermochemotherapy

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Coagulation and Fibrinogenolysis During Whole-Body Hyperthermia

Cited by 6 publications

References 6 publications

Magnetic Hyperthermia and Radiation Therapy: Radiobiological Principles and Current Practice †

Magnetic Hyperthermia and Radiation Therapy: Radiobiological Principles and Current Practice †

In vivo effects of hyperthermia on the functional and conformational characteristics of antithrombin

Clinical Practice of Whole-Body Hyperthermia: New Directions

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