Coagulation Homeostasis in Liver Disease

Caldwell, Stephen H.; Carlini, Lauren Evers

doi:10.1002/cld.935

Cited by 10 publications

(27 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…36,46 Forty percent of the dogs in our study had an increase in the acute phase protein and fibrinogen, and Increases in total PC activity in 87% of the dogs with GBM was an unexpected finding because decreases, rather than increases, in total PC activity, have been reported in dogs with hepatobiliary disorders. [17][18][19]46 The clinical relevance of these increases is unknown.…”

Section: Discussionmentioning

confidence: 99%

“…Over the last decade, the complex alterations in coagulation that occur in human patients with hepatobiliary disease have been recognized. 17 , 18 , 19 These alterations involve changes in pro‐ and anticoagulants, as well as changes in factors involved in fibrinolysis. The net result is that human patients with liver disease have laboratory and clinical features of both hypo‐ and hypercoagulability.…”

Section: Introductionmentioning

confidence: 99%

“… 20 , 21 , 22 This conclusion is supported by reports of bleeding and thrombotic tendencies in dogs with liver disease and evidence that their coagulation profiles involve changes in pro‐ and anticoagulants and factors controlling fibrinolysis. 1 , 17 , 18 , 19 …”

Section: Introductionmentioning

confidence: 99%

“…[20][21][22] This conclusion is supported by reports of bleeding and thrombotic tendencies in dogs with liver disease and evidence that their coagulation profiles involve changes in pro-and anticoagulants and factors controlling fibrinolysis. 1,[17][18][19] Despite many reported cases of GBM in dogs, little is known about their coagulation status. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] Studies either have not reported on coagulation parameters or provided only limited information, including PCV, platelet count, PT, aPTT, or some combination of these.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Evaluation of coagulation parameters in dogs with gallbladder mucoceles

Pavlick

deLaforcade

Penninck

et al. 2021

Veterinary Internal Medicne

View full text Add to dashboard Cite

Background: Gallbladder mucocele (GBM) is a common biliary disorder in dogs.Limited information is available on the coagulation status of dogs with GBM.Hypothesis/Objectives: To determine patterns of coagulation alterations in dogs with GBM and correlate them with clinicopathologic abnormalities and ultrasonographic findings of disease severity.Animals: Twenty-three dogs with GBM identified on ultrasound examination were prospectively enrolled.Methods: At the time of GBM identification, blood and urine were collected for CBC, serum biochemical panel, urinalysis, prothrombin time, activated partial thromboplastin time (aPTT), factor VIII, protein C (PC), von Willebrand's factor (vWF), antithrombin activity, fibrinogen, D-dimers, and thromboelastrography (TEG). Gallbladder mucoceles were classified into ultrasound types 1 to 5. Medical records were reviewed for clinical presentation, underlying conditions and to determine if systemic inflammatory response syndrome (SIRS) was present.Results: Based on TEG parameters, maximal amplitude, and G, 19/23 (83%) of dogs with GBM had evaluations consistent with hypercoagulability. On plasma-based coagulation testing, dogs with GBM had increased total PC activity (20/23, 87%), fibrinogen (9/23, 39%), platelet count (9/23, 39%), and D-dimers (6/15, 40%) as well as prolongations in aPTT (9/22, 41%) and low vWF activity (5/21, 24%). No correlation was found between TEG G value and any coagulation or clinical pathology variables, ultrasound stage of GBM or disease severity as assessed by the presence of SIRS.Conclusions and Clinical Importance: Dogs with ultrasonographically identified GBM have changes in whole blood kaolin-activated TEG supporting a hypercoagulable state although traditional plasma-based coagulation testing suggests that a complex state of hemostasis exists.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of coagulation parameters in dogs with gallbladder mucoceles

Pavlick

deLaforcade

Penninck

et al. 2021

Veterinary Internal Medicne

View full text Add to dashboard Cite

show abstract

“…However, in some patients with compensated cirrhosis without ascites and morbid obesity, PCLB may be still the method of choice. If the sole indication for TJLB is "coagulopathy" based on INR or low platelet count, the concept of "rebalanced coagulation" needs to be considered [12,13]. In fact, most patients with "presumed coagulopathy" have normal values on more sophisticated coagulation tests, such as rotational thromboelastometry (ROTEM) [14].…”

Section: Dear Editormentioning

confidence: 99%