Coagulopathy and abdominal aortic aneurism

Coagulation, fibrinolysis, and platelet activation in patients undergoing open and endovascular repair of abdominal aortic aneurysm

“…This may lead to consumption of platelets and coagulation factors to such an extent that a subclinical disseminated intravascular coagulation may exist. 26 Thus, the mural thrombus represents a biologically active entity with the ability to trap polymorphonuclear leukocytes, absorb circulating plasma components, and aggregate platelets as well as being implicated as a source of proteolysis and fibrinolytic activity thought to be implicit in AAA progression. 25,27,28 Furthermore, it has been proposed that the abluminal part of the thrombus could play a critical role in the evolution of AAAs through its ability to act as solid catalyst between substrates transported through the thrombus and proteases originating from the arterial wall.…”

Effect of Combined Therapy of Danaparoid Sodium and Tranexamic Acid on Chronic Disseminated Intravascular Coagulation Associated With Abdominal Aortic Aneurysm

“…In patients with DIC, local activation of coagulation results in the systemic depletion of coagulation factors and platelets, 1 and the basic principal for treating DIC is anticoagulation therapy, such as heparin. 7,8,11,12 Cummins et al reported that long-term treatment with LMWH could provide good symptomatic control of chronic DIC associated with AAA, 5 and as far as we could ascertain, there is not a great difference between LMWH and UFH. However, subcutaneous injection was ruled out because of the large purpura at the site of injection and so we needed to use a drug that could be administered as a bolus injection.…”

Activity of thrombin-activatable fibrinolysis inhibitor in the plasma of patients with abdominal aortic aneurysm

“…Haemostatic disorders in patients with AAA are manifested by activation of both the coagulation and fibrinolysis processes. A dominating prothrombotic tendency is found in the plasma of AAA patients, and the place of a degenerative aortic lesion is usually filled with ILT, the thickness of which correlates with the size of AAA [13,14,34]. Under physiological conditions (retained vascular continuity and intact endothelium), a haemostatic system provides free blood flow within the vascular bed.…”