Coalescence of functional gold and monodisperse silver nanoparticles mediated by black &lt;em&gt;Panax ginseng&lt;/em&gt; Meyer root extract

Wang, Dandan; Markus, Josua; Kim, Yeon-Ju; Wang, Chao; Pérez, Zuly Elizabeth Jiménez; Ahn, Sun Geun; Castro-Aceituno, Verónica; Mathiyalagan, Ramya; Yang, Deok Chun

doi:10.2147/ijn.s113692

Cited by 32 publications

(22 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…FTIR spectrum of the as prepared CDs-RUT nanohybrids showed several characteristic peaks of pure RUT in conjunction with CDs, thereby further con rming the drug attachment onto the CD surface. CDs showed the major transmittance peak/bands at 3323 cm − 1 , 2925 cm − 1 , 1596-1700 cm − 1 and 1017 cm − 1 which corresponds to the stretching vibrations of hydroxyl or amine groups, C-H groups, C = O and aromatic C = C bonds, and C-O bonds respectively [41]. Pure RUT showed peaks at 1652 cm − 1 , 1504 cm − 1 and 1358 cm − 1 which could be the characteristic peaks of mixed C = O and C = C bonds, symmetric stretching vibrations of aromatic ring and C-O stretching respectively [13].…”

Section: Discussionmentioning

confidence: 99%

“…depicted that the ginseng derived CDs showed the major peaks/bands at 3323 cm − 1 , 2925 cm − 1 , 1596-1700 cm − 1 and 1017 cm − 1 which corresponds to the O-H/N-H stretching, C-H stretching, C = O or aromatic C = C stretching and C-O stretching respectively[41]. RUT showed several characteristic peaks of O-H stretching, N-H stretching, C = O stretching, aromatic C = C stretching, and C-O stretching.…”

mentioning

confidence: 97%

See 1 more Smart Citation

Synthesis of a novel green carbon dots as a bioimaging agent and a drug delivery system for enhanced antioxidant and antibacterial efficacy

Tejwan¹,

Kundu²,

Sharma³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Now-a-days, synthesis of carbon dots (CDs) from renewable sources has attracted considerable attention due to their wide spread availability, lower cost, higher aqueous solubility and more biocompatibility. Here, we have synthesized water soluble CDs from the root extract of red Korean ginseng via simple microwave irradiation. The CDs were further loaded with a natural flavonoid, rutin, to check its efficacy as a drug delivery system. Result The CDs showed a size distribution between 1–4 nm and excitation-dependent fluorescence emission, and could be used as a bio-imaging agent.The CDs showed a drug loading content of 14% and a sustained drug release behavior at physiological conditions. CDs showed excellent free radical scavenging activity both in cell free systems and intra-cellular conditions. Besides, loading with the drug further improved the intra-cellular radical scavenging activity. The CDs and the nanohybrids also showed very little toxicity upto the concentration of 100 µg/mL in normal kidney epithelial cells. The CDs and the nanohybrids also showed a dose-dependent antibacterial effect against both gram negative as well as gram positive bacteria. Conclusion Our synthesized green CDs can be considered as a promising candidate for the biomedical applications due to its facile synthesis, low cytotoxicity, excellent fluorescent properties and potential as drug delivery systems.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 97%

Synthesis of a novel green carbon dots as a bioimaging agent and a drug delivery system for enhanced antioxidant and antibacterial efficacy

Tejwan¹,

Kundu²,

Sharma³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Hence, the strategy of replacing potentially toxic chemicals with biological polymers such as sericin could seemingly lessen cytotoxicity-related problems. Apoptotic-positive cells could be characterized by their nuclear fragmentation (Wang et al, 2016), chromatin condensation (Lin et al, 2016) and cell shrinkage (Bortner & Cidlowski, 2007). AuNPs were reported to induce apoptosis through ROS generation in previous studies with dose-dependent manner, which could also be linked to cytotoxicity (Wang et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

One‐pot facile synthesis of silk sericin‐capped gold nanoparticles by UVC radiation: Investigation of stability, biocompatibility, and antibacterial activity

Aktürk

Gök

Erdemli

et al. 2019

J Biomedical Materials Res

View full text Add to dashboard Cite

Herein, an easy one‐pot synthesis method for gold nanoparticles (AuNPs), involving only gold salt and sericin extracted from silkworm cocoon in the presence of ultraviolet C (UVC) radiation, was developed. Nanoparticle formation was confirmed by characteristic surface plasmon resonance peaks at 520–540 nm wavelengths, and the influence of silk sericin on enhancing the colloidal stability of AuNPs was confirmed. Transmission electron microscopy examination showed the average size (<10 nm) and size distribution decreased significantly with higher sericin concentration. No antibacterial activity was observed on Gram‐positive Bacillus subtilis or Gram‐negative Escherichia coli for sole AuNPs (0.065–0.26 mg/ml), but the conjugation of AuNPs with streptomycin antibiotic decreased significantly the required minimum inhibitory concentration doses, as also confirmed with agar plating, Scanning Electron Microscopy and Atomic Force Microscopy analyses. Furthermore, sericin‐capped AuNPs showed high cell viabilities (>100%) and no sign of any detectable apoptosis or necrosis in 1‐day incubation. Also, high real‐time cell proliferation results of AuNPs competitive with positive control groups implied excellent in vitro biocompatibility. These results evidenced that sericin enhanced the colloidal stability of AuNPs and the biological activities of sericin‐capped AuNPs reported here could render them suitable nanoscale vehicles for biomedical applications.

show abstract

“…In addition, peaks at 38.1°, 44.1°, 64.4°, and 77.3° for PDDA-Ag/RGO were attributed to the reflections on the (111) (200), (220), and (311) planes of Ag, respectively. Meanwhile, the characteristic peaks at 38.3°, 44.3°, 64.9°, and 77.69° for the bimetallic PDDA-AuAg/RGO were indexed to diffraction peaks of the (111), (200), (220), and (311) lattice planes of Au, respectively, according to Bragg's reflection with no obvious diffraction peaks of silver, indicating that the surfaces of the Ag nanoparticles were replaced with Au, which led to the formation of a core-shell structure [41]. Compared with its counterparts, all of the peaks in the diffraction pattern for PDDA- A TEM elemental mapping analysis (Figure 2A-F) and energy dispersive X-ray (EDX) spectroscopy ( Figure S2) were conducted to verify the components of the PDDA-AuPtAg/RGO composites.…”

Section: Characterization Of Pdda-auptag/rgo Nanocompositesmentioning

confidence: 99%

“…The peak at 10 • disappeared with the formation of the various nanocomposites, thus indicating that GO was reduced to RGO [38]. The diffraction peaks at around 39 for the bimetallic PDDA-AuAg/RGO were indexed to diffraction peaks of the (111), (200), (220), and (311) lattice planes of Au, respectively, according to Bragg's reflection with no obvious diffraction peaks of silver, indicating that the surfaces of the Ag nanoparticles were replaced with Au, which led to the formation of a core-shell structure [41]. Compared with its counterparts, all of the peaks in the diffraction pattern for PDDA-AuPtAg/RGO were broader owing to the superposition of lattice planes, which suggests the formation of a trimetallic alloy composite.…”

Section: Characterization Of Pdda-auptag/rgo Nanocompositesmentioning

confidence: 99%

A Non-Enzymatic Sensor Based on Trimetallic Nanoalloy with Poly (Diallyldimethylammonium Chloride)-Capped Reduced Graphene Oxide for Dynamic Monitoring Hydrogen Peroxide Production by Cancerous Cells

Jiao

Pan

Liu

et al. 2019

Sensors

View full text Add to dashboard Cite

Catching cancer at an early stage is necessary to make it easier to treat and to save people's lives rather than just extending them. Reactive oxygen species (ROS) have sparked a huge interest owing to their vital role in various biological processes, especially in tumorigenesis, thus leading to the potential of ROS as prognostic biomarkers for cancer. Herein, a non-enzymatic biosensor for the dynamic monitoring of intracellular hydrogen peroxide (H 2 O 2 ), the most important ROS, via an effective electrode composed of poly (diallyldimethylammonium chloride) (PDDA)-capped reduced graphene oxide (RGO) nanosheets with high loading trimetallic AuPtAg nanoalloy, is proposed. The designed biosensor was able to measure H 2 O 2 released from different cancerous cells promptly and precisely owing to the impressive conductivity of RGO and PDDA and the excellent synergistic effect of the ternary alloy in boosting the electrocatalytic activity. Built upon the peroxidase-like activity of the nanoalloy, the developed sensor exhibited distinguished electrochemical performance, resulting in a low detection limit of 1.2 nM and a wide linear range from 0.05 µM to 5.5 mM. Our approach offers a significant contribution toward the further elucidation of the role of ROS in carcinogenesis and the effective screening of cancer at an early stage.It has been proven that reactive oxygen species (ROS), including superoxide (O 2− ), hydrogen peroxide (H 2 O 2 ), hydroxyl radicals, and peroxynitrite, are messenger molecules, which can turn various biological processes on and off [6]. Balanced ROS metabolism increases antioxidant ability, thereby establishing a barrier against tumorigenesis [7,8]. However, DNA damage caused by ROS results in genomic instability and altered gene expression, while ROS-mediated signaling pathways also drive cell proliferation and apoptosis suppression, thus promoting tumor formation [9,10]. Among the ROS, H 2 O 2 has sparked huge interest in anticancer therapies as not only is it the main substance in the cellular response to oxidative stress, but it is also able to pass through cell membranes over a relatively long lifetime. In addition, cancer cells have metabolic and signaling aberrations, and thus exhibit an enhanced H 2 O 2 level that differs from that in normal cells [11,12]. Therefore, the measurement of intracellular H 2 O 2 could be of great value in clarifying its role in oncogenesis and exploring advanced therapeutic strategies for cancer and other ROS-related diseases.Although various analytical techniques for measuring H 2 O 2 , such as spectrophotometry and chemiluminescence, have been developed, they still suffer drawbacks such as low detection limits and complex processing when faced with the challenge of achieving detection limits in the nanomolar range in living cells [13,14]. In this regard, electrochemical techniques with high sensitivity and simplicity to improve the timely detection of H 2 O 2 in vivo have gained increasing attention. Enzymes like horseradish peroxidase have been widely us...

show abstract

Coalescence of functional gold and monodisperse silver nanoparticles mediated by black <em>Panax ginseng</em> Meyer root extract

Cited by 32 publications

References 55 publications

Synthesis of a novel green carbon dots as a bioimaging agent and a drug delivery system for enhanced antioxidant and antibacterial efficacy

Synthesis of a novel green carbon dots as a bioimaging agent and a drug delivery system for enhanced antioxidant and antibacterial efficacy

One‐pot facile synthesis of silk sericin‐capped gold nanoparticles by UVC radiation: Investigation of stability, biocompatibility, and antibacterial activity

A Non-Enzymatic Sensor Based on Trimetallic Nanoalloy with Poly (Diallyldimethylammonium Chloride)-Capped Reduced Graphene Oxide for Dynamic Monitoring Hydrogen Peroxide Production by Cancerous Cells

Contact Info

Product

Resources

About