Coassembling functionalized glycopolypeptides to prepare pH-responsive self-indicating nanocomplexes to manipulate self-assembly/drug delivery and visualize intracellular drug release

Self-indicating polymers: a pathway to intelligent materials

“…The ICT process is very fast while the intermolecular charge transfer mechanism is relatively slow. 157,158 Ratiometric probes have been prepared by two main mechanisms of FRET and ICT [136][137][138][139] The ICT-based sensors have a simpler structure, and tuning of the donor-p-acceptor (D/p/A) leads to different optical and fluorescence emission or/ and color changes in typical ICT fluorescence sensors. This characteristic can be used in the probes with a high selectivity and sensitivity for sensing if an analyte causes structural variations.…”

“…Junyang et al synthesized pH-responsive polymeric micelles that are used for intelligent tumor drug delivery. 139 They synthesized glycopolypeptides with hyaluronic acid, modified with tetraphenyl ethylene (TPE), and a pH-sensitive doxorubicin (DOX) prodrug. Coassembling these peptides yielded pH-responsive nanocomplexes with tunable size and morphologies.…”

Aggregation-induced emission-active micelles: synthesis, characterization, and applications

“…Recently, Huang et al first synthesized HA-based glycopolypeptides modified by TPE ( HA-PFLGgTPE ) and a pH-sensitive DOX prodrug ( HA-PFLGgDOX ) (Fig. 20g) 168 through Diels–Alder reaction. Subsequently, the two resulting glycopolypeptides were co-assembled with various formulations to generate pH-responsive nanocomplexes.…”