Coated melt-spun acrylonitrile-based suture for delayed release of nitric oxide

Lowe, Alysia; Deng, Wenjin; Smith, Dennis W.; Balkus, Kenneth J.

doi:10.1016/j.matlet.2014.03.174

Cited by 8 publications

(6 citation statements)

References 9 publications

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“…In order to control the release rate of NO, the melt‐spun monofilaments were dip‐coated with PCL solution. The formed porous structure enabled prolonged NO release from AN/VIM fibres up to 3 days, compared with 3 hr release of uncoated fibres 63 . As mentioned before, NO is effective as an anti‐inflammatory coating.…”

Section: Fabrication Processmentioning

confidence: 70%

“…The suture was coated with PCL. The result showed that melt‐spun sutures had high tensile strength, and PCL coated sutures significantly decreased NO release compared with the uncoated suture, which makes it easier to achieve sustained NO release 63 …”

Section: Classification Of Suture Materialsmentioning

confidence: 99%

“…The melt spinning method was also employed to fabricate an Acrylonitrile‐co‐1‐vinylimidazole (AN/VIM) copolymer that incorporated NO 63 . In order to control the release rate of NO, the melt‐spun monofilaments were dip‐coated with PCL solution.…”

Section: Fabrication Processmentioning

confidence: 99%

“…The gaseous delivery of NO to wound sites is not practical, as it is a diatomic free radical, making it reactive. A way to deliver NO in solid form would be ideal 63 . Solid delivery of NO to tissues is achieved by the incorporation of NO into a suture, which produces a thromboresistant antimicrobial material able to provide enhanced healing to both chronic and acute wounds 23,63 .…”

Section: Classification Of Suture Materialsmentioning

confidence: 99%

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Engineering and polymeric composition of drug‐eluting suture: A review

Deng

Qasim

Ali

2021

J Biomedical Materials Res

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Sutures are the most popular surgical implants in the global surgical equipment market. They are used for holding tissues together to achieve wound closure. However, controlling the body's immune response to these “foreign bodies” at site of infection is challenging. Natural polymers such as collagen, silk, nylon, and cotton, and synthetic polymers such as polycaprolactone, poly(lactic‐co‐glycolic acid), poly(p‐dioxanone) and so forth, contribute the robust foundation for the engineering of drug‐eluting sutures. The incorporation of active pharmaceutical ingredients (APIs) with polymeric composition of suture materials is an efficient way to reduce inflammatory reaction in the wound site as well as to control bacterial growth, while allowing wound healing. The incorporation of polymeric composition in surgical sutures has been found to add high flexibility as well as excellent physical and mechanical properties. Fabrication processes and polymer materials allow control over drug‐eluting profiles to effectively address wound healing requirements. This review outlines and discusses (a) polymer materials and APIs used in suture applications, including absorbable and nonabsorbable sutures; (b) suture structures, such as monofilament, multifilament, barded and smart sutures; and (c) the existing manufacturing techniques for drug‐eluting suture production, including electrospinning, melt‐extrusion and coating.

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Section: Fabrication Processmentioning

confidence: 70%

Section: Classification Of Suture Materialsmentioning

confidence: 99%

Section: Fabrication Processmentioning

confidence: 99%

Section: Classification Of Suture Materialsmentioning

confidence: 99%

See 2 more Smart Citations

Engineering and polymeric composition of drug‐eluting suture: A review

Deng

Qasim

Ali

2021

J Biomedical Materials Res

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“…NO-releasing sutures hold promise in treating injury located in deep tissue. PCL-coated melt-spun acrylonitrilebased sutures could release NO continually (Lowe et al, 2014). NO could be released from the sutures after they were exposed to moist environments.…”

Section: Tunable Release Of No For Wound Healingmentioning

confidence: 99%

Controlled nitric oxide release for tissue repair and regeneration

Nie¹,

2016

Turk J Biol

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The discovery that nitric oxide (NO) plays crucial roles in mammalian systems has spurred considerable interest in its translational application. However, the major problem with its application in clinical settings is the high reactivity of NO, which makes it difficult to supply NO with spatiotemporal accuracy while maintaining its bioactivity. To deliver NO at a specified rate to a preferred location for a precise period of time is highly demanded. The significant technological advancements in controlled release make it possible to control NO release at the target site with a sustained release rate and an optimum concentration, and then provide a longer therapeutic duration of NO. Moreover, biomaterials designed for regenerative applications provide carriers with support structures for controlled NO releasing. Meanwhile, engineered matrices with controlled NO release have been used as vehicles for stem cell delivery to enhance cell engraftment and further to improve therapeutic effects of transplanted cells. In this review, we will provide an overview of controlled NO release materials, as well as the mechanisms of their treatment effects in tissue-repairing processes. Furthermore, the application of on-demand NO-releasing materials as carriers for stem cell transplantation and the NO-based therapeutic applications in translational medicine will be discussed.

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Antimicrobial Surgical Sutures: Fabrication and Application of Infection Prevention and Wound Healing

Wang

Robledo-Lara

et al. 2021

Fibers Polym

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Coated melt-spun acrylonitrile-based suture for delayed release of nitric oxide

Cited by 8 publications

References 9 publications

Engineering and polymeric composition of drug‐eluting suture: A review

Engineering and polymeric composition of drug‐eluting suture: A review

Controlled nitric oxide release for tissue repair and regeneration

Antimicrobial Surgical Sutures: Fabrication and Application of Infection Prevention and Wound Healing

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