Coating of polymers with titanium-based layers by a novel plasma-assisted chemical vapor deposition process

Breme, Frank; Buttstaedt, Johannes; Emig, G.

doi:10.1016/s0040-6090(00)01329-8

Cited by 30 publications

(16 citation statements)

References 3 publications

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“…Bremea et al coated polyethylenetherephthalate (PET), polyethersulfone (PES), polyvinylchloride (PVC), polytetrafluoroethylene (PTFE), polyethylene and polypropylene (PP) on titanium by a novel plasma‐assisted chemical vapor deposition process (PACVD) at very low temperatures (about 60°C). They demonstrated that many kinds of geometries such as tubes or textile structures can be coated and the coating had huge potential to improve the bio‐ and blood compatibility of titanium medical devices 14. Hansson et al reported that poly( L ‐lysine)‐ g ‐poly(ethylene glycol) (PLL‐ g ‐PEG) coated surfaces displayed a prolonged clotting time, ∼2–3 times longer than for uncoated titanium 15.…”

Section: Introductionmentioning

confidence: 99%

“…They demonstrated that many kinds of geometries such as tubes or textile structures can be coated and the coating had huge potential to improve the bioand blood compatibility of titanium medical devices. 14 Hansson et al reported that poly(L-lysine)-gpoly(ethylene glycol) (PLL-g-PEG) coated surfaces displayed a prolonged clotting time, $2-3 times longer than for uncoated titanium. 15 To our knowledge, little has been studied up to now on the possible effects of immobilizing biological molecules on titanium surfaces to enhance blood compatibility.…”

Section: Introductionmentioning

confidence: 99%

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Anticoagulant surface modification of titanium via layer‐by‐layer assembly of collagen and sulfated chitosan multilayers

Huang

Chen

et al. 2008

J Biomedical Materials Res

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Extracellular matrix (ECM)-like biomimetic surface modification of cardiovascular implants is a promising method for improving hemocompatibility. In the present work, collagen (Col) and sulfated chitosan (SCS) multilayers were coated on pure titanium using a layer-by-layer (LBL) self-assembly technique. The Col-SCS multilayer growth was carried out by first depositing a single layer of positively charged poly-L-lysine (PLL) on the NaOH-treated titanium substrate (negatively charged surface), followed by alternate deposition of negatively charged SCS and positively charged Col, and terminated by an outermost layer of SCS. Platelet adhesion in vitro, partial activated thromboplastin time (APTT) and prothrombin time (PT) assays were used to evaluate the hemocompatibility of the Col-SCS multilayer coated titanium. The multilayer processed surfaces displayed reduced platelet adhesion and activation, and prolonged clotting time of APTT and PT compared with untreated titanium. Thus, the approach described here may provide a basis for the preparation of modified titanium surfaces for application in cardiovascular implants.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anticoagulant surface modification of titanium via layer‐by‐layer assembly of collagen and sulfated chitosan multilayers

Huang

Chen

et al. 2008

J Biomedical Materials Res

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“…There are many problems in depositing inorganic films on polymer surfaces by conventional methods. Chemical vapor deposition (CVD) and plasma‐enhanced CVD (PE‐CVD) processing have been reported for polymer surface coating 11–15 . However, typical CVD processes generally operate at temperatures (∼300°–500°C) much higher than the softening and melting temperatures of the polymers (∼125°–250°C).…”

Section: Introductionmentioning

confidence: 99%

Novel Processing to Produce Polymer/Ceramic Nanocomposites by Atomic Layer Deposition

Liu

Hakim

Zhan

et al. 2006

Journal of the American Ceramic Society

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An innovative process to uniformly incorporate dispersed nanoscale ceramic inclusions within a polymer matrix was demonstrated. Micron‐sized high density polyethylene particles were coated with ultrathin alumina films by atomic layer deposition in a fluidized bed reactor at 77°C. The deposition of alumina on the polymer particle surface was confirmed by Fourier transform infrared spectroscopy and X‐ray photoelectron spectroscopy. Conformal coatings of alumina were confirmed by transmission electron microscopy and focused ion beam cross‐sectional scanning electron microscopy. The results of inductively coupled plasma atomic emission spectroscopy suggested that there was a nucleation period. The results of scanning electron microscopy, particle size distribution, and surface area of the uncoated and nanocoated particles showed that there was no aggregation of particles during the coating process. The coated polymer particles were extruded by a heated extruder at controlled temperatures. The successful dispersion of the crushed alumina shells in the polymer matrix following extrusion was confirmed using cross‐sectional transmission electron microscopy. The dispersion of alumina flakes can be controlled by varying the polymer particle size.

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“…To transfer the benefits of titanium‐based surfaces to polymer materials a plasma‐activated chemical vapor deposition (PACVD) process has been developed to coat polymers with titanium based layers 8. First, in vitro tests with human fibroblasts verified the supposed biocompatibility 9. Although considerable knowledge is available on EC growth on polymers, very few studies have concentrated on EC function on polymers, such as coagulation,10, 11 platelet adhesion to endothelium,12 production of tissue factor and PGI 2 ,11 or induction of cellular adhesion molecules 13, 14…”

Section: Introductionmentioning

confidence: 99%

Expression of adhesion molecules and cytokines in vitro by endothelial cells seeded on various polymer surfaces coated with titaniumcarboxonitride

Lehle

Buttstaedt

Birnbaum

2003

J Biomedical Materials Res

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Although endothelial cell (EC) seeding improves the patency of vascular prostheses, the detachment of adherent ECs after the restoration of circulation remains one of the major obstacles. Polymer surfaces for endothelialization can be optimized. In this study, polyethylene terephthalate (PET), polypropylene (PP), polytetrafluoroethylene (PTFE), polyurethane (PUR), and silicone were coated with a titaniumcarboxonitride (Ti(C,N,O)) layer by a plasma-assisted chemical vapor deposition process to verify the effect of titanium onto human saphenous vein ECs. Almost confluent EC monolayers were evaluated for 1) proliferation activity and 2) expression of adhesion molecules using cellular enzyme-linked immunosorbent assay and release of cytokines. The results showed that all titanium-coated polymers and uncoated PET have no toxic effect on human saphenous vein ECs excepting uncoated PTFE, PP, and silicone. Moreover, growing ECs showed an insignificant decrease in cytokine production and an unessential change in basal expression of adhesion molecules. Tumor necrosis factor-alpha-induced response depends on polymer surface: for example, intercellular adhesion molecule-1 expression decreased. E-selectin expression was unchanged for culturing ECs on coated PET, PP, and PTFE and reduced for polyurethane and silicone. Vascular cell adhesion molecule-1 expression was unchanged for coated PUR and silicone and reduced for PET, PP, and PTFE. In summary, titanium-coating layers promote adhesion of human ECs on polymer vascular grafts with no proinflammatory reaction of ECs.

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Coating of polymers with titanium-based layers by a novel plasma-assisted chemical vapor deposition process

Cited by 30 publications

References 3 publications

Anticoagulant surface modification of titanium via layer‐by‐layer assembly of collagen and sulfated chitosan multilayers

Anticoagulant surface modification of titanium via layer‐by‐layer assembly of collagen and sulfated chitosan multilayers

Novel Processing to Produce Polymer/Ceramic Nanocomposites by Atomic Layer Deposition

Expression of adhesion molecules and cytokines in vitro by endothelial cells seeded on various polymer surfaces coated with titaniumcarboxonitride

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