Coaxial 3D printing of hierarchical structured hydrogel scaffolds for on-demand repair of spinal cord injury

Li, Yuxuan; Cheng, Shengnan; Wen, Huilong; Xiao, Longyi; Deng, Zongwu; Huang, Jie; Zhang, Zhijun

doi:10.1016/j.actbio.2023.07.020

Cited by 13 publications

(2 citation statements)

References 40 publications

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“…Therefore, it is very promising to fabricate hydrogels with dual network structures based on high-strength polymers, which can improve the stability of gelatin and expand its application in biomedical fields. 19–21…”

Section: Introductionmentioning

confidence: 99%

The fabrication of stretchable dual network P(HEMA-AM)/gelatin hydrogels as potential delivery carriers

Xu,

Liu,

Wang

et al. 2024

New J. Chem.

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Section: Introductionmentioning

confidence: 99%

The fabrication of stretchable dual network P(HEMA-AM)/gelatin hydrogels as potential delivery carriers

Xu,

Liu,

Wang

et al. 2024

New J. Chem.

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“…Meanwhile, with the development of material forming technique, it has been found that NSC-laden scaffolds own extra superiorities, such as bridging the lesion gap, reducing glial scars, and facilitating axon growth [3,4]. In recent years, hydrogel scaffolds have been intensively researched in SCI repair because they own the feasibility to transport bioactive compounds, peptides, or extracellular vesicles to regulate the microenvironment after SCI [5][6][7][8][9]. Furthermore, compared with polymer scaffolds, hydrogel scaffolds could better mimic the extracellular matrix (ECM), which is beneficial to cell growth and could encapsulate larger number of cells into their dense molecule chain networks [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

3D hydrogel microfibers promote the differentiation of encapsulated neural stem cells and facilitate neuron protection and axon regrowth after complete transactional spinal cord injury

Zhang,

Li,

Guo

et al. 2024

Biofabrication

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Spinal cord injury (SCI) could cause permanent impairment to motor or sensory functions. Pre-cultured neural stem cell (NSC) hydrogel scaffolds were demonstrated to be a promising approach to treat SCI with anti-inflammatory effect, axon regrowth and motor function restore. Here in this study, we performed coaxial extrusion process to fabricate a core-shell hydrogel microfiber with high NSC density in the core portion. Oxidized hyaluronic acid (OHA), carboxymethyl chitosan (CMC) and Matrigel blend was used as matrix for NSC growth and to facilitate the fabrication process. During in vitro differentiation culture, it is found that NSC microfiber could differentiate into neuron and astrocyte with higher efficiency compared with NSC cultured in petri dishes. Furthermore, during in vivo transplantation, NSC microfibers were coated with poly lactic acid (PLA) nanosheet by electrospinning for reinforcement. The coated NSC nanofibers showed higher anti-inflammatory effect and lesion cavity filling rate compared with control group. Meanwhile, more neuron- and oligodendrocyte-like cells were visualized in lesion epicenter. Finally, axon regrowth across the whole lesion site was observed, demonstrating the microfiber could guide renascent axon regrowth. Experiment results indicate that the NSC microfiber is a promising bioactive treatment for complete SCI treatment with better outcomes.

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Crosslinking strategy and promotion role of cellulose as a composite hydrogel component for three-dimensional printing – A review

Mo,

Huang,

Sheng

et al. 2024

Food Hydrocolloids

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Coaxial 3D printing of hierarchical structured hydrogel scaffolds for on-demand repair of spinal cord injury

Cited by 13 publications

References 40 publications

The fabrication of stretchable dual network P(HEMA-AM)/gelatin hydrogels as potential delivery carriers

The fabrication of stretchable dual network P(HEMA-AM)/gelatin hydrogels as potential delivery carriers

3D hydrogel microfibers promote the differentiation of encapsulated neural stem cells and facilitate neuron protection and axon regrowth after complete transactional spinal cord injury

Crosslinking strategy and promotion role of cellulose as a composite hydrogel component for three-dimensional printing – A review

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