Coaxial electrospinning multicomponent functional controlled-release vascular graft: Optimization of graft properties

Yin, Anlin; Luo, Rifang; Li, Jiukai; Mo, Xiumei; Wang, Yunbing; Zhang, Xingdong

doi:10.1016/j.colsurfb.2017.01.045

Cited by 38 publications

(28 citation statements)

References 25 publications

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“…Good mechanical properties of a scaffold are helpful for successful cell transplantation (36). In the present study, it was observed that BM c-kit + cells exhibited improved proliferation on SF/P(LLA-CL) and P(LLA-CL) electrospun sheets compared with the c-kit + only group.…”

Section: Discussionmentioning

confidence: 99%

Silk fibroin/poly(L‑lactic acid‑co‑ε‑caprolactone) electrospun nanofibrous scaffolds exert a protective effect following myocardial infarction

Wang

Xue

et al. 2019

Exp Ther Med

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Electrospinning using biocompatible polymer scaffolds, seeded with or without stem cells, is considered a promising technique for producing fibrous scaffolds with therapeutic possibilities for ischemic heart disease. However, no optimal scaffolds for treating ischemic heart disease have been identified thus far. In the present study, it was evaluated whether electrospun silk fibroin (SF)-blended poly(L-lactic acid-co-ε-caprolactone) [P(LLA-CL)] scaffolds that were seeded with cluster of differentiation 117 (c-kit) + bone marrow (BM) cells may serve a protective role in cardiac remodeling following myocardial infarction (MI). Mechanical characteristics and cytocompatibility were compared between SF/P(LLA-CL) and P(LLA-CL) electrospun nanofibrous scaffolds in vitro . It was observed that MI led to a significant increase of the c-kit + BM cell subpopulation in mice. Magnetic activated cell sorting was performed to harvest the c-kit + cell population from the BM of mice following MI. c-kit + BM cells were seeded on SF/P(LLA-CL) and P(LLA-CL) electrospun nanofibrous scaffolds. Results indicated that SF/P(LLA-CL) electrospun nanofibrous scaffolds were superior to P(LLA-CL) electrospun nanofibrous scaffolds in improving c-kit + BM cell proliferation. Additionally, compared with pure SF/P(LLA-CL) electrospun nanofibrous scaffolds, SF/P(LLA-CL) scaffolds seeded with c-kit + BM cells resulted in lower levels of MI markers and reduced infarct size, leading to greater global heart function improvement in vivo . The findings of the present study indicated that SF/P(LLA-CL) electrospun nanofibrous scaffolds seeded with c-kit + BM cells exert a protective effect against MI and may be a promising approach for cardiac regeneration after ischemic heart disease.

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Section: Discussionmentioning

confidence: 99%

Silk fibroin/poly(L‑lactic acid‑co‑ε‑caprolactone) electrospun nanofibrous scaffolds exert a protective effect following myocardial infarction

Wang

Xue

et al. 2019

Exp Ther Med

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“…2a, it was found that the release behavior of TEMPOL for all the samples experienced two stages: (i) the initial burst release in the first day with a release percentage of 40% to 70%, and (ii) the continuous slow release to a platform for the following 18 days. The initial burst release is mainly attributed to the diffusion of TEMPOL on the surface or under very near the surface of fibers [38]. Comparably, the releasing rates of P-T-0.5 and P-T-1 in 24 h were obvious slower than others; it is assumed that appropriate TEMPOL loading in such electrospun membranes can also preserve a low TEMPOL release rate that are pre-ferable for a long-term scavenge of ROS.…”

Section: In Vitro Release Of Tempolmentioning

confidence: 96%

Enabling topical and long-term anti-radical properties for percutaneous coronary intervention-related complications by incorporating TEMPOL into electrospun nanofibers

Wang

Shen

et al. 2020

Sci. China Mater.

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Scavenging reactive oxygen species (ROS) by antioxidants has been demonstrated as the most effective strategy for preventing percutaneous coronary intervention (PCI)-related complications. However, topical and long-term delivery of ROS antioxidants to a specific vascular tissue is proven to be a great challenge. Herein, an ROS scavenger of 4hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPOL) is incorporated into electrospun nanofibers with a tunable loading amount to achieve its topical applicability and long-term antiradical capability. Biological functions of such TEMPOL-loaded electrospun membranes are evaluated by cell proliferation, ROS-scavenging capability, monocyte adhesion, cell migration, inflammatory molecule secretion and mRNA expression in vitro. After optimizing the loading amount of TEMPOL, such an electrospun membrane presents a superior ROS-scavenging and anti-inflammation performance for both endothelial cells and macrophages. The expression of endothelial prothrombogenic molecules and the migration of vascular smooth muscle cells (VSMCs) are also effectively inhibited. Thus, it is bravely predicted that the topical use of such a TEMPOL-loaded electrospun system will be a promising pathway for the anti-restenosis therapy, especially when used as a novel coating on stent for long-term and topical delivery of antioxidant drugs.

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“…The small-diameter vascular grafts, which are often used in clinics, are becoming challenging for less proper biocompatibility and mechanical properties. Yin et al [50] prepared a vascular stent loaded with heparin by coaxial electrospinning technology, in which the heparin is the core layer, and collagen/chitosan/PLCL is the shell layer. Finally, it was found that the tensile strength and other properties of the blood vessel have nothing to do with factors such as the concentration of heparin in the core layer.…”

Section: Enhanced By Optimization Of Electrospinning Parametersmentioning

confidence: 99%

Progress of Improving Mechanical Strength of Electrospun Nanofibrous Membranes

Han

Zhang

et al. 2020

Macro Materials & Eng

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Electrospun nanofibers with superior performance have attracted widespread attention from researchers due to their extensive application in biomedical materials, filtration, catalysis, and so forth. However, the low mechanical properties, such as elongation at breaking strength and tensile strength, restrict the application of the nanofibers in many aspects. This article describes the recent progress in improving the mechanical properties of electrospun nanofibrous membranes. At present, methods to increase the mechanical strength of nanofibers are mainly based on the introduction of appropriate polymer materials, improvements in spinning parameters, and post-treatment. Herein, the principle, advantages, and disadvantages of those methods in depth are described. Finally, the research on enhancing the mechanical properties of electrospun nanofibrous membranes and their future development is being discussed.

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Coaxial electrospinning multicomponent functional controlled-release vascular graft: Optimization of graft properties

Cited by 38 publications

References 25 publications

Silk fibroin/poly(L‑lactic acid‑co‑ε‑caprolactone) electrospun nanofibrous scaffolds exert a protective effect following myocardial infarction

Silk fibroin/poly(L‑lactic acid‑co‑ε‑caprolactone) electrospun nanofibrous scaffolds exert a protective effect following myocardial infarction

Enabling topical and long-term anti-radical properties for percutaneous coronary intervention-related complications by incorporating TEMPOL into electrospun nanofibers

Progress of Improving Mechanical Strength of Electrospun Nanofibrous Membranes

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