Coaxial electrospun nanofibers as drug delivery system for local treatment of periodontitis

Reise, Markus; Kranz, Stefan; Guellmar, André; Wyrwa, Ralf; Rosenbaum, Tobias; Weisser, Jürgen; Jurke, Aileen; Schnabelrauch, Matthias; Heyder, Markus; Watts, D.C.; Sigusch, Bernd W.

doi:10.1016/j.dental.2022.12.008

Cited by 21 publications

(13 citation statements)

References 27 publications

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“…Reise et al fabricated poly(L-lactide-co-D,L-lactide) fiber mats with different distributions of metronidazole using coaxial and conventional electrospinning techniques [ 83 ]. The coaxially fabricated fibers exhibited improved and sustained drug release compared with conventional fibers and had a higher antibacterial effect and better biocompatibility with human gingival fibroblasts.…”

Section: Fabrication Methodsmentioning

confidence: 99%

“…Multijet electrospinning is a technique that involves the use of multiple needles or nozzles to generate multiple jets of polymer solution or melt [ 83 ]. Multijet electrospinning allows the deposition of multiple fibers of different materials and sizes on the same substrate, thus enabling the fabrication of multilayered structures or composite materials.…”

Section: Fabrication Methodsmentioning

confidence: 99%

“…Coaxial electrospinning [81][82][83] Two or more fluids are spun together in a coaxial arrangement, producing fibers with a core-shell structure Drug delivery, tissue engineering, and energy storage…”

Section: Medical Textiles Filtration and Protective Clothingmentioning

confidence: 99%

“…Multijet electrospinning [83][84][85] Multiple spinning nozzles are used simultaneously to produce a large volume of fibers in a short amount of time Tissue engineering, drug delivery, and energy storage…”

Section: Medical Textiles Filtration and Protective Clothingmentioning

confidence: 99%

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Therapeutic Agent-Loaded Fibrous Scaffolds for Biomedical Applications

et al. 2023

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Tissue engineering is a sophisticated field that involves the integration of various disciplines, such as clinical medicine, material science, and life science, to repair or regenerate damaged tissues and organs. To achieve the successful regeneration of damaged or diseased tissues, it is necessary to fabricate biomimetic scaffolds that provide structural support to the surrounding cells and tissues. Fibrous scaffolds loaded with therapeutic agents have shown considerable potential in tissue engineering. In this comprehensive review, we examine various methods for fabricating bioactive molecule-loaded fibrous scaffolds, including preparation methods for fibrous scaffolds and drug-loading techniques. Additionally, we delved into the recent biomedical applications of these scaffolds, such as tissue regeneration, inhibition of tumor recurrence, and immunomodulation. The aim of this review is to discuss the latest research trends in fibrous scaffold manufacturing methods, materials, drug-loading methods with parameter information, and therapeutic applications with the goal of contributing to the development of new technologies or improvements to existing ones.

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Section: Fabrication Methodsmentioning

confidence: 99%

Section: Fabrication Methodsmentioning

confidence: 99%

Section: Medical Textiles Filtration and Protective Clothingmentioning

confidence: 99%

Section: Medical Textiles Filtration and Protective Clothingmentioning

confidence: 99%

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Therapeutic Agent-Loaded Fibrous Scaffolds for Biomedical Applications

et al. 2023

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“…Sustained drug delivery system ensures a steady and effective plasma concentration in the body throughout the treatment, thereby minimizing the phenomenon of peaks and valleys in the bloodstream (Reise et al, 2023). This strategy increases the safety and effectiveness of drug administration, while the occurrence of adverse drug reactions is reduced.…”

Section: Application Of Multi‐chamber Core–shell Nanofibers For Drug ...mentioning

confidence: 99%

Electrospun multi‐chamber core–shell nanofibers and their controlled release behaviors: A review

Liu,

Chen,

Lin

et al. 2024

WIREs Nanomed Nanobiotechnol

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Core–shell structure is a concentric circle structure found in nature. The rapid development of electrospinning technology provides more approaches for the production of core–shell nanofibers. The nanoscale effects and expansive specific surface area of core–shell nanofibers can facilitate the dissolution of drugs. By employing ingenious structural designs and judicious polymer selection, specialized nanofiber drug delivery systems can be prepared to achieve controlled drug release. The synergistic combination of core–shell structure and materials exhibits a strong strategy for enhancing the drug utilization efficiency and customizing the release profile of drugs. Consequently, multi‐chamber core–shell nanofibers hold great promise for highly efficient disease treatment. However, little attention concentration is focused on the effect of multi‐chamber core–shell nanofibers on controlled release of drugs. In this review, we introduced different fabrication techniques for multi‐chamber core–shell nanostructures, including advanced electrospinning technologies and surface functionalization. Subsequently, we reviewed the different controlled drug release behaviors of multi‐chamber core–shell nanofibers and their potential needs for disease treatment. The comprehensive elucidation of controlled release behaviors based on electrospun multi‐chamber core–shell nanostructures could inspire the exploration of novel controlled delivery systems. Furthermore, once these fibers with customizable drug release profiles move toward industrial mass production, they will potentially promote the development of pharmacy and the treatment of various diseases.This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies

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