Coaxial electrospun zein nanofibrous membrane for sustained release

Abstract

Zein nanofibrous membranes for sustained release have been prepared by coaxial electrospinning. Core-sheath structure has been successfully fabricated using zein as both the core and sheath component. Impact of solvent and solution concentration on the morphology of the resulting fibers was investigated. Allyltriphenylphosphonium bromide was used as a model drug to test the sustained release effect. The sustained release profile and the antimicrobial activity of the resulting membranes were investigated and compared with that of the single fluid electrospinning of zein/drug blended membrane. The ratio of the inner and outer feeding rates was found to influence the encapsulation of drugs, and in turn affect the sustained release effect of the resulting membranes. The coaxial electrospinning membrane can remarkably suppress the initial burst release of drugs by giving a releasing amount of 15% in the first 1 h when the inner/outer ratio was larger than 1:2. This drug-loaded zein membrane with preferable sustained release effect can be applied in many fields such as wound healing and packaging sector.

Electrospinning Proteins for Wound Healing Purposes: Opportunities and Challenges

“…There are various studies, which focus on electrospinning zein to produce antimicrobial wound dressings (Table 1). Zein has been electrospun alone [45,[50][51][52][53], together with synthetic polymers such as polycaprolactone (PCL) [47,48], PEO [54], PU [27] and PLA [55] as well as with natural polymers and substances including gum arabic [47,48], hyaluronic acid [46], cinnamaldehyde [26] and gum traganth [55]. Antimicrobial agents that have been incorporated into zein-based fibers include a wide range of antibiotics [26,45,46,49,51,54,55], antibacterial nanoparticles [27,50,52] as well as antimicrobial plant extracts [46,73].…”

Highly Elastic and Water Stable Zein Microfibers as a Potential Drug Delivery System for Wound Healing

“…This problem can be overcome by the use of co-axial electrospinning with aqueous ethanol as the shell solution [17,23]. Usually, zein fibers adopt the shape of flat ribbons instead of a classic tubular shape [15,18,21,[24][25][26]. This is the result of the fast evaporation of ethanol from the surface, leading to the formation of a skin around the fibers, which collapses when the solvent within the fibers evaporates completely [15,27].…”

Kinetics and Antioxidant Capacity of Proanthocyanidins Encapsulated in Zein Electrospun Fibers by Cyclic Voltammetry

“…Owing to its good oxygen barrier and high thermal resistance, , zein films and zein micro-/nanoparticles can be used for encapsulation of aromas and flavors, essential oils, controlled release of active additives, and as an active food packaging material. , Furthermore, the zein has good fiber-forming ability. It is convenient to fabricate electrospun fibers from the solution containing zein. ,,,, Herein, our attention was focused on the change of the secondary structure of zein by the addition of PA in electrospinning solutions and its influence on the shape of electrospun fibers by circular dichroism (CD).…”

“…It is convenient to fabricate electrospun fibers from the solution containing zein. 14,21,22,32,33 Herein, our attention was focused on the change of the secondary structure of zein by the addition of PA in electrospinning solutions and its influence on the shape of electrospun fibers by circular dichroism (CD).…”