Cobalt-Alloy Metal Debris in Periarticular Tissues From Total Hip Revision Arthroplasties

Betts, F.; Wright, Timothy W.; Salvati, Eduardo A.; Boskey, Adele L.; Bansal, Manjula

doi:10.1097/00003086-199203000-00011

Cited by 72 publications

(28 citation statements)

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“…The serum levels of chromium and cobalt for the 28-mm Metasul bearing were similar to those found in previously reported investigations for the modern, second-generation metal-on-metal bearings. Investigations that have been conducted to date have uniformly shown substantial elevations in serum, blood, erythrocyte and/or urine serum levels relative to preoperative values, and/or relative to levels measured after implant of metal-onpolyethylene or ceramic-on-polyethylene bearings (Betts et al 1992, Basle et al 1996, Schaffer et al 1999, Prohaska et al 2000, Harding et al 2002, Maezawa et al 2002, Savarino et al 2002, Adami et al 2003, Clarke et al 2003, Lhotka et al 2003, MacDonald et al 2003.…”

Section: Discussionmentioning

confidence: 99%

“…In addition to the corrosion potential of the implant itself, wear debris elevates the ion release due to the increased exposure of metal surface. In a number of studies, the release of metal ions from total hip arthroplasties (both locally and systemically) has been documented (Betts et al 1992, Basle et al 1996, Schaffer et al 1999, Prohaska et al 2000, Harding et al 2002, Maezawa et al 2002, Savarino et al 2002, Adami et al 2003, Clarke et al 2003, Lhotka et al 2003, MacDonald et al 2003.…”

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Exposure to chromium, cobalt and molybdenum from metal-on-metal total hip replacement and hip resurfacing arthroplasty

et al. 2006

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(2006) Exposure to chromium, cobalt and molybdenum from metal-onmetal total hip replacement and hip resurfacing arthroplasty, Acta Orthopaedica, 77:5, Background All metal implants-and metal-on-metal bearings in particular-corrode and cause a release of metal ions. Because cobalt and chromium have been shown to be carcinogenic and mutagenic in human and animal models, systemic toxicity and cancer risk are considered to be possible disadvantages of the metal-onmetal articulation.This study was designed to investigate the serum concentration profiles of chromium, cobalt and molybdenum after implantation of a Birmingham hip resurfacing arthroplasty (BHR) and a cementless total hip replacement with a 28-mm Metasul articulation (MTHR), over the first 2 years after implantation.Methods We analyzed profiles of metal ion serum levels in 111 patients implanted with a BHR, in 74 patients implanted with an MTHR, and in 130 implantfree probands control subjects using atomic absorption spectrophotometry.Results Chromium and cobalt concentrations (in µg/L) of all BHR and MTHR patients differed significantly from those of control subjects (chromium: < 0.25; cobalt: 0.25). The median chromium and cobalt concentrations in BHR patients had increased to 5.1 and 4.3 µg/ L 2 years after surgery. Concentrations in BHR patient exceeded those in the unilateral MTHR patients. Molybdenum serum concentrations hardly changed over time in either group and were not significantly different from the concentrations seen in the control subjects.Interpretation During the first 2 years after surgery, the Birmingham hip resurfacing arthroplasty leads to

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Exposure to chromium, cobalt and molybdenum from metal-on-metal total hip replacement and hip resurfacing arthroplasty

et al. 2006

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“…McKellop et al (1990McKellop et al ( , 1995 appear with Betts et al (1992), who found no correlation between implantation time and metal debris in the implant surrounding tissue. McKellop et al (1990McKellop et al ( , 1995 suggest that the surface damage occurred primarily after significant loosening of the prosthesis.…”

Section: Discussionmentioning

confidence: 94%

Surface structure of retrieved ICLH femoral cups

Wennerberg

Røkkum

Reigstad

et al. 1998

Acta Orthopaedica Scandinavica

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“…Isolated instances have been reported in which such components, including chromium derived from the articulating surface of the hip prosthesis, migrated into adjacent or distant structures. [1][2][3][4] To our knowledge, fine needle aspiration has not been previously used to detect the presence of metals in a pelvic mass appearing after hip arthroplasty.…”

Section: Background: Prosthetic Joint Replacement Is Frequently Used mentioning

confidence: 99%

Chromium-Induced Lymph Node Histiocytic Proliferation After Hip Replacement

et al. 2003

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Cobalt-Alloy Metal Debris in Periarticular Tissues From Total Hip Revision Arthroplasties

Cited by 72 publications

References 0 publications

Exposure to chromium, cobalt and molybdenum from metal-on-metal total hip replacement and hip resurfacing arthroplasty

Exposure to chromium, cobalt and molybdenum from metal-on-metal total hip replacement and hip resurfacing arthroplasty

Surface structure of retrieved ICLH femoral cups

Chromium-Induced Lymph Node Histiocytic Proliferation After Hip Replacement

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