Cobalt-catalyzed benzyl–alkynyl coupling

Abstract

Benzylic halides coupled with 1-alkynyl Grignard reagents in the presence of Co-catalyst.Leave this area blank for abstract info.R' THF room temp.

A Versatile Synthesis of Annulated Carbazole Analogs Involving a Domino Reaction of Bromomethylindoles with Arenes/Heteroarenes

“…[8] Recently, several benzo-and naphthocarbazole analogs have been explored as potential anticancer agents. Co(acac) 3 , [11] and Cu I [12] are reported. Lewis acid mediated arylation/heteroarylation of benzylic systems is usually explored with the use of arenes and heteroarenes.…”

A one pot synthesis of annulated carbazole analogs

“…[5][6][7] Very recently, several benzo and naphthocarbazole analogs have been explored as potential anticancer agents. 8 Even though, a variety of arylation protocols are known for benzylic bromides, [9][10][11][12] they are yet to be adopted for the arylation of N-protected bromomethylindoles. 13 In continuation of our interest on synthetic elaboration of N-protected bromomethylindoles, 14 we wanted to prepare N-protected-2-benzylindole 2 from the bromo compound 1.…”

Cross‐Coupling Reactions to sp Carbon Atoms

“…Benzylic halides have also been shown to couple with the alkynyl Grignard compounds (Table 9.22) [344]. Aside from halides as coupling partners, a unique cross-coupling of alkynylmagnesium reagents and vinylcarbamates to afford the corresponding enynes has been discovered to take place under Ni catalysis [346].…”