Cobalt catalyzed chemoselective reduction of nitroarenes: hydrosilylation under thermal and photochemical reaction conditions

Abstract

Commercially available Co2(CO)8 was used as an effective catalyst for the hydrosilylation of nitroarenes under both thermal and photochemical conditions. A wide variety of nitroarenes with various functionalities were selectively...

Cobalt-Catalyzed Chemodivergent Synthesis of Cyclic Amines and Lactams from Ketoacids and Anilines Using Hydrosilylation

“…18 Recently, we reported Co 2 (CO) reduction of nitroarenes using phenylsilane under thermal and photochemical conditions. 19 So, inspired by the reports on Cocatalyzed LA valorization and the high efficiency of Co 2 (CO) 8 as a catalyst in hydrosilylation, we set out to explore the synthesis of pyrrolidines and pyrrolidones from LA and primary amine with silane as the reductant and Co 2 (CO) 8 as the catalyst. Toluidine (S 1 ) and LA (A 1 ) were taken as model substrates, and the results are summarized in Table 1.…”

“…Co 2 (CO) 8 has emerged as an efficient catalyst for the hydrosilylation of acrylates, nitriles, amides, alkenes, alkynes, and esters . Recently, we reported Co 2 (CO) 8 -catalyzed reduction of nitroarenes using phenylsilane under thermal and photochemical conditions . So, inspired by the reports on Co-catalyzed LA valorization and the high efficiency of Co 2 (CO) 8 as a catalyst in hydrosilylation, we set out to explore the synthesis of pyrrolidines and pyrrolidones from LA and primary amine with silane as the reductant and Co 2 (CO) 8 as the catalyst.…”

Synergy of redox-activity and hemilability in thioamidato cobalt(iii) complexes for the chemoselective reduction of nitroarenes to anilines: catalytic and mechanistic investigation

“…26,27 Finally, another method that is also attracting increasing attention is catalytic hydrosilylation, due to the mild reaction conditions employed and the selectivity exhibited occasionally towards other functional groups. The most commonly used 3d-metal molecular catalysts in these reactions involve Fe, 28–32 Co, 33 Ni, 34,35 and more recently, Mn complexes. 36…”