Cobalt catalyzed electrochemical [4 + 2] annulation for the synthesis of sultams

Abstract

Cobalt catalyzed electrochemical [4 + 2] annulation of sulfonamides with alkynes is demonstrated in this work, which provided a practical and environmentally friendly way to synthesize structurally diverse sultams.

Renewable resources for sustainable metallaelectro-catalysed C–H activation

“…99,100 Very recently the same group have developed a [4 + 2] annulation method for the synthesis of sultams 24 using the undivided cell setup (Scheme 5A(f)). 101 Despite of extensive reports on cobaltaelectro-catalysed transformations, until recently, there was only very little understanding on the exact working mode of these novel transformations. Moreover, these reactions are mechanistically intriguing as they can be performed under exceedingly mild conditions, in stark contrast to reactions performed with chemical oxidants.…”

Acid‐Promoted Expeditious Syntheses of Aminated Dibenzosultams via Palladium/Norbornene Cooperatively Catalysed C−H Amination/Arylation

“…Compounds with the privileged scaffold usually demonstrate versatile inhibitory properties [23] . Divergent synthetic methods for assemble of sultams have been established by the group of Zhu, [24b] Wu, [25b] Ma, [25c] Kanai, [26b] and Lei, [26c] including transition‐metal or lewis acid‐catalyzed processes, [24] metal‐free oxidative annulation strategy, [25] and intermolecular cyclization [26] . Inspired by these reports and in continuation of our research interests [11d,e] in Pd/NBE‐catalyzed reaction, we are intrigued whether it would be possible to synthesize benzosultams motif through Catellani‐type reaction using aryl halide with sulfoamide group as linking group, which has not been reported to date.…”

Evolution of Earth‐Abundant 3 d‐Metallaelectro‐Catalyzed C−H Activation: From Chelation‐Assistance to C−H Functionalization without Directing Groups

“…Later, the redox mediator‐free transformation was also achieved in a green reaction medium using biomass‐derived glycerol and water as solvent [30] . Cobaltaelectro‐catalyzed alkyne annulation was later likewise achieved as well, applying the 8‐aminoquinoline amide [32] or sulfonamide [33] as complementary chelating groups by the Lei group.…”