Cobalt exposure and dyslipidemia in elderly population: the mediating role of systemic inflammation and lipid peroxidation

Huang, Jia-Hui; Li, Tao; Wu, Yi; Wang, He; Wang, Junxian; Chen, Xi; Fu, Lin

doi:10.1007/s11356-023-25910-z

Cited by 9 publications

(3 citation statements)

References 37 publications

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“…Cobalt contained in certain pigments may cause mild long‐term inflammation. Cobalt exposure has also been found to increase systemic inflammation in the older adults [48,49] . Mitochondria are responsible for producing chemical energy that sustains life and health.…”

Section: Snhl and Inflammationmentioning

confidence: 99%

“…Cobalt exposure has also been found to increase systemic inflammation in the older adults. [48,49] Mitochondria are responsible for producing chemical energy that sustains life and health. When mitochondria become dysfunctional, they excrete oxidized and fragmented mitochondrial DNA (mtDNA) into the cytoplasm, which then enters the bloodstream and causes inflammation.…”

Section: Heavy Metal-induced Hearing Lossmentioning

confidence: 99%

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Understanding the role of inflammation in sensorineural hearing loss: Current goals and future prospects

Li,

Chen,

Lin

et al. 2023

Brain-X

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Sensorineural hearing loss (SNHL) is a common otologic condition caused by damage to hair cells and spiral ganglion neurons that affects transmission pathways. Most of these cells cannot be regenerated, and there has been no breakthrough in regeneration techniques for inner ear cells. SNHL has a high incidence rate and can cause a variety of clinical symptoms, greatly impacting people's daily lives. With limited clinical treatments, the search for critical targets is urgent. Studies have shown that inflammation is prevalent in the pathogenesis of SNHL and plays a significant role in it. Inflammation is a normal body defense response, and a systemic anti‐inflammatory approach is undesirable. It is crucial for us to identify potential targets of inflammation in SNHL and take measures specifically targeting those targets with minimal systemic impact. This paper firstly describes the role of inflammation in various types of SNHL and then provides an overview of the interactions between inflammation and cochlear immunity, cochlear microcirculation, vascular spasm, and glutamate metabolism and finally comprehensively examines the feasibility of targets in these interactions. This paper is expected to facilitate the development of targeted anti‐inflammation for SNHL and provide strategies and approaches for treating clinical SNHL.

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Section: Snhl and Inflammationmentioning

confidence: 99%

Section: Heavy Metal-induced Hearing Lossmentioning

confidence: 99%

Understanding the role of inflammation in sensorineural hearing loss: Current goals and future prospects

Li,

Chen,

Lin

et al. 2023

Brain-X

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“…Environmental metallic elements, including cobalt, play a role in lipids and glucose homeostasis. New evidence has shown that environmental cobalt exposure is associated with an increase risk of dyslipidemia ( 18 ), as well as impaired fasting blood glucose ( 19 ). However, some studies have proposed the opposite viewpoint, indicating that cobalt has a beneficial effect on blood lipids and glucose.…”

Section: Introductionmentioning

confidence: 99%

Maternal cobalt concentration and risk of spontaneous preterm birth: the role of fasting blood glucose and lipid profiles

Huang,

Zheng,

Wang

et al. 2024

Front. Nutr.

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IntroductionSpontaneous preterm birth (SPB) is a significant cause of neonatal mortality, yet its etiology remains unclear. Cobalt, an essential trace element, might be a risk factor for SPB. This study aims to investigate the relationship between maternal serum cobalt concentration and SPB, and to clarify the role of blood lipids and fasting blood glucose (FBG) in this relationship.MethodsWe conducted a nested case-control study within the Beijing Birth Cohort Study. Serum samples were obtained from 222 pregnant women with SPB and 224 controls during the first (7–13 weeks of pregnancy) and third trimesters (32–42 weeks of pregnancy). Serum cobalt concentration was determined using inductively coupled plasma mass spectrometry (ICP-MS). Fasting blood glucose and lipids levels were detected using a fully automated biochemical immunoassay instrument. Logistic regression models and linear regression models were established to explore the association between serum cobalt concentration and the risk of SPB in pregnant women, and to test the mediating effect of fasting blood glucose (FBG) and lipids.ResultsWe found that the serum cobalt concentration in mothers with SPB and controls was similar in the first trimester, with values of 0.79 (0.58–1.10) ng/mL and 0.75 (0.51–1.07) ng/mL, respectively. However, in the third trimester, the cobalt concentration increased to 0.88 (0.59–1.14) ng/mL and 0.84 (0.52–1.19) ng/mL, respectively. In the logistic regression model, when considering the third trimester of pregnancy, after adjusting for ethnicity, pre-pregnancy body mass index (BMI), maternal age, education, income, and parity, it was observed that the medium level of cobalt concentration (0.63–1.07 ng/ml) had a negative correlation with the risk of SPB. The odds ratio (OR) was 0.56, with a 95% confidence interval of 0.34–0.90 ng/mL and a p-value of 0.02. This suggests that cobalt in this concentration range played a protective role against SPB. Additionally, it was found that FBG in the third trimester of pregnancy had a partial intermediary role, accounting for 9.12% of the association. However, no relationship between cobalt and SPB risk was found in the first trimester.ConclusionDuring the third trimester, intermediate levels of maternal cobalt appear to offer protection against SPB, with FBG playing a partial mediating role. To further clarify the optimal cobalt concentrations during pregnancy for different populations, a multi-center study with a larger sample size is necessary. Additionally, exploring the specific mechanism of FBG’s mediating role could provide valuable insights for improving the prevention of SPB.

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Association of Exposure to Heavy Metal Mixtures with Systemic Immune-Inflammation Index Among US Adults in NHANES 2011–2016

Sun,

Deng,

Fang

et al. 2023

Biol Trace Elem Res

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Cobalt exposure and dyslipidemia in elderly population: the mediating role of systemic inflammation and lipid peroxidation

Cited by 9 publications

References 37 publications

Understanding the role of inflammation in sensorineural hearing loss: Current goals and future prospects

Understanding the role of inflammation in sensorineural hearing loss: Current goals and future prospects

Maternal cobalt concentration and risk of spontaneous preterm birth: the role of fasting blood glucose and lipid profiles

Association of Exposure to Heavy Metal Mixtures with Systemic Immune-Inflammation Index Among US Adults in NHANES 2011–2016

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