Cobalt(II), Nickel(II) and Copper(II) complexes of a tetradentate Schiff base as photosensitizers: Quantum yield of 1O2 generation and its promising role in anti-tumor activity

Pradeepa, S.M.; Naik, H.S. Bhojya; Kumar, B. Vinay; Priyadarsini, K. Indira; Barik, Atanu; Naik, T. R. Ravikumar

doi:10.1016/j.saa.2012.09.062

Cited by 40 publications

(12 citation statements)

References 57 publications

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“…Calf thymus (CT) DNA binding experiments were performed in Tris-HCl/NaCl buffer (5 mM Tris-HCl, 5 mM NaCl) of pH 7.2 and phosphate buffer of pH 6.8 using DMF solution of the in the absence of the metal complex [47,39]. The data were presented as (η/η 0 ) 1/3 vs.…”

Section: Dna Binding Experimentsmentioning

confidence: 99%

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Synthesis and characterization of cobalt(II), nickel(II) and copper(II)-based potential photosensitizers: Evaluation of their DNA binding profile, cleavage and photocytotoxicity

Pradeepa

Naik

Kumar³

et al. 2015

Inorganica Chimica Acta

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Section: Dna Binding Experimentsmentioning

confidence: 99%

“…Enlightened by the above-mentioned facts and as a continuation of our ongoing program in the field of design and synthesis of transition-metal based cancer chemotherapeutic agents with new Schiff base ligands and photocytotoxic activities [39,40] …”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of cobalt(II), nickel(II) and copper(II)-based potential photosensitizers: Evaluation of their DNA binding profile, cleavage and photocytotoxicity

Pradeepa

Naik

Kumar³

et al. 2015

Inorganica Chimica Acta

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“…The activities of all the tested chelates may be explained on the basis of chelation theory; chelation reduces the polarity of the metal atom mainly because of partial sharing of its positive charge with the donor groups and possible -electron delocalization within the whole chelate ring. Also, chelation increases the lipophilic nature of the central atom which subsequently favors its permeation through the lipid layer of the cell membrane [26][27][28][29].…”

Section: Mass Spectra Of Schiff Base and Schiff Base Chelatesmentioning

confidence: 99%

Zr(IV), La(III), and Ce(IV) Chelates with 2-[(4-[(Z)-1-(2-Hydroxyphenyl)ethylidene]aminobutyl)-ethanimidoyl]phenol: Synthesis, Spectroscopic Characterization, and Antimicrobial Studies

El-ajaily

Abdullah

Al-janga

et al. 2015

Advances in Chemistry

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La(III), Zr(IV), and Ce(IV) chelates of 2-[(4-[(Z)-1-(2-hydroxyphenyl)ethylidene]aminobutyl)-ethanimidoyl]phenol were synthesized and characterized by using several physical techniques. The Schiff base was obtained by refluxing of o-hydroxyacetophenone with 1,4-butanediamine in 2 : 1 molar ratio. The CHN elemental analysis results showed the formation of the Schiff base and the chelates has been found to be in 1 : 1 [M : L] ratio. The molar conductance measurements revealed that all the chelates are nonelectrolytes. Structural elucidations of the ligand and its chelates were based on compatible analytical and spectroscopic evidences. The infrared spectral data revealed that the Schiff base coordinates to the metal ions through active sites which are -OH and -C=N groups. According to the electronic spectral data, an octahedral geometry was proposed for the chelates. The synthesized ligand and its metal chelates were screened for their antimicrobial activity against two Gram negative (Escherichia coli, Salmonella kentucky) and two Gram positive (Lactobacillus fermentum, Streptococcus faecalis) bacterial strains, unicellular fungi (Fusarium solani), and filamentous fungi (Aspergillus niger). The activity data showed that the metal chelates have antibacterial and antifungal activity more than the parent Schiff base ligand against one or more bacterial or fungi species. The results also indicated that the metal chelates are higher sensitive antimicrobial agents as compared to the Schiff base ligand.

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“…Vitamin B 12 , which is involved in the production of red blood cells, is a cobalt(III) complex with a substituted corrin macrocycle. Cobalt(III) complexes have shown specific hypoxic radiosensitization, photosensitization and thermosensitization as well as antibacterial, antifungal and antitumor activity in vivo [15][16][17]. Several cobalt(III) complexes coordinated through the Schiff base donors have been studied as oxygen carrier and they are useful models for bioinorganic processes, and also as catalysts for water-splitting systems [18].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, physical characterization, antibacterial activity and thermodynamic studies of five coodrdinate cobalt(III) Schiff base complexes

Esmaielzadeh¹,

Zare²,

Azimian³

2016

Bull. Chem. Soc. Eth.

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ABSTRACT. Some five-coordinated cobalt(III) complexes were synthesized and characterized using elemental analysis, 1 H NMR and IR spectra. The formation constants and the thermodynamic parameters were measured spectrophotometrically for the 1:1 adduct formation of [Co(Chel)(PBu3)]ClO4.H2O where Chel = cd3OMesalen, cd4OMesalen, cd5OMesalen: methyl-2-{[1-methyl-2-(2-hydroxy-3-, 4-, 5-methoxyphenyl)methylidynenitrilo]ethyl}amino-1-cyclopentene-dithiocarboxylate, as acceptors, with some linear and cyclic amines as donors, in different solvents at constant ionic strength (I = 0.1 M NaClO4), and at various temperatures (T = 283-313 K). The results revealed that the formation constants of the Co(III) Schiff base complexes toward a given amines donor are as follow:The trend of the formation constants of the donors (amines) toward a given cobalt(III) complex is as follow: Im > 4-MeIm > BzIm and n-butylamine > sec-butylamine > tert-butylamine. Also the effect of the solvents on the formation constants of a given cobalt(III) Schiff base complex toward a given donor are as follow: CH3CN > DMF > EtOH. The ligands and their cobalt complexes have been screened for their antibacterial activities. All the free Schiff base ligands exhibit higher antibacterial activity than the cobalt(III) complexes.

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Cobalt(II), Nickel(II) and Copper(II) complexes of a tetradentate Schiff base as photosensitizers: Quantum yield of 1O2 generation and its promising role in anti-tumor activity

Cited by 40 publications

References 57 publications

Synthesis and characterization of cobalt(II), nickel(II) and copper(II)-based potential photosensitizers: Evaluation of their DNA binding profile, cleavage and photocytotoxicity

Synthesis and characterization of cobalt(II), nickel(II) and copper(II)-based potential photosensitizers: Evaluation of their DNA binding profile, cleavage and photocytotoxicity

Zr(IV), La(III), and Ce(IV) Chelates with 2-[(4-[(Z)-1-(2-Hydroxyphenyl)ethylidene]aminobutyl)-ethanimidoyl]phenol: Synthesis, Spectroscopic Characterization, and Antimicrobial Studies

Synthesis, physical characterization, antibacterial activity and thermodynamic studies of five coodrdinate cobalt(III) Schiff base complexes

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