Cobalt(II), nickel(II), copper(II) and zinc(II) complexes of thiadiazole based Schiff base ligands: Synthesis, structural characterization, DFT, antidiabetic and molecular docking studies

Deswal, Yogesh; Asija, Sonika; Dubey, Amit; Deswal, Laxmi; Kumar, Deepak; Jindal, Deepak Kumar; Devi, Jai

doi:10.1016/j.molstruc.2021.132266

Cited by 93 publications

(34 citation statements)

References 64 publications

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“…The in vitro antimicrobial activity of the synthesized Schiff base ligands ( 1–3 ) and their corresponding diorganotin(IV) complexes ( 4–15 ) was evaluated against two Gram-positive ( Staphylococcus aureus MTCC 2901 and Bacillus subtilis MTCC 441), two Gram-negative ( Escherichia coli MTCC 732 , Pseudomonas aeruginosa MTCC 424) bacterial and two fungal ( Candida albicans MTCC 227 , Aspergillus niger MTCC 9933) strains using serial dilution method [ 32 – 34 ]. The results were reported in terms of MIC (µmol/mL).…”

Section: Methodsmentioning

confidence: 99%

Development of new tridentate ligands bearing hydrazone motif and their diorganotin(IV) complexes: Synthesis, spectral, antimicrobial and molecular docking studies

et al. 2022

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Current antimicrobial drug discovery and advancement attempts are aimed to identify new complexes that can work effectively against the infections caused by microbes. The aim of present study was to synthesize new diorganotin(IV) complexes of N' -((8-hydroxy-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolin-9-yl)methylene)-2-nitrobenzohydrazide (H 2 L 1 ), N' -((8-hydroxy-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolin-9-yl)methylene)-3-methoxybenzohydrazide (H 2 L 2 ) and N' -((8-hydroxy-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolin-9-yl)methylene)-4-methylbenzohydrazide (H 2 L 3 ) Schiff base ligands with formula R 2 SnL 1−3 (where R = Me, Et, Bu and Ph). Various spectral and physico-analytical techniques such as elemental analysis, FT-IR, multinuclear ( 1 H, 13 C, 119 Sn) NMR, HRMS and XRD were utilized to structurally elucidate the prepared compounds. Based on the spectral data, it was concluded that ligands behave in a tridentate manner and coordinates to the central tin atom through ONO donor atoms. Furthermore, the synthesized compounds were examined for in vitro antimicrobial activity against four bacterial and two fungal strains. Among the examined compounds, Ph 2 SnL 1 complex (MIC = 0.0095 µmol/mL) was found to be the most active. To rationalize the preferred mode of interactions of the most active compound, a molecular docking study of compound Ph 2 SnL 1 was executed in the binding site of 3-oxoacyl-[acyl-carrier-protein] synthase 2 (FabF) of E. coli and sterol 14-alpha demethylase of C. albicans . Compound Ph 2 SnL 1 inhibits the microbes effectively and it could be an effective and new candidate for the modulation of various infections. Graphical Abstract New diorganotin(IV) complexes ( 4–15 ) were prepared from tridentate Schiff base hydrazones ( 1–3 ). The compounds were examined for in vitro antimicrobial activity. Further, molecular docking study of the most potent compound Ph 2 SnL 1 ( 7 ) was performed against the enzyme 3-oxoacyl-[acyl-carrier-protein] synthase 2 (FabF) of E. coli and sterol 14-alpha demethylase of C. albicans . Supplementary Information The online version contains supplementary material avail...

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Section: Methodsmentioning

confidence: 99%

Development of new tridentate ligands bearing hydrazone motif and their diorganotin(IV) complexes: Synthesis, spectral, antimicrobial and molecular docking studies

et al. 2022

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“…Deswal et al, (2022) [ 78 ] recently reported a study on transition metal complexes, namely cobalt (II), nickel(II), copper(II), and zinc(II), with SB ligands and their potential antidiabetic activity by in vitro experiments on α-amylase and α-glucosidase enzymes. Complexes 25 and 26 showed good activities with IC 50 values close to those of the standard acarbose (IC 50 = 1.28 ± 0.05 and 0.58 ± 0.06 μmol/mL, respectively).…”

Section: Mononuclear Sbs Complexesmentioning

confidence: 99%

Metal Complexes with Schiff Bases: Data Collection and Recent Studies on Biological Activities

Sinicropi

Ceramella

Iacopetta

et al. 2022

IJMS

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Metal complexes play a crucial role in pharmaceutical sciences owing to their wide and significant activities. Schiff bases (SBs) are multifaceted pharmacophores capable of forming chelating complexes with various metals in different oxidation states. Complexes with SBs are extensively studied for their numerous advantages, including low cost and simple synthetic strategies. They have been reported to possess a variety of biological activities, including antimicrobial, anticancer, antioxidant, antimalarial, analgesic, antiviral, antipyretic, and antidiabetic ones. This review summarizes the most recent studies on the antimicrobial and antiproliferative activities of SBs-metal complexes. Moreover, recent studies regarding mononuclear and binuclear complexes with SBs are described, including antioxidant, antidiabetic, antimalarial, antileishmanial, anti-Alzheimer, and catecholase activities.

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“…These studies concluded that transition metal complex can increase the tolerance of pancreatic 𝛽-cells against oxidative stress, which is one of the responsible agents of diabetes. [22][23][24] Some complex triazole derivatives increase in glucose tolerance and consequently decrease in blood glucose level. [25] The mechanism of action of some transition metals has been suggested that metal ion treats hyperglycemia by activating the phosphoinositide 3-kinase pathway.…”

Section: In Vitro Antidiabetic Activitymentioning

confidence: 99%

Crystal Structure, Magnetic Study, and Antidiabetic Activity of Ni(II) Complex with N,O‐Donors Ligands

Selmi

Saïd

Nasri

et al. 2022

Cryst. Res. Technol.

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Coordination chemistry of divalent ions involving multidentate ligands have received limited attention. The present work reports the synthesis of a mixed ligand complex of Ni(II) which is characterized by X-ray single-crystal diffraction, thermal, IR spectroscopy, magnetic, and in vitro antidiabetic activity. The atomic arrangement of the complex consists of two Ni(II) bridged by two ligands of organic molecules 5-(pyridin-2-yl)-1,2,4-triazol-1-ide (Ligand L1) and 2-(4-chlorobenzoyl)benzoate (Ligand L2) which throw their nitrogen and oxygen atoms. The Ni 2+ adopts a distorted octahedral geometry (NiO 2 N 2 (OH 2 ) 2 ). Infrared spectroscopy shows the existence of O─H, C─N, C═O, and absorption bands Ni─ (O,N). The thermal study proves that this compound undergoes dehydration then decomposition over a large domain of temperature. The magnetic properties of the complex demonstrate an antiferromagnetic interaction between two adjacent nickel atoms mediated by throw ligand (L1). The antidiabetic effect of this compound is supported by a biological test in vitro and is confirmed by molecular docking suggesting good inhibitory activity of the prepared complex for 𝜶-amylase.

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Cobalt(II), nickel(II), copper(II) and zinc(II) complexes of thiadiazole based Schiff base ligands: Synthesis, structural characterization, DFT, antidiabetic and molecular docking studies

Cited by 93 publications

References 64 publications

Development of new tridentate ligands bearing hydrazone motif and their diorganotin(IV) complexes: Synthesis, spectral, antimicrobial and molecular docking studies

Development of new tridentate ligands bearing hydrazone motif and their diorganotin(IV) complexes: Synthesis, spectral, antimicrobial and molecular docking studies

Metal Complexes with Schiff Bases: Data Collection and Recent Studies on Biological Activities

Crystal Structure, Magnetic Study, and Antidiabetic Activity of Ni(II) Complex with N,O‐Donors Ligands

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