Cobalt-mediated multi-functional dressings promote bacteria-infected wound healing

Shi, Qingying; Luo, Xin; Huang, Ziqi; Midgley, Adam C.; Wang, Bo; Liu, Ruihua; Zhi, Dengke; Wei, Tingting; Zhou, Xin; Qiao, Mingqiang; Zhang, Jun; Kong, Deling; Wang, Kai

doi:10.1016/j.actbio.2018.12.048

Cited by 78 publications

(55 citation statements)

References 47 publications

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“…According to the results of 21 studies with 4284 wound samples (Sisay, Worku, & Edessa, 2019), which showed the pooled prevalence of S. aureus was 36% and the isolated E. coli was 13%, similarly, on wounds caused by burns (Farhood & Chelab, 2017), S. aureus has been named as the main pathogen of the wound, which shows the importance the elimination of Gram‐positive bacteria. Inorganic antimicrobial biomaterials such as Co 2+ used in the nanofibrous scaffold, as a multifunctional wound dressing, showed debridement absorption and proper antibacterial properties for better wound healing whereas regard to the macroscopic wounds investigation, the infection is detected obviously (Q. Shi et al, 2019), but in the present study, the nanofibrous mat containing DDAC eliminated the infection in the wound area.…”

Section: Discussionmentioning

confidence: 54%

Physical and biological properties of blend‐electrospun polycaprolactone/chitosan‐based wound dressings loaded with N‐decyl‐N, N‐dimethyl‐1‐decanaminium chloride: An in vitro and in vivo study

et al. 2020

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Dual-pump electrospinning of antibacterial N-decyl-N, N-dimethyl-1-decanaminiumchloride (DDAC)-loaded polycaprolactone (PCL) nanofibers, and chitosan (CS)/polyethylene-oxide (PEO)-based wound dressings with hydrophilic and hydrophobic properties to eliminate and absorb pathogenic bacteria from wound surface besides antibacterial action and to support wound healing and accelerate its process. Physicochemical properties of the prepared nanofibrous mat as well as antibacterial, cytotoxicity, and cell compatibility were studied. The full-thickness excisional wound healing properties up to 3 weeks using hematoxylin and eosin and Masson-trichrome staining were investigated. Addition of DDAC to CS/PEO-PCL mats decreased the diameter of the nanofibers, which is a crucial property for wound healing as large surface area per volume ratio of nanofibers, in addition to proper cell adhesion, increases loading of DDAC in mats and leads to increased cell viability and eliminating Gram-positive bacteria at in vitro studies. In vivo studies showed DDAC-loaded CS/PEO-PCL mats increased epithelialization and angiogenesis and decreased the inflammation according to histological results. We demonstrated that hydrophobic PCL/DDAC mats, besides antibacterial properties of DDAC, absorbed and eliminated the hydrophobic pathological microorganisms, whereas the hydrophilic nanofibers consisted of CS/PEO, increased the cell adhesion and proliferation due to positive charge of CS. Finally, we were able to increase the wound healing quality by using multifunctional wound dressing. CS/PEO-PCL containing 8 wt % of DDAC nanofibrous mats is promising as a wound dressing for wound management due to the favorable interactions between the pathogenic bacteria and PCL/CS-based wound dressing.

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Section: Discussionmentioning

confidence: 54%

Physical and biological properties of blend‐electrospun polycaprolactone/chitosan‐based wound dressings loaded with N‐decyl‐N, N‐dimethyl‐1‐decanaminium chloride: An in vitro and in vivo study

et al. 2020

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“…Interestingly, activation of HIF‐1α in this way reduced the inflammatory profile in the murine bladder context, another example of HIF‐α stabilisation leading to reduced inflammation. The bactericidal properties of HIF‐1α stabilisation have now been moved into clinical settings, with promising results from CoCl 2 containing bandages, that not only prevented bacterial survival and growth, but also promoted wound healing both in vitro and in vivo in a mouse infection model [57]. These recent studies highlight how host HIF‐1α could be stabilised to improve bacterial infection outcomes, particularly relevant due to rising occurrence of multidrug‐resistant bacterial strains.…”

Section: Upregulating Hif In Infectionsmentioning

confidence: 99%

If it’s not one thing, HIF’s another: immunoregulation by hypoxia inducible factors in disease

2020

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Hypoxia‐inducible factors (HIFs) have emerged in recent years as critical regulators of immunity. Localised, low oxygen tension is a hallmark of inflamed and infected tissues. Subsequent myeloid cell HIF stabilisation plays key roles in the innate immune response, alongside emerging oxygen‐independent roles. Manipulation of regulatory proteins of the HIF transcription factor family can profoundly influence inflammatory profiles, innate immune cell function and pathogen clearance and, as such, has been proposed as a therapeutic strategy against inflammatory diseases. The direction and mode of HIF manipulation as a therapy are dictated by the inflammatory properties of the disease in question, with innate immune cell HIF reduction being, in general, advantageous during chronic inflammatory conditions, while upregulation of HIF is beneficial during infections. The therapeutic potential of targeting myeloid HIFs, both genetically and pharmacologically, has been recently illuminated in vitro and in vivo, with an emerging range of inhibitory and activating strategies becoming available. This review focuses on cutting edge findings that uncover the roles of myeloid cell HIF signalling on immunoregulation in the contexts of inflammation and infection and explores future directions of potential therapeutic strategies.

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“…[ 5‐7 ] Various materials are currently employed as dressings for wound treatment, including gauze, biocompatible membranes, porous foams, and hydrogels. [ 8‐11 ] Currently available dressings protect the wound from further damage and contamination, alleviate pain, absorb exudates, maintain a moist environment, and permit oxygen permeation. [ 12‐15 ] However, there are several challenges in wound management.…”

Section: Introductionmentioning

confidence: 99%

Hydrogel‐Based Multifunctional Dressing Combining Magnetothermally Responsive Drug Delivery and Stem Cell Therapy for Enhanced Wound Healing

Zhang

Tian

Chen

et al. 2020

Advanced Therapeutics

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Multifunctional dressings are attracting increased interest in the area of tissue engineering and regenerative medicine. Wound healing is a dynamic and complex process that requires multidisciplinary management. However, dressings that exhibit both anti‐infective and tissue regenerative properties are still limited. Herein, a hydrogel‐based multifunctional dressing weaved by drug‐loaded magnetothermally responsive [Fe3O4@SiO2‐interpenetrating polymer network (IPN)] microfibers and human umbilical cord mesenchymal stem cell‐laden microfibers is developed. Magnetothermally responsive microfibers, as smart constructs, can release antibiotics on‐demand to prevent infection, due to the magnetothermal heating effect of the embedded magnetic nanoparticles and the thermoresponsive property of the IPN hydrogels. Furthermore, stem cell‐laden microfibers markedly promote cell proliferation and tissue remodeling, with improved re‐epithelization, granulation tissue formation, and collagen deposition at the wound site. Hydrogel‐based microfibers have the additional ability of absorbing exudate, providing a moist environment, and retaining the therapeutic cells. Therefore, functional microfibers and textiles significantly accelerate the healing process. An advanced dressing for wound healing, incorporating controlled drug delivery and stem cell‐based therapy is developed. Furthermore, the results of the present study reveal the potential of multifunctional dressings in tissue engineering and regenerative medicine.

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Cobalt-mediated multi-functional dressings promote bacteria-infected wound healing

Cited by 78 publications

References 47 publications

Physical and biological properties of blend‐electrospun polycaprolactone/chitosan‐based wound dressings loaded with N‐decyl‐N, N‐dimethyl‐1‐decanaminium chloride: An in vitro and in vivo study

Physical and biological properties of blend‐electrospun polycaprolactone/chitosan‐based wound dressings loaded with N‐decyl‐N, N‐dimethyl‐1‐decanaminium chloride: An in vitro and in vivo study

If it’s not one thing, HIF’s another: immunoregulation by hypoxia inducible factors in disease

Hydrogel‐Based Multifunctional Dressing Combining Magnetothermally Responsive Drug Delivery and Stem Cell Therapy for Enhanced Wound Healing

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