Cobalt-promoted regioselective preparation of aryl tetrazole amines

Abstract

A highly general, efficient and simple methodology for the regioselective synthesis of aryl tetrazole amines has been explored. The present method involves consecutive desulphurization and C-N cross-coupling reaction. Cheap, readily available and air stable cobalt catalyst has been used for this methodology. In addition, the substrate scope has been demonstrated.

Ethylenediamine Functionalized Cellulose Acetate [CAEDA] Nanosized Solid Base Catalyst in the Synthesis of 2‐Amino‐4H‐Chromenes and 5‐Substituted‐1H‐Tetrazoles

“…), these possess hypertensive, antimicrobial, anti-viral, anti-allergic, cytostatic, nootropic, and other biological activities. There are many earlier methods and different catalysts have been reported to synthesize tetrazoles [90][91][92][93][94][95][96][97][98][99] but these methods have many drawbacks such as laborious separation, recycling of catalyst, longer reaction time, harsh reaction conditions, less yield etc. So we present a convenient aproach to synthesize biologically active 5-substituted-1H-tetrazoles by using variable benzaldehyde, hydroxylamine hydrochloride and sodium azide in the presence of catalyst cellulose acetate [1,2-ethylenediamine][CAEDA] in the presence of DMF at 120°C and as shown in Scheme 2.…”