Cocaine discrimination and time-course effects in male and female Wistar rats

Anderson, Karen G.; Haaren, Frans van

doi:10.1016/s0014-2999(99)00597-x

Cited by 15 publications

(10 citation statements)

References 21 publications

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“…Consistent with our results, previous studies conducted in rats trained to discriminate cocaine did not reveal sex differences (Anderson and van Haaren, 1999;Craft and Stratmann, 1996). The present data also correspond well with results from another retrospective analysis of data collected from drug discrimination studies conducted in our laboratory in which 13 (6 women, 7 men) participants were trained to discriminate 0.375 mg triazolam (Vansickel et al, 2006).…”

Section: Discussionsupporting

confidence: 93%

“…A larger percentage of female rats also met self-administration acquisition criteria than male rats (70% vs. 30%, respectively) (Lynch and Carroll, 1999). The results of other studies, by contrast, suggest that there are few, if any, differences between male and female rats (Anderson and van Haaren, 1999;Caine et al, 2004;Craft and Stratmann, 1996;Stratmann and Craft, 1997;Haney et al, 1995). Two studies, for instance, failed to find sex differences in the discriminative-stimulus effects of cocaine in rats (Anderson and van Haaren, 1999;Craft and Stratmann, 1996).…”

Section: Introductionmentioning

confidence: 89%

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Similar discriminative-stimulus effects of d-amphetamine in women and men

Vansickel

Lile

Stoops

et al. 2007

Pharmacology Biochemistry and Behavior

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The results of controlled non-human animal and human laboratory studies are mixed regarding whether women and men respond differently to stimulant drugs. In order to assess potential gender differences in the effects of d-amphetamine, we conducted a retrospective-analysis of six studies conducted in our laboratory that used identical procedures and measures. Thirteen women and fourteen men learned to discriminate 15 mg oral d-amphetamine. After acquiring the discrimination (i.e., =80% correct responding on 4 consecutive sessions), the effects of a range of doses of damphetamine (0, 2.5, 5, 10, and 15 mg) alone and in combination with other drugs, were assessed. Only data from sessions in which d-amphetamine was administered alone were included in this analysis. d-Amphetamine functioned as a discriminative-stimulus and dose-dependently increased drug-appropriate responding. Women and men did not differ in their ability to discriminate damphetamine. Women and men differed on participant-ratings of high (women < men), nausea (women > men) and sluggish (women < men), women also experienced greater increases in diastolic pressure than men. Because the results of this study may have been confounded by the training procedures, future research should use other behavioral arrangements (e.g. drug self-administration) to determine if women and men respond differently to the effects of d-amphetamine.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 89%

Similar discriminative-stimulus effects of d-amphetamine in women and men

Vansickel

Lile

Stoops

et al. 2007

Pharmacology Biochemistry and Behavior

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“…Whether or not there are sex differences in cocaine's discriminative stimulus effects has not been evaluated in rhesus monkeys. However, studies using rodents (Anderson & van Haaren, 1999; Craft & Stratmann, 1996) reported no sex differences, and studies using humans reported no effect of sex or menstrual cycle phase on subjective effects produced by cocaine in humans (Collins, Evans, Foltin, & Haney, 2007; Mendelson et al, 1999; Singha, McCance-Katz, Petrakis, Kosten, & Oliveto, 2000). One exception to this general finding is that smoked cocaine appears to produce weaker subjective effects during luteal phase than during the follicular phase or in men (Evans, Haney, & Foltin, 2002; Sofuoglu, Dudish-Poulsen, Nelson, Pentel, & Hatsukami, 1999).…”

Section: Discussionmentioning

confidence: 98%

“…Whether or not there are sex differences in cocaine's discriminative stimulus effects has not been evaluated in rhesus monkeys. However, studies using rats reported no sex differences (K. G. Anderson & van Haaren, 1999;Craft & Stratmann, 1996), and studies in humans reported no effect of sex or menstrual cycle phase on subjective effects produced by cocaine (Collins, Evans, Foltin, & Haney, 2007;Mendelson et al, 1999;Singha, McCance-Katz, Petrakis, Kosten, & Oliveto, 2000) or amphetamine (Vansickel, Lile, Stoops, & Rush, 2007). Also, no effects of sex have been reported in clinical studies that examined the discriminative stimulus of modafinil .…”

Section: Cocaine-like Discriminative Stimulus Effects Of Modafinilmentioning

confidence: 99%

Behavioral evaluation of modafinil and the abuse-related effects of cocaine in rhesus monkeys.

Newman¹,

Negus²,

Lozama³

et al. 2010

Experimental and Clinical Psychopharmacology

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Modafinil is a central nervous system stimulant used to promote wakefulness, and it is being evaluated clinically as an agonist-based medication to treat stimulant abuse. This is the first report of the effects of modafinil on the abuse-related effects of cocaine in nonhuman primates. Three studies were conducted to examine the behavioral effects of modafinil. In the first study, the discriminative stimulus effects of modafinil were evaluated in monkeys trained to discriminate either low (0.18 mg/kg, IM) or high (0.4 mg/kg, IM) doses of cocaine from saline. Modafinil dose-dependently substituted for cocaine in 6/7 monkeys. In the second study, the effects of chronically administered modafinil (32-56 mg/kg/day, IV) on food- and cocaine-maintained operant responding were examined. Modafinil was administered 3 times/hr for 23 hr/day to ensure stable drug levels. Chronic treatment with 32 mg/kg/day modafinil selectively reduced responding maintained by intermediate (0.003 mg/kg/inj) and peak (0.01 mg/kg/inj) reinforcing doses of cocaine, but responding maintained by higher doses of cocaine was unaffected. Food-maintained behavior did not change during chronic treatment with modafinil. In a third study, after extinction of cocaine self-administration, modafinil (32 and 56 mg/kg/day, IV) significantly increased saline self-administration on the first day of treatment. These findings indicate that modafinil shares discriminative stimulus effects with cocaine and selectively reduces responding maintained by reinforcing doses of cocaine. These data are generally consistent with clinical findings and provide new evidence that these preclinical models may be useful for predicting the effectiveness of novel medications for drug abuse treatment.

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“…Results from the nonhuman animal literature suggest that the difference in drug effects seen between male and female animals may be pharmacologically specific. Male and female rats do not differ in their ability to discriminate cocaine (36) nor do sex differences emerge when timecourse effects are examined (37). However, sex differences have been found in the ability for male and female rats to discriminate morphine (38).…”

Section: Discussionmentioning

confidence: 99%

Discriminative-Stimulus Effects of Triazolam in Women and Men

Vansickel

Hays

Rush

2006

The American Journal of Drug and Alcohol Abuse

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Benzodiazepines are among the most commonly prescribed therapeutics. Women seem to be more likely than men to be prescribed a benzodiazepine and to use benzodiazepines for nonmedical reasons; they also appear to be at higher risk for benzodiazepine dependence. The aim of the present investigation was to assess the acute behavioral effects of a benzodiazepine in women and men. To accomplish this, 13 volunteers (6 women, 7 men) first learned to discriminate 0.375-mg triazolam, a triazolobenzodiazepine hypnotic. After acquiring the discrimination, (i.e., >80% correct responding on 4 consecutive sessions) a range of doses of triazolam (0, 0.0625, 0.125, 0.25, and 0.375 mg) were tested in each participant. Triazolam dose dependently increased drug-appropriate responding and subject ratings of sedation and impaired performance (i.e., significant effect of dose). The women and men did not differ significantly on any measure. The results of the present experiment suggest that women and men are not differentially sensitive to the behavioral effects of triazolam.

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Cocaine discrimination and time-course effects in male and female Wistar rats

Cited by 15 publications

References 21 publications

Similar discriminative-stimulus effects of d-amphetamine in women and men

Similar discriminative-stimulus effects of d-amphetamine in women and men

Behavioral evaluation of modafinil and the abuse-related effects of cocaine in rhesus monkeys.

Discriminative-Stimulus Effects of Triazolam in Women and Men

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