Cocaine-induced conditioned taste aversions in rats

Conditioning tastant and the acquisition of conditioned taste avoidance to drugs of abuse in DBA/2J mice

“…Reductions in saccharin intakes have been reported using each of these drugs (e.g. Cappell et al 1973;Goudie et al 1978;D'Mello et al 1979;Riley et al 1978). These results would be consistent with the development of CTA, in keeping with a more traditional interpretation of this response based on negative hedonic consequences (Riley and Tuck 1985).…”

Cocaine reverses the naltrexone-induced reduction in operant ethanol self-administration: The effects on immediate-early gene expression in the rat prefrontal cortex

“…1b). We followed this extended schedule because we wanted to avoid (a) cocaine-induced placeconditioned motor sensitisation and motor hyperactivity in the ethanol operant chambers (Antoniou et al, 1998;Stromberg and Mackler, 2005), (b) a putative cocaine-induced aversion to ethanol (this effect has been repeatedly demonstrated with saccharin by several authors, e.g., Davis and Riley, 2007;Ferrari et al, 1991;Goudie et al, 1978), (c) the formation of cocaethylene, a psychoactive compound that results from the coadministration of cocaine and ethanol (Hedaya and Pan, 1997;Laizure et al, 2003;Landry, 1992;Schechter, 1995), and (d) other non-controllable variables resulting from the concomitant exposure to cocaine and ethanol. For example, cocaine (1e30 mg/kg) administrated 15 min prior to the test session suppresses leverpressing for food (Ross and Schaal, 2002), and a similar reduction Fig.…”

Conditioned taste aversion, drugs of abuse and palatability

“…Beginning in the late 1960s, it was discovered that drugs of abuse could suppress intake of an associated taste CS, the traditional behavioral hallmark of CTAs (e.g., Berger, 1972; Cappell & LeBlanc, 1971; Cappell, LeBlanc, & Endrenyi, 1973; Carey, 1973; Davison & House, 1975; Goudie, Dickins & Thornton, 1978; Kay, 1975; Le Magnen, 1969; Nachman, Lester, & Le Magnen, 1970; Nathan & Vogel, 1975; Riley, Jacobs, & LoLordo, 1978; Vogel & Nathan, 1975; for reviews see Davis & Riley, 2010; Hunt & Amit, 1987; Riley, 2011). Complicating the straightforward interpretation that drugs of abuse induce CTAs is the simple fact that the same drugs are self-administered by humans and other animals and support conditioned place preference learning (see Bardo & Bevins, 2000; Carr, Fibiger, & Phillips; 1989; Jaffe, 1970; Schechter & Calcagnetti, 1993; Schuster & Thompson, 1969; Tzschentke, 1998, 2007; van Rees, 1979; Weeks, 1962).…”