Cocaine Preexposure Fails to Sensitize the Acquisition of Cocaine-Induced Taste Aversions

Riley, Anthony L.; Simpson, Gregory R

doi:10.1016/s0091-3057(98)00265-2

Cited by 20 publications

(20 citation statements)

References 82 publications

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“…It is important to note in this context that the US preexposure effects observed with other psychoactive drugs are comparable to those observed here and generally do not result in a complete abolition of aversions (Berman and Cannon 1974;Cappell and Le Blanc 1975;Riley and Diamond 1998;Riley and Simpson 1999;Simpson and Riley 2005;Davis and Riley 2007). In contrast, the US preexposure effects observed with classical emetics (e.g., LiCl, apomorphine) are generally quite robust, often resulting in the complete loss of taste aversion induction by the drug (Brookshire and Brackbill 1976;Cain and Baenninger 1977;Cannon et al 1977).…”

Section: Discussionsupporting

confidence: 79%

Rats preexposed to MDMA display attenuated responses to its aversive effects in the absence of persistent monoamine depletions

et al. 2011

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Section: Discussionsupporting

confidence: 79%

Rats preexposed to MDMA display attenuated responses to its aversive effects in the absence of persistent monoamine depletions

et al. 2011

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“…Clearly, in order to yoke each subject to their own pattern of infusions, the subjects had to self-administer each of the infusion doses of cocaine, prior to receiving them noncontingently. Such an order effect could potentially have reduced any aversive effects produced by noncontingent cocaine administration, in a manner reminiscent of the cocaine pre-exposure effect in taste-aversion learning (Riley and Simpson, 1999). Though unlikely, this potential explanation for the absence of differences observed between the types of cocaine delivery cannot be ruled out from the present study, and the important role that drug history can have on ongoing behavior should be acknowledged (McKearney and Barrett, 1975;Barrett and Stanley, 1983;Nader and Reboussin, 1994).…”

Section: Discussionmentioning

confidence: 81%

Contingent and noncontingent cocaine administration in rhesus monkeys: a comparison of the effects on the acquisition and performance of response sequences

Winsauer¹,

Moerschbaecher²,

Molina³

et al. 2003

Behavioural Pharmacology

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Previous studies have suggested that the effects of contingent (response dependent) and noncontingent (response independent) cocaine administration may differ, which could limit the generality and validity of laboratory studies that use only noncontingent administration. Therefore, two separate three-component multiple schedules of operant responding were used to examine the effects of both types of cocaine administration on the acquisition and performance of response sequences, in four rhesus monkeys. In one multiple schedule, responding under a fixed-ratio (FR) 60 schedule was followed by intravenous (i.v.) saline or cocaine (0.0032-0.32 mg/kg per infusion), whereas responding in the other two components (i.e. acquisition and performance) was followed by food presentation. In the second multiple schedule, the cocaine administration component consisted of a variable-time (VT) schedule that mimicked each subject's pattern of self-administration. When compared to saline administration, increasing infusion doses of cocaine decreased overall response rates comparably in both food-maintained components, irrespective of the cocaine contingency. The 0.1-0.32 mg/kg infusion doses also increased the percentage of errors in 2 of 4 subjects; however, these disruptions in accuracy were not differentially associated with the type of cocaine administration and generally occurred at doses that produced large rate-decreasing effects. Taken together, these data suggest that the effects of cocaine on complex operant behavior in monkeys may not differ substantially as a function of contingent or noncontingent administration.

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“…More relevant to the issue of drug self‐administration is the fact that a variety of drugs of abuse, such as morphine, cocaine, ethanol, nicotine, and amphetamine, 48,95–102 also produce the preexposure effect when they are administered before aversion conditioning with these same compounds. In one of the initial assessments of drug preexposure in taste aversion learning, ethanol preexposure was shown to attenuate ethanol‐induced aversions 95 .…”

Section: Drug History and Taste Aversion Learningmentioning

confidence: 99%

“…Further, although exposure to a drug prior to CTA conditioning typically attenuates subsequent aversion learning, an effect consistent with a novelty hypothesis, several reports have demonstrated clear and significant decreases in consumption (after previous drug exposure) with further conditioning. For example, Riley and Simpson 102 reported that cocaine preexposure significantly attenuated a cocaine‐induced aversion (at the same dose as that used in preexposure) on the first few saccharin–cocaine pairings. As the number of these pairings increased, cocaine‐preexposed subjects conditioned with cocaine actually displayed significant decreases in consumption, indicating that these animals had indeed developed an aversion 102,203 .…”

Section: Caveatsmentioning

confidence: 99%

Conditioned taste aversion learning

Davis

Riley

2010

Annals of the New York Academy of Sciences

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Drugs of abuse are typically discussed in terms of their rewarding effects and how these effects mediate drug taking. However, these drugs produce aversive effects that could have an important role in the overall acceptability of a drug and its likelihood of being self-administered. Rewarding and aversive effects, then, could be interpreted as separate behavioral effects, with the balance of the two determining overall drug acceptability. Interestingly, the role of aversive effects on drug acceptability in the self-administration preparation has received limited attention in this context. This chapter examines the aversive effects of drugs and discusses their role in drug taking. If these aversive effects serve a protective function, manipulations that alter or decrease these effects could have implications for drug taking. Several factors have been reported to alter conditioned taste aversion (CTA) learning, a preparation used in the assessment of the aversive effects of drugs in general. Two of these factors, drug history and strain, are reviewed here. By reviewing these, we intend to demonstrate the protective nature of aversive effects in the initiation and escalation of drug taking and to provide evidence that reductions in aversive effects could produce changes in patterns of drug self-administration that could lead to an increased vulnerability to abuse drugs by altering the reward-aversion balance. The aim of this chapter is not to question the importance of rewarding effects in self-administration but rather to provide evidence that aversive effects are an important factor that needs to be considered in discussions of drug-taking behavior.

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Cocaine Preexposure Fails to Sensitize the Acquisition of Cocaine-Induced Taste Aversions

Cited by 20 publications

References 82 publications

Rats preexposed to MDMA display attenuated responses to its aversive effects in the absence of persistent monoamine depletions

Rats preexposed to MDMA display attenuated responses to its aversive effects in the absence of persistent monoamine depletions

Contingent and noncontingent cocaine administration in rhesus monkeys: a comparison of the effects on the acquisition and performance of response sequences

Conditioned taste aversion learning

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