Cocaine Use and White Matter Hyperintensities in Homeless and Unstably Housed Women

Riley, Elise D.; Chow, Felicia C; Josephson, S. Andrew; Dilworth, Samantha E.; Lynch, Kara L.; Wade, Amanda; Braun, Carl W.; Hess, Christopher P.

doi:10.1016/j.jstrokecerebrovasdis.2021.105675

Cited by 4 publications

(6 citation statements)

References 56 publications

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“…Advanced age and male sex were reported to be major risk factors for cSVD 16,[23][24][25] . In a recent study, cerebral SVD was seen in 18.9% of age group 70s as compared to 3% in age group 40s 23 .…”

Section: Discussionmentioning

confidence: 99%

“…Cerebral microbleeds (CMBs) were rated on susceptibility-weighted imaging (SWI) based on their numbers (< 5, 5-10, or > 10). Enlarged perivascular spaces (PVS) were defined as small (< 3 mm) punctate hyperintensities on FLAIR or T2-weighted images and rated from 0 to 3: 0 (absent), 1 (< 10), 2 (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25), and 3 (> 25).…”

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confidence: 99%

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Methamphetamine use increases the risk of cerebral small vessel disease in young patients with acute ischemic stroke

Zhu

Vanderschelden

Lee

et al. 2023

Sci Rep

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Methamphetamine use causes spikes in blood pressure. Chronic hypertension is a major risk factor for cerebral small vessel disease (cSVD). The aim of this study is to investigate whether methamphetamine use increases the risk of cSVD. Consecutive patients with acute ischemic stroke at our medical center were screened for methamphetamine use and evidence of cSVD on MRI of the brain. Methamphetamine use was identified by self-reported history and/or positive urine drug screen. Propensity score matching was used to select non-methamphetamine controls. Sensitivity analysis was performed to assess the effect of methamphetamine use on cSVD. Among 1369 eligible patients, 61 (4.5%) were identified to have a history of methamphetamine use and/or positive urine drug screen. Compared with the non-methamphetamine group (n = 1306), the patients with methamphetamine abuse were significantly younger (54.5 ± 9.7 vs. 70.5 ± 12.4, p < 0.001), male (78.7% vs. 54.0%, p < 0.001) and White (78.7% vs. 50.4%, p < 0.001). Sensitivity analysis showed that methamphetamine use was associated with increased white matter hyperintensities, lacunes, and total burden of cSVD. The association was independent of age, sex, concomitant cocaine use, hyperlipidemia, acute hypertension, and stroke severity. Our findings suggest that methamphetamine use increases the risk of cSVD in young patients with acute ischemic stroke.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Methamphetamine use increases the risk of cerebral small vessel disease in young patients with acute ischemic stroke

Zhu

Vanderschelden

Lee

et al. 2023

Sci Rep

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“…13 Those who used cocaine were also seven times as likely to have white matter hyperintensities compared to those who did not. 14 On average, people who use stimulants self-report more than one acute toxicity event per year (defined as taking enough of a stimulant to feel so sick or scared that one's life may be in danger). 15 Many consider symptoms of stimulant toxicity, such as chest tightness, a "normal" part of the experience, 16 implying that cardiovascular symptoms in the setting of drug use often occur over long periods of time and may be difficult to separate from stimulant-related toxicity.…”

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confidence: 99%

A Chronic Condition Disguised as an Acute Event: the Case for Re-thinking Stimulant Overdose Death

2022

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“…Advanced age and male sex were reported to be major risk factors for cSVD [16, [23][24][25]. In a recent study, cerebral SVD was seen in 18.9% of age group 70s as compared to 3% in age group 40s [23].…”

Section: Discussionmentioning

confidence: 99%

Methamphetamine use increases the risk of cerebral small vessel disease in young patients with acute ischemic stroke

Zhu

Vanderschelden

Shafie

et al. 2023

Preprint

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Methamphetamine use causes spikes in blood pressure. Chronic hypertension is a major risk factor for cerebral small vessel disease (cSVD). The aim of this study is to investigate whether methamphetamine use increases the risk of cSVD. Consecutive patients with acute ischemic stroke at our medical center were screened for methamphetamine use and evidence of cSVD on MRI of the brain. Methamphetamine use was identified by self-reported history and/or positive urine drug screen. Propensity score matching was used to select non-methamphetamine controls. Sensitivity analysis was performed to assess the effect of methamphetamine use on cSVD. Among 1369 eligible patients, 61 (4.5%) were identified to have a history of methamphetamine use and/or positive urine drug screen. Compared with the non-methamphetamine group (n = 1308), the patients with methamphetamine abuse were significantly younger (54.5 ± 6.9 vs. 70 ± 12.4, p < 0.001), male (77% vs. 54%, p < 0.001) and White (78.7% vs. 51%, p < 0.001). Sensitivity analysis showed that methamphetamine use was associated with increased white matter hyperintensities, lacunes, and total burden of cSVD. The association was independent of age, sex, acute hypertension, and stroke severity. Our findings suggest that methamphetamine use increases the risk of cSVD in young patients with acute ischemic stroke.

show abstract

Cocaine Use and White Matter Hyperintensities in Homeless and Unstably Housed Women

Cited by 4 publications

References 56 publications

Methamphetamine use increases the risk of cerebral small vessel disease in young patients with acute ischemic stroke

Methamphetamine use increases the risk of cerebral small vessel disease in young patients with acute ischemic stroke

A Chronic Condition Disguised as an Acute Event: the Case for Re-thinking Stimulant Overdose Death

Methamphetamine use increases the risk of cerebral small vessel disease in young patients with acute ischemic stroke

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