Coccidioidomycosis: Studies of Canine Vaccination and Therapy

Castleberry, M. W.; Converse, John L.; Sinski, James T.; Lowe, Edwin P.; Pakes, S. P.; Del-Favero, J.

doi:10.1093/infdis/115.1.41

Cited by 15 publications

(8 citation statements)

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“…It seems unlikely, however, that nonspecific immunity is a major factor. In previous intraperitoneal studies with live and formaldehyde-inactivated vaccines (3), the protective effects have been confirmed in subcutaneously immunized monkeys (4, 5) and dogs (1,2) challenged by the respiratory route. Moreover, the histologic changes in the immunized and control animals were similar regardless of the route of immunization and challenge (3,5 4.…”

Section: Discussionmentioning

confidence: 69%

Experimental Irradiated Arthrospore Vaccine Against Coccidioidomycosis in Mice

Pulliam¹,

Converse²,

Snyder³

et al. 1967

J Bacteriol

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An experimental irradiated (6'Co) arthrospore vaccine against coccidioidomycosis protected approximately 75% of mice from death after an intraperitoneal challenge sufficient to kill approximately 90% of the nonimmunized control mice. Although the majority of the immunized mice became infected with Coccidioides immitis, the histologic lesions were substantially less severe than those in the nonimmunized controls, particularly in the pulmonary region. Although arthrospores irradiated with 1, 2, or 3 million roentgens lost their ability to multiply in various laboratory media (probably through interference with cell division), partial conversion to the parasitic phase (spherule) was observed after animal inoculation (rounding out of arthrospores into immature spherules, but without development of endospores). Duration of viability of these structures has yet to be determined. The value of nonviable vaccines in experimental coccidioidomycosis has been extensively investigated in several laboratory animals. The guinea pig was used in studies by Negroni, Vivoli, and Bonfiglioli (16) and by Vogel et al. (23). The studies of Friedman and Smith (6) and Converse et al. (3) were made in mice. Very thorough and extensive studies in mice, comparing the parasitic and saprophytic phases of Coccidioides immitis as antigens, various routes of inoculation, various schedules of

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Section: Discussionmentioning

confidence: 69%

Experimental Irradiated Arthrospore Vaccine Against Coccidioidomycosis in Mice

Pulliam¹,

Converse²,

Snyder³

et al. 1967

J Bacteriol

Self Cite

View full text Add to dashboard Cite

show abstract

“…It seems unlikely, however, that nonspecific immunity is a major factor. In previous intraperitoneal studies with live and formaldehyde-inactivated vaccines (3), the protective effects have been confirmed in subcutaneously immunized monkeys (4,5) and dogs (1,2) challenged by the respiratory route. Moreover, the histologic changes in the immunized and control animals were similar regardless of the route of immunization and challenge (3,5).…”

Section: Methodsmentioning

confidence: 71%

“…Moreover, the histologic changes in the immunized and control animals were similar regardless of the route of immunization and challenge (3,5). formaldehyde-inactivated vaccines was maintained with both routes of immunization and challenge (1,2,3,5).…”

Section: Methodsmentioning

confidence: 99%

“…Comparison of vaccines against C. immitis shows, in general, that the killed vaccines protect againt death (3,6), whereas the live vaccine offers nearly universal protection against infection as well as death (1)(2)(3)(4)(5). These preliminary data suggest that the irradiated vaccine offers the same protection as the formaldehyde- inactivated vaccine, and in addition, shows less severe infection.…”

Section: Methodsmentioning

confidence: 99%

“…(4,5), Lowe et al. (15), and Sinski et al (22) in the rhesus monkey (Macaca mulatta), and by Castleberry et al (1) in the dog.…”

mentioning

confidence: 99%

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