Coccygeal Polypoid Eccrine Nevus

Charifa, Ahmad; Ko, Christine J.

doi:10.5858/arpa.2018-0055-rs

Cited by 16 publications

(22 citation statements)

References 17 publications

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“…Interestingly, while lipomas are phenotypically homogeneous, genetically they are very heterogenous and about two-thirds have chromosomal aberrations [29]. The most common rearrangements involve the HMGA2 gene.…”

Section: Discussionmentioning

confidence: 99%

Reduced lipolysis in lipoma phenocopies lipid accumulation in obesity

Duc

Chen²,

Popkova

et al. 2020

Int J Obes

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Background Elucidation of lipid metabolism and accumulation mechanisms is of paramount importance to understanding obesity and unveiling therapeutic targets. In vitro cell models have been extensively used for these purposes, yet, they do not entirely reflect the in vivo setup. Conventional lipomas, characterized by the presence of mature adipocytes and increased adipogenesis, could overcome the drawbacks of cell cultures. Also, they have the unique advantage of easily accessible matched controls in the form of subcutaneous adipose tissue (SAT) from the same individual. We aimed to determine whether lipomas are a good model to understand lipid accumulation. Methods We histologically compared lipomas and control SAT, followed by assessment of the lipidome using high-resolution 1H NMR spectroscopy and ESI-IT mass spectrometry. RNA-sequencing was used to obtain the transcriptome of lipomas and the matched SAT. Results We found a significant increase of small-size (maximal axis < 70 µm) and very big (maximal axis > 150 µm) adipocytes within lipomas. This suggests both enhanced adipocyte proliferation and increased lipid accumulation. We further show that there is no significant change in the lipid composition compared to matched SAT. To better delineate the pathophysiology of lipid accumulation, we considered two groups with different genetic backgrounds: (1) lipomas with HMGA2 fusions and (2) without gene fusions. To reduce the search space for genes that are relevant for lipid pathophysiology, we focused on the overlapping differentially expressed (DE) genes between the two groups. Gene Ontology analysis revealed that DE genes are enriched in pathways related to lipid accumulation. Conclusions We show that the common shared lipid accumulation mechanism in lipoma is a reduction in lipolysis, with most gene dysregulations leading to a reduced cAMP in the adipocyte. Superficial lipomas could thus be used as a model for lipid accumulation through altered lipolysis as found in obese patients.

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Section: Discussionmentioning

confidence: 99%

Reduced lipolysis in lipoma phenocopies lipid accumulation in obesity

Duc

Chen²,

Popkova

et al. 2020

Int J Obes

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“…9,10 Among the potential risk factors that may be the cause of lipomas, there are: obesity, alcohol abuse, liver disease and glucose intolerance. 1 Giant lipomas are rarely diagnosed. There are few case reports in the literature describing the presence of such changes in various areas of the human body.…”

Section: Discussionmentioning

confidence: 99%

“…These changes are often presented in the upper part of the body, especially in the head, neck, shoulders and back. 1 In rare cases, lipomas may appear in the other regions of the human body or even in internal organs such as heart or stomach. [2][3][4] Usually the resulting lesions are harmless and painless, therefore do not require treatment.…”

Section: Introductionmentioning

confidence: 99%

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Giant Lipoma in the Fronto-Temporo-Parietal Region in an Adult Man: Case Report and Literature Review

Szewc¹,

Gawlik²,

Żebrowski³

et al. 2020

CCID

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Lipoma belongs to a group of benign mesenchymal tumors. It is in the form of soft masses of adipose tissue encapsulated by a thin layer of fibrous tissue and usually localized subcutaneously. The tumor most often appears in the upper part of the body. Lipomas tend to grow slowly and are small (less than 5cm) lesions. Larger tumors are rare. In this article, we present the case of a patient with a giant head lipoma in the fronto-temporo-parietal region. Both tumor size and location are unique and no such case has been described in the literature so far.

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“…This problem is often related to the nodule or infiltrated unpainful tissue, which can cause symptoms secondary to the regional compression of joints or due to the rapid growth. (1) einstein (São Paulo). 2020;18:1-4…”

Section: ❚ Resumomentioning

confidence: 99%

Caecal appendix lipomatosis in a pregnant patient mimicking acute appendicitis

Sanches

Júnior

Falsarella

et al. 2020

Einstein (São Paulo)

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A 34-years-old pregnant woman admitted in the emergency unit complaining about worsening right iliac fossa pain for 2 days. Acute appendicitis was the suspected diagnosis. Laboratory exams were ordered and results were within normal limits for infectious and inflammatory aspects. Ultrasound scan revealed a pregnancy in course without alterations and a thickness of the appendix wall without inflammatory signs in the surrounding tissue. Because the suspicion of acute appendicitis remained, a magnetic resonance was done and confirmed the diagnosis of a cecal appendix lipomatosis.

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Coccygeal Polypoid Eccrine Nevus

Cited by 16 publications

References 17 publications

Reduced lipolysis in lipoma phenocopies lipid accumulation in obesity

Reduced lipolysis in lipoma phenocopies lipid accumulation in obesity

Giant Lipoma in the Fronto-Temporo-Parietal Region in an Adult Man: Case Report and Literature Review

Caecal appendix lipomatosis in a pregnant patient mimicking acute appendicitis

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